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Sphingosine-1-phosphate receptor 4
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols S1PR4 ; EDG6; LPC1; S1P4; SLP4
External IDs OMIM603751 MGI1333809 HomoloGene2799 IUPHAR: 278 ChEMBL: 3230 GeneCards: S1PR4 Gene
RNA expression pattern
PBB GE EDG6 206437 at tn.png
PBB GE EDG6 215859 at tn.png
More reference expression data
Species Human Mouse
Entrez 8698 13611
Ensembl ENSG00000125910 ENSMUSG00000044199
UniProt O95977 Q9Z0L1
RefSeq (mRNA) NM_003775 NM_010102
RefSeq (protein) NP_003766 NP_034232
Location (UCSC) Chr 19:
3.17 – 3.18 Mb
Chr 10:
81.5 – 81.5 Mb
PubMed search [1] [2]

Sphingosine-1-phosphate receptor 4 also known as S1PR4 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P4.[1]


This gene is a member of the endothelial differentiation, G-protein-coupled (EDG) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.