Platelet-activating factor receptor

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Platelet-activating factor receptor
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PTAFR ; PAFR
External IDs OMIM173393 MGI106066 HomoloGene20260 IUPHAR: PAF receptor ChEMBL: 250 GeneCards: PTAFR Gene
RNA expression pattern
PBB GE PTAFR 206278 at tn.png
PBB GE PTAFR 211661 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5724 19204
Ensembl ENSG00000169403 ENSMUSG00000056529
UniProt P25105 Q62035
RefSeq (mRNA) NM_000952 NM_001081211
RefSeq (protein) NP_000943 NP_001074680
Location (UCSC) Chr 1:
28.47 – 28.52 Mb
Chr 4:
132.56 – 132.58 Mb
PubMed search [1] [2]

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor.[1][2]

The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM][3] Its pathogenetic role in chronic kidney failure has also been reported recently. [4]

Ligands

Agonists

Antagonists

References[edit]

  1. ^ Seyfried CE, Schweickart VL, Godiska R, Gray PW (1992). "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1". Genomics 13 (3): 832–4. doi:10.1016/0888-7543(92)90162-L. PMID 1322356. 
  2. ^ Ishii S, Nagase T, Shimizu T (2002). "Platelet-activating factor receptor". Prostaglandins Other Lipid Mediat. 68-69: 599–609. doi:10.1016/S0090-6980(02)00058-8. PMID 12432946. 
  3. ^ "Entrez Gene: PTAFR platelet-activating factor receptor". 
  4. ^ Correa-Costa M (Apr 2014). "Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis.". Lab Invest. 94 (4): 455–466. PMID 24492283. 

Further reading[edit]

  • Shukla SD (1992). "Platelet-activating factor receptor and signal transduction mechanisms.". FASEB J. 6 (6): 2296–301. PMID 1312046. 
  • Sugimoto T, Tsuchimochi H, McGregor CG, et al. (1993). "Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart.". Biochem. Biophys. Res. Commun. 189 (2): 617–24. doi:10.1016/0006-291X(92)92245-S. PMID 1281995. 
  • Seyfried CE, Schweickart VL, Godiska R, Gray PW (1992). "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1.". Genomics 13 (3): 832–4. doi:10.1016/0888-7543(92)90162-L. PMID 1322356. 
  • Kunz D, Gerard NP, Gerard C (1992). "The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog.". J. Biol. Chem. 267 (13): 9101–6. PMID 1374385. 
  • Ye RD, Prossnitz ER, Zou AH, Cochrane CG (1991). "Characterization of a human cDNA that encodes a functional receptor for platelet activating factor.". Biochem. Biophys. Res. Commun. 180 (1): 105–11. doi:10.1016/S0006-291X(05)81261-6. PMID 1656963. 
  • Nakamura M, Honda Z, Izumi T, et al. (1991). "Molecular cloning and expression of platelet-activating factor receptor from human leukocytes.". J. Biol. Chem. 266 (30): 20400–5. PMID 1657923. 
  • Haslam RJ, Williams KA, Davidson MM (1986). "Receptor-effector coupling in platelets: roles of guanine nucleotides.". Adv. Exp. Med. Biol. 192: 265–80. PMID 3010668. 
  • Valone FH (1984). "Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine.". Immunology 52 (1): 169–74. PMC 1454573. PMID 6325330. 
  • Cundell DR, Gerard NP, Gerard C, et al. (1995). "Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor.". Nature 377 (6548): 435–8. doi:10.1038/377435a0. PMID 7566121. 
  • Izumi T, Kishimoto S, Takano T, et al. (1995). "Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation.". Biochem. J. 305. ( Pt 3): 829–35. PMC 1136334. PMID 7848283. 
  • Bito H, Honda Z, Nakamura M, Shimizu T (1994). "Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA.". Eur. J. Biochem. 221 (1): 211–8. doi:10.1111/j.1432-1033.1994.tb18731.x. PMID 8168510. 
  • Chase PB, Halonen M, Regan JW (1993). "Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region.". Am. J. Respir. Cell Mol. Biol. 8 (3): 240–4. doi:10.1165/ajrcmb/8.3.240. PMID 8383507. 
  • Mutoh H, Bito H, Minami M, et al. (1993). "Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor.". FEBS Lett. 322 (2): 129–34. doi:10.1016/0014-5793(93)81552-B. PMID 8387031. 
  • Nakamura M, Honda Z, Matsumoto T, et al. (1993). "Isolation and properties of platelet-activating factor receptor cDNAs.". Journal of lipid mediators 6 (1-3): 163–8. PMID 8395240. 
  • Kishimoto S, Shimadzu W, Izumi T, et al. (1996). "Regulation by IL-5 of expression of functional platelet-activating factor receptors on human eosinophils.". J. Immunol. 157 (9): 4126–32. PMID 8892648. 
  • Chase PB, Yang JM, Thompson FH, et al. (1997). "Regional mapping of the human platelet-activating factor receptor gene (PTAFR) to 1p35→p34.3 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 72 (2-3): 205–7. doi:10.1159/000134190. PMID 8978777. 
  • Le Gouill C, Parent JL, Rola-Pleszczynski M, Stanková J (1997). "Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor.". FEBS Lett. 402 (2-3): 203–8. doi:10.1016/S0014-5793(96)01531-1. PMID 9037196. 
  • Ahmed A, Dearn S, Shams M, et al. (1998). "Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125.". FASEB J. 12 (10): 831–43. PMID 9657523. 
  • Cargill M, Altshuler D, Ireland J, et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes.". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.