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Wntless Wnt ligand secretion mediator
Symbols WLS ; C1orf139; EVI; GPR177; MRP; mig-14
External IDs OMIM611514 MGI1915401 HomoloGene11779 GeneCards: WLS Gene
RNA expression pattern
PBB GE GPR177 221958 s at tn.png
More reference expression data
Species Human Mouse
Entrez 79971 68151
Ensembl ENSG00000116729 ENSMUSG00000028173
UniProt Q5T9L3 Q6DID7
RefSeq (mRNA) NM_001002292 NM_026582
RefSeq (protein) NP_001002292 NP_080858
Location (UCSC) Chr 1:
68.56 – 68.7 Mb
Chr 3:
159.84 – 159.94 Mb
PubMed search [1] [2]

G protein-coupled receptor 177 (GPR177), commonly known as Wntless, is a human gene[1] that encodes a receptor for Wnt proteins in Wnt-secreting cells.[2]

Wntless was recently shown to be a cargo for the retromer complex.[2] It has been found essential for hair follicle induction.[3]


  1. ^ "Entrez Gene: GPR177 G protein-coupled receptor 177". 
  2. ^ a b Eaton S (January 2008). "Retromer retrieves wntless". Dev. Cell. 14 (1): 4–6. doi:10.1016/j.devcel.2007.12.014. PMID 18194646. 
  3. ^ Fu, J.; Hsu, W. (2012). "Epidermal Wnt Controls Hair Follicle Induction by Orchestrating Dynamic Signaling Crosstalk between the Epidermis and Dermis". Journal of Investigative Dermatology 133 (4): 890–8. doi:10.1038/jid.2012.407. PMID 23190887.  edit

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.