Somatostatin receptor 2

Somatostatin receptor 2
Identifiers
Symbols	SSTR2;
External IDs	OMIM: 182452 MGI: 98328 HomoloGene: 37427 IUPHAR: sst2 GeneCards: SSTR2 Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity • somatostatin receptor activity • protein binding • PDZ domain binding Cellular component • membrane fraction • cytoplasm • plasma membrane • plasma membrane • integral to plasma membrane Biological process • regulation of muscle contraction • G-protein signaling, coupled to cyclic nucleotide second messenger • inhibition of adenylate cyclase activity by G-protein signaling pathway • neuropeptide signaling pathway • cell-cell signaling • spermatogenesis • response to nutrient • digestion • negative regulation of cell proliferation • cerebellum development • peristalsis • forebrain development • response to starvation • cellular response to glucocorticoid stimulus • cellular response to estradiol stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6752	20606
Ensembl	ENSG00000180616	ENSMUSG00000047904
UniProt	P30874	P30875
RefSeq (mRNA)	NM_001050.2	NM_009217
RefSeq (protein)	NP_001041.1	NP_033243
Location (UCSC)	Chr 17: 71.16 – 71.17 Mb	Chr 11: 113.48 – 113.49 Mb
PubMed search	[1]	[2]

Somatostatin receptor type 2 is a protein that in humans is encoded by the SSTR2 gene.

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.

Interactions

Somatostatin receptor 2 has been shown to interact with SHANK2.

See also

• Somatostatin receptor

Further reading

• Yamada Y, Post SR, Wang K et al (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. doi:10.1073/pnas.89.1.251. PMC 48214. PMID 1346068. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=48214. 
• Reubi JC, Waser B, Schaer JC, Markwalder R (1995). "Somatostatin receptors in human prostate and prostate cancer". J. Clin. Endocrinol. Metab. 80 (9): 2806–14. doi:10.1210/jc.80.9.2806. PMID 7673428. 
• Kagimoto S, Yamada Y, Kubota A et al (1994). "Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein". Biochem. Biophys. Res. Commun. 202 (2): 1188–95. doi:10.1006/bbrc.1994.2054. PMID 7914078. 
• Fujita T, Yamaji Y, Sato M et al (1994). "Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines". Life Sci. 55 (23): 1797–806. doi:10.1016/0024-3205(94)90090-6. PMID 7968260. 
• Patel YC, Greenwood M, Kent G et al (1993). "Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation". Biochem. Biophys. Res. Commun. 192 (1): 288–94. doi:10.1006/bbrc.1993.1412. PMID 8386508. 
• Fukusumi S, Kitada C, Takekawa S et al (1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochem. Biophys. Res. Commun. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122. 
• Jaïs P, Terris B, Ruszniewski P et al (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". Eur. J. Clin. Invest. 27 (8): 639–44. doi:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525. 
• Lopez F, Estève JP, Buscail L et al (1997). "The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling". J. Biol. Chem. 272 (39): 24448–54. doi:10.1074/jbc.272.39.24448. PMID 9305905. 
• Tsutsumi A, Takano H, Ichikawa K et al (1997). "Expression of somatostatin receptor subtype 2 mRNA in human lymphoid cells". Cell. Immunol. 181 (1): 44–9. doi:10.1006/cimm.1997.1193. PMID 9344495. 
• Sharma K, Patel YC, Srikant CB (1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest". Mol. Endocrinol. 13 (1): 82–90. doi:10.1210/me.13.1.82. PMID 9892014. 
• Kumar U, Sasi R, Suresh S et al (1999). "Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis". Diabetes 48 (1): 77–85. doi:10.2337/diabetes.48.1.77. PMID 9892225. 
• Zitzer H, Richter D, Kreienkamp HJ (1999). "Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1". J. Biol. Chem. 274 (26): 18153–6. doi:10.1074/jbc.274.26.18153. PMID 10373412. 
• Zitzer H, Hönck HH, Bächner D et al (2000). "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain". J. Biol. Chem. 274 (46): 32997–3001. doi:10.1074/jbc.274.46.32997. PMID 10551867. 
• Petersenn S, Rasch AC, Presch S et al (2000). "Genomic structure and transcriptional regulation of the human somatostatin receptor type 2". Mol. Cell. Endocrinol. 157 (1–2): 75–85. doi:10.1016/S0303-7207(99)00161-6. PMID 10619399. 
• Kreienkamp HJ, Zitzer H, Richter D (2001). "Identification of proteins interacting with the rat somatostatin receptor subtype 2". J. Physiol. Paris 94 (3–4): 193–8. doi:10.1016/S0928-4257(00)00204-7. PMID 11087996. 
• Ho MK, Yung LY, Chan JS et al (2001). "Gα14 links a variety of Gi- and Gs-coupled receptors to the stimulation of phospholipase C". Br. J. Pharmacol. 132 (7): 1431–40. doi:10.1038/sj.bjp.0703933. PMC 1572686. PMID 11264236. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1572686. 
• Zatelli MC, Tagliati F, Taylor JE et al (2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". J. Clin. Endocrinol. Metab. 86 (5): 2161–9. doi:10.1210/jc.86.5.2161. PMID 11344221. 
• Talme T, Ivanoff J, Hägglund M et al (2001). "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3". Clin. Exp. Immunol. 125 (1): 71–9. doi:10.1046/j.1365-2249.2001.01577.x. PMC 1906108. PMID 11472428. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1906108. 
• Klisovic DD, O'Dorisio MS, Katz SE et al (2001). "Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study". Invest. Ophthalmol. Vis. Sci. 42 (10): 2193–201. PMID 11527930. 

External links

• "Somatostatin Receptors: sst₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2433. 
• MeSH somatostatin+receptor+2

This article incorporates text from the United States National Library of Medicine, which is in the public domain.