GPR132

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G protein-coupled receptor 132
Identifiers
Symbols GPR132 ; G2A
External IDs OMIM606167 MGI1890220 HomoloGene8350 IUPHAR: GPR132 GeneCards: GPR132 Gene
RNA expression pattern
PBB GE GPR132 221140 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 29933 56696
Ensembl ENSG00000183484 ENSMUSG00000021298
UniProt Q9UNW8 Q9Z282
RefSeq (mRNA) NM_001278694 NM_019925
RefSeq (protein) NP_001265623 NP_064309
Location (UCSC) Chr 14:
105.52 – 105.53 Mb
Chr 12:
112.85 – 112.86 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 132 is a protein that in humans is encoded by the GPR132 gene.[1][2]

This gene encodes a subfamily member of the G-protein couple receptor (GPCR) superfamily. The encoded protein is a high-affinity receptor for lysophosphatidylcholine (LPC), a major phospholipid component of oxidized low density lipoprotein. This protein may react to LPC levels at sites of inflammation to limit the expansion of tissue-infiltrating cells. A similar protein in mouse is involved in cell cycle progression.[2]

See also[edit]

References[edit]

  1. ^ Le LQ, Kabarowski JH, Wong S, Nguyen K, Gambhir SS, Witte ON (Jun 2002). "Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene". Cancer Cell 1 (4): 381–91. doi:10.1016/S1535-6108(02)00058-2. PMID 12086852. 
  2. ^ a b "Entrez Gene: GPR132 G protein-coupled receptor 132". 

Further reading[edit]