Brain-specific angiogenesis inhibitor 2

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Brain-specific angiogenesis inhibitor 2
Identifiers
Symbol BAI2
External IDs OMIM602683 MGI2451244 HomoloGene1288 IUPHAR: BAI2 GeneCards: BAI2 Gene
RNA expression pattern
PBB GE BAI2 204966 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 576 230775
Ensembl ENSG00000121753 ENSMUSG00000028782
UniProt O60241 Q8CGM1
RefSeq (mRNA) NM_001294335 NM_001199696
RefSeq (protein) NP_001281264 NP_001186625
Location (UCSC) Chr 1:
32.19 – 32.23 Mb
Chr 4:
129.98 – 130.02 Mb
PubMed search [1] [2]

Brain-specific angiogenesis inhibitor 2 is a protein that in humans is encoded by the BAI2 gene.[1][2] It is a member of the adhesion-GPCR family of receptors. [3]

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.[2]


References[edit]

  1. ^ Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenet Cell Genet 79 (1-2): 103–8. doi:10.1159/000134693. PMID 9533023. 
  2. ^ a b "Entrez Gene: BAI2 brain-specific angiogenesis inhibitor 2". 
  3. ^ Stacey, edited by Simon Yona, Martin (2010). Adhesion-GPCRs : structure to function. New York: Springer Science+Business Media. ISBN 9781441979124. 

Further reading[edit]

  • Kreienkamp HJ, Zitzer H, Gundelfinger ED, et al. (2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins.". J. Biol. Chem. 275 (42): 32387–90. doi:10.1074/jbc.C000490200. PMID 10964907. 
  • Kee HJ, Koh JT, Kim MY, et al. (2002). "Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis.". J. Cereb. Blood Flow Metab. 22 (9): 1054–67. doi:10.1097/00004647-200209000-00003. PMID 12218411. 
  • Petersen HH, Hilpert J, Militz D, et al. (2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule.". J. Cell. Sci. 116 (Pt 3): 453–61. doi:10.1242/jcs.00243. PMID 12508107. 
  • Adkins JN, Varnum SM, Auberry KJ, et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry.". Mol. Cell Proteomics 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931. 
  • Nagaraja GM, Kandpal RP (2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.". Biochem. Biophys. Res. Commun. 313 (3): 654–65. doi:10.1016/j.bbrc.2003.12.001. PMID 14697242. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.". Genomics 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.