TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002). See also TAS2R10 (MIM 604791).[supplied by OMIM]
^Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (Oct 2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat Genet32 (3): 397–401. doi:10.1038/ng1014. PMID12379855.
^Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ (Feb 2003). "Identification and characterization of human taste receptor genes belonging to the TAS2R family". Cytogenet Genome Res98 (1): 45–53. doi:10.1159/000068546. PMID12584440.
Zhang Y, Hoon MA, Chandrashekar J et al. (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID12581520.