TAS2R31

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Taste receptor, type 2, member 31
Identifiers
Symbols TAS2R31 ; T2R31; T2R44; T2R53; TAS2R44
External IDs OMIM612669 MGI2681304 HomoloGene136304 IUPHAR: TAS2R31 GeneCards: TAS2R31 Gene
Orthologs
Species Human Mouse
Entrez 259290 353165
Ensembl ENSG00000256436 ENSMUSG00000053217
UniProt P59538 Q7TQA8
RefSeq (mRNA) NM_176885 NM_181276
RefSeq (protein) NP_795366 NP_851793
Location (UCSC) Chr 12:
11.18 – 11.18 Mb
Chr 6:
132.78 – 132.78 Mb
PubMed search [1] [2]

Taste receptor, type 2, member 31, also known as TAS2R31, is a protein which in humans is encoded by the TAS2R31 gene.[1] This bitter taste receptor has been shown to respond to saccharin in vitro.[2]

TAS2R31 is also expressed in the smooth muscle of human airways, along with several other bitter taste receptors. Their activation in these cells causes an increase in intracellular calcium ion, which in turn triggers the opening of potassium channels which hyperpolarize the membrane and cause the smooth muscle to relax. Hence, activation of these receptors leads to bronchodilation.[3][3]

Polymorphisms in this gene have been associated with the perceived bitterness of sweetener acesulfame potassium.[4]

See also[edit]

References[edit]

  1. ^ "Entrez Gene: TAS2R31 taste receptor, type 2, member 31". 
  2. ^ Kuhn C, Bufe B, Winnig M, Hofmann T, Frank O, Behrens M, Lewtschenko T, Slack JP, Ward CD, Meyerhof W (November 2004). "Bitter taste receptors for saccharin and acesulfame K". J. Neurosci. 24 (45): 10260–5. doi:10.1523/JNEUROSCI.1225-04.2004. PMID 15537898. 
  3. ^ a b Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB (November 2010). "Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction". Nat. Med. 16 (11): 1299–304. doi:10.1038/nm.2237. PMC 3066567. PMID 20972434. 
  4. ^ Allen AL, McGeary JE, Knopik VS, Hayes JE (2013). "Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31". Chem. Senses 38 (5): 379–89. doi:10.1093/chemse/bjt017. PMC 3657735. PMID 23599216. 

Further reading[edit]

  • Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction.". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554. 
  • Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste.". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982. 
  • Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.". Nat. Genet. 32 (3): 397–401. doi:10.1038/ng1014. PMID 12379855. 
  • Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.". Cell 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520. 
  • Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ (2003). "Identification and characterization of human taste receptor genes belonging to the TAS2R family.". Cytogenet. Genome Res. 98 (1): 45–53. doi:10.1159/000068546. PMID 12584440. 
  • Pronin AN, Tang H, Connor J, Keung W (2005). "Identification of ligands for two human bitter T2R receptors.". Chem. Senses 29 (7): 583–93. doi:10.1093/chemse/bjh064. PMID 15337684. 
  • Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes.". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549. 
  • Kuhn C, Bufe B, Winnig M, Hofmann T, Frank O, Behrens M, Lewtschenko T, Slack JP, Ward CD, Meyerhof W (2005). "Bitter taste receptors for saccharin and acesulfame K.". J. Neurosci. 24 (45): 10260–5. doi:10.1523/JNEUROSCI.1225-04.2004. PMID 15537898. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.