Neuropeptide Y receptor Y5

From Wikipedia, the free encyclopedia

Jump to: navigation, search
edit
Neuropeptide Y receptor Y5
Identifiers
Symbols NPY5R; NPYR5
External IDs OMIM: 602001 MGI: 108082 HomoloGene: 21241
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4889 18168
Ensembl ENSG00000164129 ENSMUSG00000044014
Uniprot Q15761 Q543U8
Refseq NM_006174 (mRNA)
NP_006165 (protein)		 NM_016708 (mRNA)
NP_057917 (protein)
Location Chr 4: 164.48 - 164.49 Mb Chr 8: 69.61 - 69.62 Mb
Pubmed search [1] [2]

Neuropeptide Y receptor Y5, also known as NPY5R, is a human gene.[1]


Contents

[edit] Selective Ligands

[edit] Agonists

  • Neuropeptide Y (endogenous agonist, non subtype selective)
  • BWX-46 (selective NPY5 agonist, CAS# 172997-92-1)

[edit] Antagonists

  • CGP-71683 (CAS# 192322-50-2)
  • FMS-586[2]
  • L-152,804 (CAS# 6508-43-6)
  • Lu AA-33810[3]
  • MK-0557[4]
  • NTNCB (CAS# 486453-65-0)[5]

[edit] See also

[edit] References

  1. ^ "Entrez Gene: NPY5R neuropeptide Y receptor Y5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4889. 
  2. ^ Kakui N, Tanaka J, Tabata Y, Asai K, Masuda N, Miyara T, Nakatani Y, Ohsawa F, Nishikawa N, Sugai M, Suzuki M, Aoki K, Kitaguchi H (May 2006). "Pharmacological characterization and feeding-suppressive property of FMS586 [3-(5,6,7,8-tetrahydro-9-isopropyl-carbazol-3-yl)-1-methyl-1-(2-pyridin-4-yl-ethyl)-urea hydrochloride], a novel, selective, and orally active antagonist for neuropeptide Y Y5 receptor". The Journal of Pharmacology and Experimental Therapeutics 317 (2): 562–70. doi:10.1124/jpet.105.099705. PMID 16436501. 
  3. ^ Walker MW, Wolinsky TD, Jubian V, Chandrasena G, Zhong H, Huang X, Miller S, Hegde LG, Marsteller DA, Marzabadi MR, Papp M, Overstreet DH, Gerald CP, Craig DA (March 2009). "The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 (N-([trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl)-methanesulfonamide) exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity". The Journal of Pharmacology and Experimental Therapeutics 328 (3): 900–11. doi:10.1124/jpet.108.144634. PMID 19098165. 
  4. ^ MacNeil DJ (2007). "NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs". Current Topics in Medicinal Chemistry 7 (17): 1721–33. doi:10.2174/156802607782341028. PMID 17979781. http://www.bentham-direct.org/pages/content.php?CTMC/2007/00000007/00000017/0009R.SGM. 
  5. ^ Islam I, Dhanoa D, Finn J, Du P, Walker MW, Salon JA, Zhang J, Gluchowski C (July 2002). "Discovery of potent and selective small molecule NPY Y5 receptor antagonists". Bioorganic & Medicinal Chemistry Letters 12 (13): 1767–9. doi:10.1016/S0960-894X(02)00287-1. PMID 12067557. http://linkinghub.elsevier.com/retrieve/pii/S0960894X02002871. 

