P2RY11

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Purinergic receptor P2Y, G-protein coupled, 11
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols P2RY11 ; P2Y11
External IDs OMIM602697 HomoloGene130446 IUPHAR: P2Y11 ChEMBL: 4867 GeneCards: P2RY11 Gene
RNA expression pattern
PBB GE P2RY11 214546 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5032 235036
Ensembl ENSG00000244165 ENSMUSG00000004100
UniProt Q96G91 Q91YU8
RefSeq (mRNA) NM_002566 NM_145610.2
RefSeq (protein) NP_002557 NP_663585.2
Location (UCSC) Chr 19:
10.22 – 10.23 Mb
Chr 9:
20.69 – 20.7 Mb
PubMed search [1] [2]

P2Y purinoceptor 11 is a protein that in humans is encoded by the P2RY11 gene.[1][2]

The product of this gene, P2Y11, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occurring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.[2]

See also[edit]

References[edit]

  1. ^ Communi D, Govaerts C, Parmentier M, Boeynaems JM (Jan 1998). "Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase". J Biol Chem 272 (51): 31969–73. doi:10.1074/jbc.272.51.31969. PMID 9405388. 
  2. ^ a b "Entrez Gene: P2RY11 purinergic receptor P2Y, G-protein coupled, 11". 

External links[edit]

  • "P2Y Receptors: P2Y11". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.