Platelet-activating factor receptor

Platelet-activating factor receptor
Available structures PDB 2B0X
Identifiers
Symbols	PTAFR; PAFR
External IDs	OMIM: 173393 MGI: 106066 HomoloGene: 20260 IUPHAR: PAF receptor GeneCards: PTAFR Gene
Gene Ontology Molecular function • lipopolysaccharide binding • signal transducer activity • receptor activity • G-protein coupled receptor activity • platelet activating factor receptor activity • phospholipid binding Cellular component • nucleus • nucleolus • plasma membrane • plasma membrane • integral to plasma membrane • membrane • integral to membrane • intracellular membrane-bounded organelle Biological process • cytokine production • pattern recognition receptor signaling pathway • chemotaxis • inflammatory response • immune response • G-protein coupled receptor signaling pathway • cytokine-mediated signaling pathway • response to lipopolysaccharide • inositol trisphosphate biosynthetic process • phosphatidylinositol-mediated signaling • interferon-gamma-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5724	19204
Ensembl	ENSG00000169403	ENSMUSG00000056529
UniProt	P25105	Q62035
RefSeq (mRNA)	NM_000952.4	NM_001081211.1
RefSeq (protein)	NP_000943.1	NP_001074680.1
Location (UCSC)	Chr 1: 28.47 – 28.52 Mb	Chr 4: 132.12 – 132.14 Mb
PubMed search	[1]	[2]

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor.

The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM]

Further reading

• Shukla SD (1992). "Platelet-activating factor receptor and signal transduction mechanisms.". FASEB J. 6 (6): 2296–301. PMID 1312046. 
• Sugimoto T, Tsuchimochi H, McGregor CG, et al. (1993). "Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart.". Biochem. Biophys. Res. Commun. 189 (2): 617–24. doi:10.1016/0006-291X(92)92245-S. PMID 1281995. 
• Seyfried CE, Schweickart VL, Godiska R, Gray PW (1992). "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1.". Genomics 13 (3): 832–4. doi:10.1016/0888-7543(92)90162-L. PMID 1322356. 
• Kunz D, Gerard NP, Gerard C (1992). "The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog.". J. Biol. Chem. 267 (13): 9101–6. PMID 1374385. 
• Ye RD, Prossnitz ER, Zou AH, Cochrane CG (1991). "Characterization of a human cDNA that encodes a functional receptor for platelet activating factor.". Biochem. Biophys. Res. Commun. 180 (1): 105–11. doi:10.1016/S0006-291X(05)81261-6. PMID 1656963. 
• Nakamura M, Honda Z, Izumi T, et al. (1991). "Molecular cloning and expression of platelet-activating factor receptor from human leukocytes.". J. Biol. Chem. 266 (30): 20400–5. PMID 1657923. 
• Haslam RJ, Williams KA, Davidson MM (1986). "Receptor-effector coupling in platelets: roles of guanine nucleotides.". Adv. Exp. Med. Biol. 192: 265–80. PMID 3010668. 
• Valone FH (1984). "Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine.". Immunology 52 (1): 169–74. PMC 1454573. PMID 6325330. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1454573. 
• Cundell DR, Gerard NP, Gerard C, et al. (1995). "Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor.". Nature 377 (6548): 435–8. doi:10.1038/377435a0. PMID 7566121. 
• Izumi T, Kishimoto S, Takano T, et al. (1995). "Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation.". Biochem. J.. 305 ( Pt 3): 829–35. PMC 1136334. PMID 7848283. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1136334. 
• Bito H, Honda Z, Nakamura M, Shimizu T (1994). "Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA.". Eur. J. Biochem. 221 (1): 211–8. doi:10.1111/j.1432-1033.1994.tb18731.x. PMID 8168510. 
• Chase PB, Halonen M, Regan JW (1993). "Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region.". Am. J. Respir. Cell Mol. Biol. 8 (3): 240–4. PMID 8383507. 
• Mutoh H, Bito H, Minami M, et al. (1993). "Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor.". FEBS Lett. 322 (2): 129–34. doi:10.1016/0014-5793(93)81552-B. PMID 8387031. 
• Nakamura M, Honda Z, Matsumoto T, et al. (1993). "Isolation and properties of platelet-activating factor receptor cDNAs.". Journal of lipid mediators 6 (1-3): 163–8. PMID 8395240. 
• Kishimoto S, Shimadzu W, Izumi T, et al. (1996). "Regulation by IL-5 of expression of functional platelet-activating factor receptors on human eosinophils.". J. Immunol. 157 (9): 4126–32. PMID 8892648. 
• Chase PB, Yang JM, Thompson FH, et al. (1997). "Regional mapping of the human platelet-activating factor receptor gene (PTAFR) to 1p35→p34.3 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 72 (2-3): 205–7. doi:10.1159/000134190. PMID 8978777. 
• Le Gouill C, Parent JL, Rola-Pleszczynski M, Stanková J (1997). "Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor.". FEBS Lett. 402 (2-3): 203–8. doi:10.1016/S0014-5793(96)01531-1. PMID 9037196. 
• Ahmed A, Dearn S, Shams M, et al. (1998). "Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125.". FASEB J. 12 (10): 831–43. PMID 9657523. 
• Cargill M, Altshuler D, Ireland J, et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes.". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209. 

External links

• "Platelet-Activating Factor Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1348. 
• MeSH platelet+activating+factor+receptor

This article incorporates text from the United States National Library of Medicine, which is in the public domain.