Somatostatin receptor 2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Somatostatin receptor 2
Identifiers
Symbol SSTR2
External IDs OMIM182452 MGI98328 HomoloGene37427 IUPHAR: sst2 ChEMBL: 1804 GeneCards: SSTR2 Gene
RNA expression pattern
PBB GE SSTR2 214597 at tn.png
PBB GE SSTR2 217455 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6752 20606
Ensembl ENSG00000180616 ENSMUSG00000047904
UniProt P30874 P30875
RefSeq (mRNA) NM_001050 NM_001042606
RefSeq (protein) NP_001041 NP_001036071
Location (UCSC) Chr 17:
71.16 – 71.17 Mb
Chr 11:
113.62 – 113.63 Mb
PubMed search [1] [2]

Somatostatin receptor type 2 is a protein that in humans is encoded by the SSTR2 gene.[1]

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.[2]

Interactions[edit]

Somatostatin receptor 2 has been shown to interact with SHANK2.[3]

Therapeutic targeting[edit]

Most pituitary adenomas express SSTR2, but other somatostatin receptors are also found.<[4] Somatostatin analogs (i.e. Octreotide, Lanreotide ) are used to stimulate this receptors, and thus to inhibit further tumor proliferation.[5]

See also[edit]

References[edit]

  1. ^ Yamada Y, Stoffel M, Espinosa R 3rd, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI (Apr 1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics 15 (2): 449–52. doi:10.1006/geno.1993.1088. PMID 8449518. 
  2. ^ "Entrez Gene: SSTR2 somatostatin receptor 2". 
  3. ^ Zitzer, H; Hönck H H; Bächner D; Richter D; Kreienkamp H J (Nov 1999). "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain". J. Biol. Chem. (UNITED STATES) 274 (46): 32997–3001. doi:10.1074/jbc.274.46.32997. ISSN 0021-9258. PMID 10551867. 
  4. ^ Miller GM, Alexander JM, Bikkal HA, Katznelson L, Zervas NT, Klibanski A (April 1995). "Somatostatin receptor subtype gene expression in pituitary adenomas". J. Clin. Endocrinol. Metab. 80 (4): 1386–92. doi:10.1210/jcem.80.4.7714115. PMID 7714115. 
  5. ^ Zatelli MC, Ambrosio MR, Bondanelli M, Uberti EC (April 2007). "Control of pituitary adenoma cell proliferation by somatostatin analogs, dopamine agonists and novel chimeric compounds". Eur. J. Endocrinol. 156 Suppl 1: S29–35. doi:10.1530/eje.1.02352. PMID 17413185. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.