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G protein-coupled receptor 64
Symbols GPR64 ; EDDM6; HE6; TM7LN2
External IDs OMIM300572 MGI2446854 HomoloGene4208 IUPHAR: GPR64 GeneCards: GPR64 Gene
RNA expression pattern
PBB GE GPR64 206002 at tn.png
More reference expression data
Species Human Mouse
Entrez 10149 237175
Ensembl ENSG00000173698 ENSMUSG00000031298
UniProt Q8IZP9 Q8CJ12
RefSeq (mRNA) NM_001079858 NM_001079847
RefSeq (protein) NP_001073327 NP_001073316
Location (UCSC) Chr X:
19.01 – 19.14 Mb
Chr X:
160.39 – 160.5 Mb
PubMed search [1] [2]

G-protein coupled receptor 64 Is a protein that in humans is encoded by the GPR64 gene. The gene product is a member of the It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[1][2] [3][4][5][6]

The adhesion GPCR, GPR64, is an orphan receptor characterized by a long N-terminus with that has been suggested to be highly glycosylated.[7] GPR64's N-terminus has been reported to be cleaved at the GPS domain to allow for trafficking to the plasma membrane. After cleavage the N-terminus is believed to remain non-covalently associated with the 7TM. Male mice lacking GPR64 are infertile.

GPR64 expression has been mostly reported in the male reproductive organs, but more recently has been shown to be expressed in the central nervous system.[8]


  1. ^ Yona, Stacey (2011). Adhesion-GPCRs. 1-200: Springer. ISBN 978-1-4419-7912-4. 
  2. ^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. 
  3. ^ Araç, D; Boucard, AA; Bolliger, MF; Nguyen, J; Soltis, SM; Südhof, TC; Brunger, AT (Feb 14, 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.". The EMBO Journal 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. 
  4. ^ Kirchhoff C, Osterhoff C, Pera I, Schroter S (Jan 1999). "Function of human epididymal proteins in sperm maturation". Andrologia 30 (4–5): 225–32. doi:10.1111/j.1439-0272.1998.tb01164.x. PMID 9739419. 
  5. ^ Osterhoff C, Ivell R, Kirchhoff C (Jun 1997). "Cloning of a human epididymis-specific mRNA, HE6, encoding a novel member of the seven transmembrane-domain receptor superfamily". DNA Cell Biol 16 (4): 379–89. doi:10.1089/dna.1997.16.379. PMID 9150425. 
  6. ^ "Entrez Gene: GPR64 G protein-coupled receptor 64". 
  7. ^ Davies B, Baumann C, Kirchhoff C, Ivell R, Nubbemeyer R, Habenicht UF, Theuring F, Gottwald U. Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility" Mol Cell Biol 2004; 24: 8642 8648
  8. ^ Haitina T, Olsson F, Stephansson O, Alsiö J, Roman E, Ebendal T, Schiöth HB, Fredriksson R. Expression profile of the entire family of Adhesion G protein-coupled receptors in mouse and rat. BMC Neurosci. 2008;9:43–43. doi:10.1186/1471-2202-9-43

Further reading[edit]

  • Obermann H, Samalecos A, Osterhoff C, et al. (2003). "HE6, a two-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia". Mol. Reprod. Dev. 64 (1): 13–26. doi:10.1002/mrd.10220. PMID 12420295. 

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