FZD2

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Frizzled family receptor 2
Identifiers
Symbols FZD2 ; Fz2; fz-2; fzE2; hFz2
External IDs OMIM600667 MGI1888513 HomoloGene20377 IUPHAR: FZD2 GeneCards: FZD2 Gene
RNA expression pattern
PBB GE FZD2 210220 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2535 57265
Ensembl ENSG00000180340 ENSMUSG00000050288
UniProt Q14332 Q9JIP6
RefSeq (mRNA) NM_001466 NM_020510
RefSeq (protein) NP_001457 NP_065256
Location (UCSC) Chr 17:
42.63 – 42.64 Mb
Chr 11:
102.6 – 102.61 Mb
PubMed search [1] [2]

Frizzled-2 is a protein that in humans is encoded by the FZD2 gene.[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.[3]

See also[edit]

References[edit]

  1. ^ Zhao Z, Lee CC, Baldini A, Caskey CT (Nov 1995). "A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1". Genomics 27 (2): 370–3. doi:10.1006/geno.1995.1060. PMID 7558010. 
  2. ^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (Dec 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155. 
  3. ^ a b "Entrez Gene: FZD2 frizzled homolog 2 (Drosophila)". 

External links[edit]

  • "Frizzled Receptors: FZD2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.