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Frizzled class receptor 3
Symbols FZD3 ; Fz-3
External IDs OMIM606143 MGI108476 HomoloGene23004 IUPHAR: FZD3 GeneCards: FZD3 Gene
RNA expression pattern
PBB GE FZD3 219683 at tn.png
More reference expression data
Species Human Mouse
Entrez 7976 14365
Ensembl ENSG00000104290 ENSMUSG00000007989
UniProt Q9NPG1 Q61086
RefSeq (mRNA) NM_017412 NM_021458
RefSeq (protein) NP_059108 NP_067433
Location (UCSC) Chr 8:
28.35 – 28.43 Mb
Chr 14:
65.2 – 65.26 Mb
PubMed search [1] [2]

Frizzled-3 is a protein that in humans is encoded by the FZD3 gene.[1][2][3]

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development.[3]

See also[edit]


  1. ^ Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M (Jun 2000). "Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21". Biochem Biophys Res Commun 271 (1): 8–14. doi:10.1006/bbrc.2000.2578. PMID 10777673. 
  2. ^ Sala CF, Formenti E, Terstappen GC, Caricasole A (Jul 2000). "Identification, gene structure, and expression of human frizzled-3 (FZD3)". Biochem Biophys Res Commun 273 (1): 27–34. doi:10.1006/bbrc.2000.2882. PMID 10873558. 
  3. ^ a b "Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)". 

External links[edit]

  • "Frizzled Receptors: FZD3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.