GPR183

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G protein-coupled receptor 183
Identifiers
Symbols GPR183 ; EBI2
External IDs OMIM605741 MGI2442034 HomoloGene28066 IUPHAR: GPR183 GeneCards: GPR183 Gene
RNA expression pattern
PBB GE EBI2 205419 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1880 321019
Ensembl ENSG00000169508 ENSMUSG00000051212
UniProt P32249 Q3U6B2
RefSeq (mRNA) NM_004951 NM_183031
RefSeq (protein) NP_004942 NP_898852
Location (UCSC) Chr 13:
99.95 – 99.96 Mb
Chr 14:
121.95 – 121.97 Mb
PubMed search [1] [2]

G-protein coupled receptor 183 also known as Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) is a protein that in humans is encoded by the GPR183 gene.[1]

This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of the Burkitt's lymphoma cell line BL41.[2] This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes.[1]

EBI2 helps B cell homing within a lymph node. EBI2 expression increases during B cell activation, after B cell receptor and CD40 stimulation; its expression decreases during germinal cell development due to BCL6--a transcription factor required in germinal center development. EBI2 must turn on to move B cells to the germinal center from the periphery, and must turn off for B cells to exit the germinal center and re-enter the periphery.[3] EBI2 is a receptor for oxysterols, the most potent activator being 7α,25-dihydroxycholesterol.[4]

References[edit]

  1. ^ a b "Entrez Gene: EBI2 Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)". 
  2. ^ Birkenbach M, Josefsen K, Yalamanchili R, Lenoir G, Kieff E (Apr 1993). "Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors". J Virol 67 (4): 2209–20. PMC 240341. PMID 8383238. 
  3. ^ Pereira JP, Kelly LM, Xu Y, Cyster JG (Aug 2009). "EBI2 mediates B cell segregation between the outer and centre follicle". Nature 460 (7259): 1122–6. doi:10.1038/nature08226. PMID 19597478. 
  4. ^ Liu C, Yang X, Wu J,Kuei C, Mani N, Zhang L, Yu J, Sutton S, Qin N, Banie H, Karlsson L, Sun S, Lovenberg T (Jul 2011). "Oxysterols direct immune cell migration via EBI2". Nature 475 (7357): 519–23. doi:10.1038/nature10226. PMID 2179621. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.