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G protein-coupled receptor 183
Symbols GPR183 ; EBI2
External IDs OMIM605741 MGI2442034 HomoloGene28066 IUPHAR: GPR183 GeneCards: GPR183 Gene
RNA expression pattern
PBB GE EBI2 205419 at tn.png
More reference expression data
Species Human Mouse
Entrez 1880 321019
Ensembl ENSG00000169508 ENSMUSG00000051212
UniProt P32249 Q3U6B2
RefSeq (mRNA) NM_004951 NM_183031
RefSeq (protein) NP_004942 NP_898852
Location (UCSC) Chr 13:
99.95 – 99.96 Mb
Chr 14:
121.95 – 121.97 Mb
PubMed search [1] [2]

G-protein coupled receptor 183 also known as Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) is a protein that in humans is encoded by the GPR183 gene.[1]

This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of the Burkitt's lymphoma cell line BL41.[2] This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes.[1]

EBI2 helps B cell homing within a lymph node. EBI2 expression increases during B cell activation, after B cell receptor and CD40 stimulation; its expression decreases during germinal cell development due to BCL6--a transcription factor required in germinal center development. EBI2 must turn on to move B cells to the germinal center from the periphery, and must turn off for B cells to exit the germinal center and re-enter the periphery.[3] EBI2 is a receptor for oxysterols, the most potent activator being 7α,25-dihydroxycholesterol.[4]


  1. ^ a b "Entrez Gene: EBI2 Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)". 
  2. ^ Birkenbach M, Josefsen K, Yalamanchili R, Lenoir G, Kieff E (Apr 1993). "Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors". J Virol 67 (4): 2209–20. PMC 240341. PMID 8383238. 
  3. ^ Pereira JP, Kelly LM, Xu Y, Cyster JG (Aug 2009). "EBI2 mediates B cell segregation between the outer and centre follicle". Nature 460 (7259): 1122–6. doi:10.1038/nature08226. PMID 19597478. 
  4. ^ Liu C, Yang X, Wu J,Kuei C, Mani N, Zhang L, Yu J, Sutton S, Qin N, Banie H, Karlsson L, Sun S, Lovenberg T (Jul 2011). "Oxysterols direct immune cell migration via EBI2". Nature 475 (7357): 519–23. doi:10.1038/nature10226. PMID 2179621. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.