Neuropeptide Y receptor Y5

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Neuropeptide Y receptor Y5
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NPY5R ; NPY5-R; NPYR5; NPYY5-R
External IDs OMIM602001 MGI108082 HomoloGene21241 IUPHAR: Y5 ChEMBL: 4561 GeneCards: NPY5R Gene
RNA expression pattern
PBB GE NPY5R 207400 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4889 18168
Ensembl ENSG00000164129 ENSMUSG00000044014
UniProt Q15761 O70342
RefSeq (mRNA) NM_006174 NM_016708
RefSeq (protein) NP_006165 NP_057917
Location (UCSC) Chr 4:
164.27 – 164.27 Mb
Chr 8:
66.68 – 66.69 Mb
PubMed search [1] [2]

Neuropeptide Y receptor type 5 is a protein that in humans is encoded by the NPY5R gene.[1][2][3]


Selective Ligands[edit]

Agonists[edit]

  • Neuropeptide Y (endogenous agonist, non subtype selective)
  • BWX-46 (selective NPY5 agonist, CAS# 172997-92-1)
  • Peptide YY

Antagonists[edit]

  • CGP-71683 (CAS# 192322-50-2)
  • FMS-586[4]
  • L-152,804 (CAS# 6508-43-6)
  • Lu AA-33810[5]
  • MK-0557[6]
  • NTNCB (CAS# 486453-65-0)[7]

See also[edit]

References[edit]

  1. ^ Gerald C, Walker MW, Criscione L, Gustafson EL, Batzl-Hartmann C, Smith KE, Vaysse P, Durkin MM, Laz TM, Linemeyer DL, Schaffhauser AO, Whitebread S, Hofbauer KG, Taber RI, Branchek TA, Weinshank RL (Aug 1996). "A receptor subtype involved in neuropeptide-Y-induced food intake". Nature 382 (6587): 168–71. doi:10.1038/382168a0. PMID 8700207. 
  2. ^ Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (Feb 1998). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics 46 (2): 287–90. doi:10.1006/geno.1997.5024. PMID 9417917. 
  3. ^ "Entrez Gene: NPY5R neuropeptide Y receptor Y5". 
  4. ^ Kakui N, Tanaka J, Tabata Y, Asai K, Masuda N, Miyara T, Nakatani Y, Ohsawa F, Nishikawa N, Sugai M, Suzuki M, Aoki K, Kitaguchi H (May 2006). "Pharmacological characterization and feeding-suppressive property of FMS586 [3-(5,6,7,8-tetrahydro-9-isopropyl-carbazol-3-yl)-1-methyl-1-(2-pyridin-4-yl-ethyl)-urea hydrochloride], a novel, selective, and orally active antagonist for neuropeptide Y Y5 receptor". The Journal of Pharmacology and Experimental Therapeutics 317 (2): 562–70. doi:10.1124/jpet.105.099705. PMID 16436501. 
  5. ^ Walker MW, Wolinsky TD, Jubian V, Chandrasena G, Zhong H, Huang X, Miller S, Hegde LG, Marsteller DA, Marzabadi MR, Papp M, Overstreet DH, Gerald CP, Craig DA (March 2009). "The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 (N-([trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl)-methanesulfonamide) exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity". The Journal of Pharmacology and Experimental Therapeutics 328 (3): 900–11. doi:10.1124/jpet.108.144634. PMID 19098165. 
  6. ^ MacNeil DJ (2007). "NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs". Current Topics in Medicinal Chemistry 7 (17): 1721–33. doi:10.2174/156802607782341028. PMID 17979781. 
  7. ^ Islam I, Dhanoa D, Finn J, Du P, Walker MW, Salon JA, Zhang J, Gluchowski C (July 2002). "Discovery of potent and selective small molecule NPY Y5 receptor antagonists". Bioorganic & Medicinal Chemistry Letters 12 (13): 1767–9. doi:10.1016/S0960-894X(02)00287-1. PMID 12067557. 

External links[edit]

Further reading[edit]