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G protein-coupled receptor, class C, group 5, member B
Symbols GPRC5B ; RAIG-2; RAIG2
External IDs OMIM605948 MGI1927596 HomoloGene9435 IUPHAR: 259 GeneCards: GPRC5B Gene
RNA expression pattern
PBB GE GPRC5B 203632 s at tn.png
PBB GE GPRC5B 203631 s at tn.png
More reference expression data
Species Human Mouse
Entrez 51704 64297
Ensembl ENSG00000167191 ENSMUSG00000008734
UniProt Q9NZH0 Q923Z0
RefSeq (mRNA) NM_016235 NM_001195774
RefSeq (protein) NP_057319 NP_001182703
Location (UCSC) Chr 16:
19.87 – 19.9 Mb
Chr 7:
118.97 – 119 Mb
PubMed search [1] [2]

G-protein coupled receptor family C group 5 member B is a protein that in humans is encoded by the GPRC5B gene.[1][2][3]


The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade.[3]

See also[edit]


  1. ^ Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Nov 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829. 
  2. ^ Bräuner-Osborne H, Krogsgaard-Larsen P (Jul 2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259. 
  3. ^ a b "Entrez Gene: GPRC5B G protein-coupled receptor, family C, group 5, member B". 

Further reading[edit]

  • Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2001). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465. 

External links[edit]

  • "GPRC5 Receptors: RAIG2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.