Methuselah-like proteins
| Methuselah N-terminus | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 Structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan.[1] | |||||||||||
| Identifiers | |||||||||||
| Symbol | Methuselah_N | ||||||||||
| Pfam | PF06652 | ||||||||||
| InterPro | IPR010596 | ||||||||||
| SCOP2 | 1fjr / SCOPe / SUPFAM | ||||||||||
| |||||||||||
The Methuselah-like proteins are a family of G protein-coupled receptors found in insects that play a role in aging and reproduction. Antagonizing these receptors can extend the life span of the animal and make it more resistant to free radicals and starvation, but also reduce reproduction and increase cold sensitivity. The age dependent decline in olfaction and motor function is unaffected.[2]
Methuselah-like proteins are related to G protein-coupled receptors of the secretin receptor family.[1]
References
- ^ a b West AP, Llamas LL, Snow PM, Benzer S, Bjorkman PJ (March 2001). "Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan". Proc. Natl. Acad. Sci. U.S.A. 98 (7): 3744–9. doi:10.1073/pnas.051625298. PMC 31123. PMID 11274391.
{{cite journal}}: CS1 maint: multiple names: authors list (link) Cite error: The named reference "pmid11274391" was defined multiple times with different content (see the help page). - ^ Alic N, Partridge L (2007). "Antagonizing Methuselah to extend life span". Genome Biology. 8 (8): 222. doi:10.1186/gb-2007-8-8-222. PMC 2374980. PMID 17764591.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
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