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G protein-coupled receptor 126
Symbols GPR126 ; APG1; DREG; PS1TP2; VIGR
External IDs OMIM612243 MGI1916151 HomoloGene10724 IUPHAR: GPR126 GeneCards: GPR126 Gene
RNA expression pattern
PBB GE GPR126 213094 at tn.png
More reference expression data
Species Human Mouse
Entrez 57211 215798
Ensembl ENSG00000112414 ENSMUSG00000039116
UniProt Q86SQ4 Q6F3F9
RefSeq (mRNA) NM_001032394 NM_001002268
RefSeq (protein) NP_001027566 NP_001002268
Location (UCSC) Chr 6:
142.62 – 142.77 Mb
Chr 10:
14.4 – 14.55 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 126 is a protein that in humans is encoded by the GPR126 gene.[1][2] This gene encodes a member of the adhesion-GPCR receptor family [3] Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[4] It is involved in the process of myelination.[5]


  1. ^ Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (Feb 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun 301 (3): 725–34. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841. 
  2. ^ "Entrez Gene: GPR126 G protein-coupled receptor 126". 
  3. ^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  4. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. 
  5. ^ Monk KR, Oshima K, Jörs S, Heller S, Talbot WS (May 2011). "Gpr126 is essential for peripheral nerve development and myelination in mammals". Development 138 (13): 2673–2680. doi:10.1242/dev.062224. PMC 3109596. PMID 21613327. Lay 

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