Galanin receptor 2

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Galanin receptor 2
Identifiers
Symbols GALR2 ; GAL2-R; GALNR2; GALR-2
External IDs OMIM603691 MGI1337018 HomoloGene2863 IUPHAR: GAL2 ChEMBL: 3176 GeneCards: GALR2 Gene
RNA expression pattern
PBB GE GALR2 211226 at tn.png
PBB GE GALR2 gnf1h09841 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8811 14428
Ensembl ENSG00000182687 ENSMUSG00000020793
UniProt O43603 O88854
RefSeq (mRNA) NM_003857 NM_010254
RefSeq (protein) NP_003848 NP_034384
Location (UCSC) Chr 17:
74.07 – 74.07 Mb
Chr 11:
116.28 – 116.28 Mb
PubMed search [1] [2]

Galanin receptor 2, (GAL2) is a G-protein coupled receptor encoded by the GALR2 gene.[1]

Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.[1]

See also[edit]

References[edit]

External links[edit]

  • "Galanin Receptors: GAL2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.