Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif. The FZD6 protein is believed to be the receptor for the WNT4 ligand.
In 2004, researchers at the Howard Hughes Medical Institute showed that FZD6 controls hair patterning in mice, and its human homologue is understood to play a part in the formation of hair whorls and cowlicks.
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