[edit] External links

[edit] Further reading

  • Parker E, Van Heek M, Stamford A (2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.". Eur. J. Pharmacol. 440 (2-3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534. 
  • Gerald C, Walker MW, Criscione L, et al. (1996). "A receptor subtype involved in neuropeptide-Y-induced food intake.". Nature 382 (6587): 168–71. doi:10.1038/382168a0. PMID 8700207. 
  • Hu Y, Bloomquist BT, Cornfield LJ, et al. (1996). "Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.". J. Biol. Chem. 271 (42): 26315–9. doi:10.1074/jbc.271.42.26315. PMID 8824284. 
  • Herzog H, Darby K, Ball H, et al. (1997). "Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation.". Genomics 41 (3): 315–9. doi:10.1006/geno.1997.4684. PMID 9169127. 
  • Lutz CM, Richards JE, Scott KL, et al. (1998). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY.". Genomics 46 (2): 287–90. doi:10.1006/geno.1997.5024. PMID 9417917. 
  • Nichol KA, Morey A, Couzens MH, et al. (1999). "Conservation of expression of neuropeptide Y5 receptor between human and rat hypothalamus and limbic regions suggests an integral role in central neuroendocrine control.". J. Neurosci. 19 (23): 10295–304. PMID 10575027. 
  • Rodriguez M, Audinot V, Dromaint S, et al. (2003). "Molecular identification of the long isoform of the human neuropeptide Y Y5 receptor and pharmacological comparison with the short Y5 receptor isoform.". Biochem. J. 369 (Pt 3): 667–73. doi:10.1042/BJ20020739. PMID 12398768. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Berglund MM, Schober DA, Statnick MA, et al. (2003). "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction.". J. Pharmacol. Exp. Ther. 306 (1): 147–56. doi:10.1124/jpet.103.051227. PMID 12665544. 
  • Beauverger P, Rodriguez M, Nicolas JP, et al. (2005). "Functional characterization of human neuropeptide Y receptor subtype five specific antagonists using a luciferase reporter gene assay.". Cell. Signal. 17 (4): 489–96. doi:10.1016/j.cellsig.2004.09.006. PMID 15601626. 
  • Movafagh S, Hobson JP, Spiegel S, et al. (2006). "Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors.". FASEB J. 20 (11): 1924–6. doi:10.1096/fj.05-4770fje. PMID 16891622. 
  • Coletta DK, Schneider J, Stern MP, et al. (2007). "Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans.". Obesity (Silver Spring, Md.) 15 (4): 809–15. doi:10.1038/oby.2007.610. PMID 17426313. 
 This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.
v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182)
Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) · Adrenomedullin · Anaphylatoxin (C3a, C5a) · Angiotensin (1, 2) · Apelin · Bile acid · Bombesin (BRS3, GRPR, NMBR) · Bradykinin (B1, B2) · Cannabinoid (CB1, CB2) · Chemokine · Cholecystokinin (A, B) · Dopamine (D1, D2, D3, D4, D5) · EBI2 · Endothelin (A, B) · Estrogen · Formyl peptide (1, L1, L2) · Free fatty acid (1, 2, 3, 4) · FSH · Galanin (1, 2, 3) · Gonadotropin-releasing hormone (1, 2) · GHB receptor · Ghrelin · Histamine (H1, H2, H3, H4) · Kisspeptin · Luteinizing hormone/choriogonadotropin · lysophosphatidic acid (1, 2, 3)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortin (1, 2, 3, 4, 5) · MCHR (1, 2) · Melatonin (1A, 1B, 1C) · Niacin (1, 2) · Motilin · Opioid (Delta, Kappa, Mu, Nociceptin & Zeta, but not Sigma) · Olfactory · Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Orexin (1, 2) · Oxytocin · Oxoglutarate · PAF · Prokineticin (1, 2) · Prolactin-releasing peptide · Protease-activated (1, 2, 3, 4) · Relaxin (1, 2, 3, 4) · Somatostatin (1, 2, 3, 4, 5) · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · SREB · Succinate · TAAR (1, 2, 3, 5, 6, 8, 9) · Tachykinin (1, 2, 3) · Thyrotropin · Thyrotropin-releasing hormone · Urotensin-II · Vasopressin (1A, 1B, 2)
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50)
Other
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) · Smoothened
Retrieved from "http://en.wikipedia.org/wiki/Neuropeptide_Y_receptor_Y5"
Personal tools