GPR126

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G protein-coupled receptor 126
Identifiers
Symbols GPR126 ; APG1; DREG; PS1TP2; VIGR
External IDs OMIM612243 MGI1916151 HomoloGene10724 IUPHAR: GPR126 GeneCards: GPR126 Gene
RNA expression pattern
PBB GE GPR126 213094 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 57211 215798
Ensembl ENSG00000112414 ENSMUSG00000039116
UniProt Q86SQ4 Q6F3F9
RefSeq (mRNA) NM_001032394 NM_001002268
RefSeq (protein) NP_001027566 NP_001002268
Location (UCSC) Chr 6:
142.62 – 142.77 Mb
Chr 10:
14.4 – 14.55 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 126 is a protein that in humans is encoded by the GPR126 gene.[1][2] This gene encodes a member of the adhesion-GPCR receptor family [3] Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[4] It is involved in the process of myelination.[5]

References[edit]

  1. ^ Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (Feb 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun 301 (3): 725–34. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841. 
  2. ^ "Entrez Gene: GPR126 G protein-coupled receptor 126". 
  3. ^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  4. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. 
  5. ^ Monk KR, Oshima K, Jörs S, Heller S, Talbot WS (May 2011). "Gpr126 is essential for peripheral nerve development and myelination in mammals". Development 138 (13): 2673–2680. doi:10.1242/dev.062224. PMC 3109596. PMID 21613327. Lay summarynews.wustl.edu. 

Further reading[edit]