Glucagon-like peptide 2 receptor

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Glucagon-like peptide 2 receptor
Symbol GLP2R
External IDs OMIM603659 MGI2136733 HomoloGene3132 IUPHAR: GLP-2 receptor ChEMBL: 5844 GeneCards: GLP2R Gene
RNA expression pattern
PBB GE GLP2R 221312 at tn.png
More reference expression data
Species Human Mouse
Entrez 9340 93896
Ensembl ENSG00000065325 ENSMUSG00000049928
UniProt O95838 Q5IXF8
RefSeq (mRNA) NM_004246 NM_175681
RefSeq (protein) NP_004237 NP_783612
Location (UCSC) Chr 17:
9.73 – 9.8 Mb
Chr 11:
67.66 – 67.77 Mb
PubMed search [1] [2]

Glucagon-like peptide 2 receptor (GLP-2R) is a protein that in human is encoded by the GLP2R gene located on chromosome 17.[1]


The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor (GLP1 receptor). Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R).[2]

See also[edit]


  1. ^ Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels 8 (3–4): 179–88. doi:10.1080/10606820213687. PMID 12529935. 
  2. ^ "Entrez Gene: Glucagon-like peptide 2 receptor". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.