Angiotensin II receptor type 1

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Angiotensin II receptor, type 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols AGTR1 ; AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR; AT1R; AT2R1; HAT1R
External IDs OMIM106165 MGI87964 HomoloGene3556 IUPHAR: AT1 ChEMBL: 227 GeneCards: AGTR1 Gene
RNA expression pattern
PBB GE AGTR1 205357 s at tn.png
PBB GE AGTR1 208016 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 185 11607
Ensembl ENSG00000144891 ENSMUSG00000049115
UniProt P30556 P29754
RefSeq (mRNA) NM_000685 NM_177322
RefSeq (protein) NP_000676 NP_796296
Location (UCSC) Chr 3:
148.42 – 148.46 Mb
Chr 13:
30.34 – 30.38 Mb
PubMed search [1] [2]

Angiotensin II receptor, type 1 or AT1 receptor is an angiotensin receptor. It has vasopressor effects and regulates aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. Angiotensin II receptor antagonists are drugs indicated for hypertension, diabetic nephropathy and congestive heart failure.

It is the best elucidated angiotensin receptor.

Mechanism[edit]

The angiotensin receptor is activated by the vasoconstricting peptide angiotensin II. The activated receptor in turn couples to Gq/11 and thus activates phospholipase C and increases the cytosolic Ca2+ concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. Activated receptor also inhibits adenylate cyclase and activates various tyrosine kinases.[1]

Effects[edit]

The AT1 receptor mediates the major cardiovascular effects of angiotensin II. Effects include vasoconstriction, aldosterone synthesis and secretion, increased vasopressin secretion, cardiac hypertrophy, augmentation of peripheral noradrenergic activity, vascular smooth muscle cells proliferation, decreased renal blood flow, renal renin inhibition, renal tubular sodium reuptake, modulation of central sympathetic nervous system activity, cardiac contractility, central osmocontrol and extracellular matrix formation.[2]

Pathology[edit]

The AT1 receptor may play role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium.

Gene[edit]

It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least four transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants.[3]

Interactions[edit]

Angiotensin II receptor type 1 has been shown to interact with Zinc finger and BTB domain-containing protein 16.[4] The protein's mRNA has been reported to interact with Mir-132 microRNA as part of an RNA silencing mechanism that reduces receptor expression.[5]

References[edit]

  1. ^ Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S (2007). "Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology". Clin. Sci. 112 (8): 417–28. doi:10.1042/CS20060342. PMID 17346243. 
  2. ^ Catt KJ, Mendelsohn FA, Millan MA, Aguilera G (1984). "The role of angiotensin II receptors in vascular regulation". J. Cardiovasc. Pharmacol. 6 (Suppl 4): S575–86. doi:10.1097/00005344-198406004-00004. PMID 6083400. 
  3. ^ "Entrez Gene: AGTR1 angiotensin II receptor, type 1". 
  4. ^ Senbonmatsu T, Saito T, Landon EJ, Watanabe O, Price E, Roberts RL, Imboden H, Fitzgerald TG, Gaffney FA, Inagami T (2003). "A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy". EMBO J. 22 (24): 6471–82. doi:10.1093/emboj/cdg637. PMC 291832. PMID 14657020. 
  5. ^ Elton TS, Kuhn DE, Malana GE, Martin MM, Nuovo GJ, Pleister AP, Feldman DS (2007). "MiR-132 Regulates Angiotensin II Type 1 Receptor Expression Through a Protein Coding Region Binding Site". Circulation 118 (18): S513. 

External links[edit]

Further reading[edit]

