GPR110

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G protein-coupled receptor 110
Identifiers
Symbols GPR110 ; KPG_012; PGR19; hGPCR36
External IDs MGI1924846 HomoloGene124643 IUPHAR: GPR110 GeneCards: GPR110 Gene
RNA expression pattern
PBB GE GPR110 220907 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 266977 77596
Ensembl ENSG00000153292 ENSMUSG00000041293
UniProt Q5T601 Q8VEC3
RefSeq (mRNA) NM_025048 NM_133776
RefSeq (protein) NP_079324 NP_598537
Location (UCSC) Chr 6:
47 – 47.04 Mb
Chr 17:
43.27 – 43.32 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 110 is a protein that in humans is encoded by the GPR110 gene.[1][2] This gene encodes a member of the adhesion-GPCR receptor family.[3] Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[4]

References[edit]

  1. ^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. 
  2. ^ "Entrez Gene: GPR110 G protein-coupled receptor 110". 
  3. ^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  4. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. 

Further reading[edit]