GABBR2

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Gamma-aminobutyric acid (GABA) B receptor, 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GABBR2 ; GABABR2; GPR51; GPRC3B; HG20; HRIHFB2099
External IDs OMIM607340 MGI2386030 HomoloGene55902 IUPHAR: GABAB2 ChEMBL: 5034 GeneCards: GABBR2 Gene
RNA expression pattern
PBB GE GABBR2 209990 s at tn.png
PBB GE GABBR2 209991 x at tn.png
PBB GE GABBR2 211679 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9568 242425
Ensembl ENSG00000136928 ENSMUSG00000039809
UniProt O75899 Q80T41
RefSeq (mRNA) NM_005458 NM_001081141
RefSeq (protein) NP_005449 NP_001074610
Location (UCSC) Chr 9:
101.05 – 101.47 Mb
Chr 4:
46.66 – 46.99 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid (GABA) B receptor, 2 (GABAB2) is a G-protein coupled receptor subunit encoded by the GABBR2 gene in humans.[1]

Function[edit]

B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. See GABBR1 (MIM 603540) for additional background information on GABA-B receptors.[supplied by OMIM][1]

Interactions[edit]

GABBR2 has been shown to interact with GABBR1.[2]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2". 
  2. ^ White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH (Dec 1998). "Heterodimerization is required for the formation of a functional GABA(B) receptor". Nature 396 (6712): 679–82. doi:10.1038/25354. PMID 9872316. 

Further reading[edit]

  • White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH (1999). "Heterodimerization is required for the formation of a functional GABA(B) receptor". Nature 396 (6712): 679–82. doi:10.1038/25354. PMID 9872316. 
  • Ng GY, Clark J, Coulombe N, Ethier N, Hebert TE, Sullivan R, Kargman S, Chateauneuf A, Tsukamoto N, McDonald T, Whiting P, Mezey E, Johnson MP, Liu Q, Kolakowski LF, Evans JF, Bonner TI, O'Neill GP (1999). "Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity". J. Biol. Chem. 274 (12): 7607–10. doi:10.1074/jbc.274.12.7607. PMID 10075644. 
  • Ng GY, McDonald T, Bonnert T, Rigby M, Heavens R, Whiting P, Chateauneuf A, Coulombe N, Kargman S, Caskey T, Evans J, O'neill GP, Liu Q (1999). "Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9". Genomics 56 (3): 288–95. doi:10.1006/geno.1998.5706. PMID 10087195. 
  • Martin SC, Russek SJ, Farb DH (1999). "Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1". Mol. Cell. Neurosci. 13 (3): 180–91. doi:10.1006/mcne.1999.0741. PMID 10328880. 
  • Clark JA, Mezey E, Lam AS, Bonner TI (2000). "Distribution of the GABA(B) receptor subunit gb2 in rat CNS". Brain Res. 860 (1–2): 41–52. doi:10.1016/S0006-8993(00)01958-2. PMID 10727622. 
  • Sullivan R, Chateauneuf A, Coulombe N, Kolakowski LF, Johnson MP, Hebert TE, Ethier N, Belley M, Metters K, Abramovitz M, O'Neill GP, Ng GY (2000). "Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor". J. Pharmacol. Exp. Ther. 293 (2): 460–7. PMID 10773016. 
  • White JH, McIllhinney RA, Wise A, Ciruela F, Chan WY, Emson PC, Billinton A, Marshall FH (2001). "The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13967–72. doi:10.1073/pnas.240452197. PMC 17684. PMID 11087824. 
  • Kitano J, Kimura K, Yamazaki Y, Soda T, Shigemoto R, Nakajima Y, Nakanishi S (2002). "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins". J. Neurosci. 22 (4): 1280–9. PMID 11850456. 
  • Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, Watts E, Kerby J, Heald A, Beer M, McAllister G, Guest PC (2002). "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation". J. Biol. Chem. 277 (18): 15482–5. doi:10.1074/jbc.M201539200. PMID 11854302. 
  • Furtinger S, Pirker S, Czech T, Baumgartner C, Sperk G (2004). "Increased expression of gamma-aminobutyric acid type B receptors in the hippocampus of patients with temporal lobe epilepsy". Neurosci. Lett. 352 (2): 141–5. doi:10.1016/j.neulet.2003.08.046. PMID 14625043. 
  • Waldvogel HJ, Billinton A, White JH, Emson PC, Faull RL (2004). "Comparative cellular distribution of GABAA and GABAB receptors in the human basal ganglia: immunohistochemical colocalization of the alpha 1 subunit of the GABAA receptor, and the GABABR1 and GABABR2 receptor subunits". J. Comp. Neurol. 470 (4): 339–56. doi:10.1002/cne.20005. PMID 14961561. 
  • Balasubramanian S, Teissére JA, Raju DV, Hall RA (2004). "Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking". J. Biol. Chem. 279 (18): 18840–50. doi:10.1074/jbc.M313470200. PMID 14966130. 
  • Uezono Y, Kaibara M, Hayashi H, Kawakami S, Enjoji A, Kanematsu T, Taniyama K (2004). "Characterization of GABAB receptor in the human colon". J. Pharmacol. Sci. 94 (2): 211–3. doi:10.1254/jphs.94.211. PMID 14978362. 
  • Hlavackova V, Goudet C, Kniazeff J, Zikova A, Maurel D, Vol C, Trojanova J, Prézeau L, Pin JP, Blahos J (2005). "Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR". EMBO J. 24 (3): 499–509. doi:10.1038/sj.emboj.7600557. PMC 548662. PMID 15660124. 
  • DeGiorgis JA, Jaffe H, Moreira JE, Carlotti CG, Leite JP, Pant HC, Dosemeci A (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". J. Proteome Res. 4 (2): 306–15. doi:10.1021/pr0498436. PMID 15822905. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Osawa Y, Xu D, Sternberg D, Sonett JR, D'Armiento J, Panettieri RA, Emala CW (2006). "Functional expression of the GABAB receptor in human airway smooth muscle". Am. J. Physiol. Lung Cell Mol. Physiol. 291 (5): L923–31. doi:10.1152/ajplung.00185.2006. PMID 16829628. 

External links[edit]

  • "GABAB Receptors: GABAB2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.