TAS2R14

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Taste receptor, type 2, member 14
Identifiers
Symbols TAS2R14 ; T2R14; TRB1
External IDs OMIM604790 MGI2681298 HomoloGene87013 IUPHAR: TAS2R14 GeneCards: TAS2R14 Gene
Orthologs
Species Human Mouse
Entrez 50840 387616
Ensembl ENSG00000212127 ENSMUSG00000071147
UniProt Q9NYV8 Q7TQA4
RefSeq (mRNA) NM_023922 NM_021562
RefSeq (protein) NP_076411 NP_067537
Location (UCSC) Chr 12:
11.09 – 11.32 Mb
Chr 6:
133.05 – 133.06 Mb
PubMed search [1] [2]

Taste receptor type 2 member 14 is a protein that in humans is encoded by the TAS2R14 gene.[1][2][3]

Function[edit]

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, TAS2R14 responds to (-)-α-thujone, the primary neurotoxic agent in absinthe, and picrotoxin, a poison found in fishberries.[4] This gene maps to the taste receptor gene cluster on chromosome 12p13.[3]

TAS2R14 is also expressed in the smooth muscle of human airways, along with several other bitter taste receptors. Their activation in these cells causes an increase in intracellular calcium ion, which in turn triggers the opening of potassium channels which hyperpolarize the membrane and cause the smooth muscle to relax. Hence, activation of these receptors leads to bronchodilation.[5]

See also[edit]

References[edit]

  1. ^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934. 
  2. ^ Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature 404 (6778): 601–4. doi:10.1038/35007072. PMID 10766242. 
  3. ^ a b "Entrez Gene: TAS2R14 taste receptor, type 2, member 14". 
  4. ^ Behrens M, Brockhoff A, Kuhn C, Bufe B, Winnig M, Meyerhof W (June 2004). "The human taste receptor hTAS2R14 responds to a variety of different bitter compounds". Biochem. Biophys. Res. Commun. 319 (2): 479–85. doi:10.1016/j.bbrc.2004.05.019. PMID 15178431. 
  5. ^ Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB (November 2010). "Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction". Nat. Med. 16 (11): 1299–304. doi:10.1038/nm.2237. PMC 3066567. PMID 20972434. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.