  • Matsusaka T, Ichikawa I (1997). "Biological functions of angiotensin and its receptors.". Annu. Rev. Physiol. 59: 395–412. doi:10.1146/annurev.physiol.59.1.395. PMID 9074770. 
  • Allen AM, Moeller I, Jenkins TA, et al. (1998). "Angiotensin receptors in the nervous system.". Brain Res. Bull. 47 (1): 17–28. doi:10.1016/S0361-9230(98)00039-2. PMID 9766385. 
  • Berry C, Touyz R, Dominiczak AF, et al. (2002). "Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide.". Am. J. Physiol. Heart Circ. Physiol. 281 (6): H2337–65. PMID 11709400. 
  • Arima S, Ito S (2001). "New insights into actions of the renin-angiotensin system in the kidney: concentrating on the Ang II receptors and the newly described Ang-(1-7) and its receptor.". Semin. Nephrol. 21 (6): 535–43. doi:10.1053/snep.2001.26792. PMID 11709801. 
  • Stowasser M, Gunasekera TG, Gordon RD (2002). "Familial varieties of primary aldosteronism.". Clin. Exp. Pharmacol. Physiol. 28 (12): 1087–90. doi:10.1046/j.1440-1681.2001.03574.x. PMID 11903322. 
  • Padmanabhan N, Padmanabhan S, Connell JM (2002). "Genetic basis of cardiovascular disease--the renin-angiotensin-aldosterone system as a paradigm.". Journal of the renin-angiotensin-aldosterone system : JRAAS 1 (4): 316–24. doi:10.3317/jraas.2000.060. PMID 11967817. 
  • Thibonnier M, Coles P, Thibonnier A, Shoham M (2002). "Chapter 14 Molecular pharmacology and modeling of vasopressin receptors". "Molecular pharmacology and modeling of vasopressin receptors.". Prog. Brain Res. Progress in Brain Research 139: 179–96. doi:10.1016/S0079-6123(02)39016-2. ISBN 978-0-444-50982-6. PMID 12436935. 
  • Elton TS, Martin MM (2003). "Alternative splicing: a novel mechanism to fine-tune the expression and function of the human AT1 receptor". Trends Endocrinol. Metab. 14 (2): 66–71. doi:10.1016/S1043-2760(02)00038-3. PMID 12591176. 
  • Saavedra JM, Benicky J, Zhou J (2007). "Mechanisms of the Anti-Ischemic Effect of Angiotensin II AT( 1 ) Receptor Antagonists in the Brain". Cell. Mol. Neurobiol. 26 (7–8): 1099–111. doi:10.1007/s10571-006-9009-0. PMID 16636899. 
  • Oliveira L, Costa-Neto CM, Nakaie CR, et al. (2007). "The angiotensin II AT1 receptor structure-activity correlations in the light of rhodopsin structure". Physiol. Rev. 87 (2): 565–92. doi:10.1152/physrev.00040.2005. PMID 17429042. 
  • Ariza AC, Bobadilla NA, Halhali A (2007). "[Endothelin 1 and angiotensin II in preeeclampsia]". Rev. Invest. Clin. 59 (1): 48–56. PMID 17569300. 
  • Xia Y, Zhou CC, Ramin SM, Kellems RE (2007). "Angiotensin receptors, autoimmunity, and preeclampsia". J. Immunol. 179 (6): 3391–5. doi:10.4049/jimmunol.179.6.3391. PMC 3262172. PMID 17785770. 
  • Mauzy CA, Hwang O, Egloff AM, et al. (1992). "Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor". Biochem. Biophys. Res. Commun. 186 (1): 277–84. doi:10.1016/S0006-291X(05)80804-6. PMID 1378723. 
  • Curnow KM, Pascoe L, White PC (1992). "Genetic analysis of the human type-1 angiotensin II receptor". Mol. Endocrinol. 6 (7): 1113–8. doi:10.1210/me.6.7.1113. PMID 1508224. 
  • Furuta H, Guo DF, Inagami T (1992). "Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor". Biochem. Biophys. Res. Commun. 183 (1): 8–13. doi:10.1016/0006-291X(92)91600-U. PMID 1543512. 
  • Takayanagi R, Ohnaka K, Sakai Y, et al. (1992). "Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor". Biochem. Biophys. Res. Commun. 183 (2): 910–6. doi:10.1016/0006-291X(92)90570-B. PMID 1550596. 
  • Bergsma DJ, Ellis C, Kumar C, et al. (1992). "Cloning and characterization of a human angiotensin II type 1 receptor". Biochem. Biophys. Res. Commun. 183 (3): 989–95. doi:10.1016/S0006-291X(05)80288-8. PMID 1567413. 
  • Gemmill RM, Drabkin HA (1992). "Report of the Second International Workshop on Human Chromosome 3 mapping". Cytogenet. Cell Genet. 57 (4): 162–6. doi:10.1159/000133138. PMID 1683828. 
  • Curnow KM, Pascoe L, Davies E, et al. (1996). "Alternatively spliced human type 1 angiotensin II receptor mRNAs are translated at different efficiencies and encode two receptor isoforms". Mol. Endocrinol. 9 (9): 1250–62. doi:10.1210/me.9.9.1250. PMID 7491117. 
  • Marrero MB, Schieffer B, Paxton WG, et al. (1995). "Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor". Nature 375 (6528): 247–50. doi:10.1038/375247a0. PMID 7746328. 


This article incorporates text from the United States National Library of Medicine, which is in the public domain.