GABBR1

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Gamma-aminobutyric acid (GABA) B receptor, 1
Protein GABBR1 PDB 1srz.png
PDB rendering based on 1srz.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GABBR1 ; GABABR1; GABBR1-3; GB1; GPRC3A; dJ271M21.1.1; dJ271M21.1.2
External IDs OMIM603540 MGI1860139 HomoloGene1132 IUPHAR: GABAB1 ChEMBL: 2064 GeneCards: GABBR1 Gene
RNA expression pattern
PBB GE GABBR1 205890 s at tn.png
PBB GE GABBR1 203146 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2550 54393
Ensembl ENSG00000204681 ENSMUSG00000024462
UniProt Q9UBS5 Q9WV18
RefSeq (mRNA) NM_001470 NM_019439
RefSeq (protein) NP_001461 NP_062312
Location (UCSC) Chr 6:
29.52 – 29.6 Mb
Chr 17:
37.05 – 37.08 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid (GABA) B receptor, 1 (GABAB1), is a G-protein coupled receptor subunit encoded by the GABBR1 gene.

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.[1]

Interactions[edit]

GABBR1 has been shown to interact with ATF4[2] and GABBR2.[3]

See also[edit]

References[edit]

  1. ^ "Entrez Gene: GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1". 
  2. ^ White, J H; McIllhinney R A; Wise A; Ciruela F; Chan W Y; Emson P C; Billinton A; Marshall F H (December 2000). "The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (25): 13967–72. doi:10.1073/pnas.240452197. ISSN 0027-8424. PMC 17684. PMID 11087824. 
  3. ^ White, J H; Wise A; Main M J; Green A; Fraser N J; Disney G H; Barnes A A; Emson P; Foord S M; Marshall F H (December 1998). "Heterodimerization is required for the formation of a functional GABA(B) receptor". Nature (ENGLAND) 396 (6712): 679–82. doi:10.1038/25354. ISSN 0028-0836. PMID 9872316. 

External links[edit]

  • "GABAB Receptors: GABAB1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.