Platelet-activating factor receptor: Difference between revisions

PTAFR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B0X
Identifiers
Aliases	PTAFR, PAFR, platelet activating factor receptor
External IDs	OMIM: 173393; MGI: 106066; HomoloGene: 20260; GeneCards: PTAFR; OMA:PTAFR - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	28,193,936 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	132,309,994 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; bone marrow; ; vena cava; ; nasal epithelium; ; pericardium; ; cecum; ; body of tongue; ; bone marrow cells;
	Top expressed in
	granulocyte; ; bone marrow; ; white adipose tissue; ; jejunum; ; esophagus; ; ileum; ; spleen; ; zone of skin; ; urinary bladder; ; muscle of thigh;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; G protein-coupled purinergic nucleotide receptor activity; lipopolysaccharide binding; signal transducer activity; mitogen-activated protein kinase binding; platelet activating factor receptor activity; phospholipid binding; lipopolysaccharide immune receptor activity; protein binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; plasma membrane; secretory granule membrane; tertiary granule membrane;
Biological process	G protein-coupled receptor signaling pathway; positive regulation of leukocyte tethering or rolling; inositol trisphosphate biosynthetic process; positive regulation of voltage-gated chloride channel activity; positive regulation of phospholipase C activity; negative regulation of blood pressure; interferon-gamma-mediated signaling pathway; positive regulation of inositol phosphate biosynthetic process; regulation of transcription by RNA polymerase II; positive regulation of transcytosis; cytokine production; response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine; response to symbiotic bacterium; transcytosis; positive regulation of translation; cellular response to gravity; response to dexamethasone; positive regulation of cellular extravasation; positive regulation of maternal process involved in parturition; chemotaxis; cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine; positive regulation of sensory perception of pain; response to lipopolysaccharide; cellular response to fatty acid; response to organophosphorus; birth; positive regulation of vasoconstriction; immune response; positive regulation of gastro-intestinal system smooth muscle contraction; positive regulation of tumor necrosis factor production; inflammatory response; positive regulation of smooth muscle contraction; positive regulation of neutrophil degranulation; positive regulation of leukocyte cell-cell adhesion; phosphatidylinositol-mediated signaling; lipopolysaccharide-mediated signaling pathway; cellular response to cAMP; signal transduction; positive regulation of smooth muscle cell proliferation; G protein-coupled purinergic nucleotide receptor signaling pathway; neutrophil degranulation; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5724
	19204
	ENSG00000169403
	ENSMUSG00000056529
	P25105
	Q62035
	NM_001164723; NM_000952; NM_001164721; NM_001164722
	NM_001081211
	NP_000943; NP_001158193; NP_001158194; NP_001158195
	NP_001074680
	Wikidata
View/Edit Human	View/Edit Mouse

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The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169403 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056529 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Seyfried CE, Schweickart VL, Godiska R, Gray PW (1992). "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1". Genomics. 13 (3): 832–4. doi:10.1016/0888-7543(92)90162-L. PMID 1322356.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Ishii S, Nagase T, Shimizu T (2002). "Platelet-activating factor receptor". Prostaglandins Other Lipid Mediat. 68–69: 599–609. doi:10.1016/S0090-6980(02)00058-8. PMID 12432946.{{cite journal}}: CS1 maint: multiple names: authors list (link)

External links

IUPHAR GPCR Database - Platelet-activating factor receptor
platelet+activating+factor+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169403 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056529 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1322356-5] Seyfried CE, Schweickart VL, Godiska R, Gray PW (1992). "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1". Genomics. 13 (3): 832–4. doi:10.1016/0888-7543(92)90162-L. PMID 1322356.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid12432946-6] Ishii S, Nagase T, Shimizu T (2002). "Platelet-activating factor receptor". Prostaglandins Other Lipid Mediat. 68–69: 599–609. doi:10.1016/S0090-6980(02)00058-8. PMID 12432946.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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@@ Line 1: / Line 1: @@
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
-{{protein
+{{PBB_Controls
-| Name = platelet-activating factor receptor
-| caption =
+| update_page = yes
+| require_manual_inspection = no
-| image =
+| update_protein_box = yes
-| width =
-| HGNCid = 9582
+| update_summary = yes
+| update_citations = yes
-| Symbol = PTAFR
+}}
-| AltSymbols =
-| EntrezGene = 5724
+<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-| OMIM = 173393
+{{GNF_Protein_box
-| RefSeq = NM_000952
-| UniProt = P25105
+ | image =
-| PDB =
+ | image_source =
-| ECnumber =
+ | PDB =
+ | Name = Platelet-activating factor receptor
-| Chromosome = 1
-| Arm = p35
+ | HGNCid = 9582
-| Band = -p34.3
+ | Symbol = PTAFR
+ | AltSymbols =; PAFR
-| LocusSupplementaryData =
+ | OMIM = 173393
+ | ECnumber =
+ | Homologene = 20260
+ | MGIid = 106066
+ | GeneAtlas_image1 = PBB_GE_PTAFR_206278_at_tn.png
+ | GeneAtlas_image2 = PBB_GE_PTAFR_211661_x_at_tn.png
+ | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004992 |text = platelet activating factor receptor activity}} {{GNF_GO|id=GO:0005543 |text = phospholipid binding}}
+ | Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
+ | Process = {{GNF_GO|id=GO:0001816 |text = cytokine production}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}} {{GNF_GO|id=GO:0048015 |text = phosphoinositide-mediated signaling}}
+ | Orthologs = {{GNF_Ortholog_box
+    | Hs_EntrezGene = 5724
+    | Hs_Ensembl = ENSG00000169403
+    | Hs_RefseqProtein = NP_000943
+    | Hs_RefseqmRNA = NM_000952
+    | Hs_GenLoc_db =
+    | Hs_GenLoc_chr = 1
+    | Hs_GenLoc_start = 28346264
+    | Hs_GenLoc_end = 28392971
+    | Hs_Uniprot = P25105
+    | Mm_EntrezGene = 19204
+    | Mm_Ensembl = ENSMUSG00000056529
+    | Mm_RefseqmRNA = XM_357441
+    | Mm_RefseqProtein = XP_357441
+    | Mm_GenLoc_db =
+    | Mm_GenLoc_chr = 4
+    | Mm_GenLoc_start = 131836299
+    | Mm_GenLoc_end = 131852935
+    | Mm_Uniprot = Q62035
+  }}
 }}
 The [[platelet-activating factor receptor]] is a [[G-protein coupled receptor]] which binds [[platelet-activating factor]].<ref name="pmid1322356">{{cite journal | author = Seyfried CE, Schweickart VL, Godiska R, Gray PW | title = The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1 | journal = Genomics | volume = 13 | issue = 3 | pages = 832-4 | year = 1992 | pmid = 1322356 | doi = 10.1016/0888-7543(92)90162-L | issn = }}</ref><ref name="pmid12432946">{{cite journal | author = Ishii S, Nagase T, Shimizu T | title = Platelet-activating factor receptor | journal = Prostaglandins Other Lipid Mediat. | volume = 68-69 | issue = | pages = 599-609 | year = 2002 | pmid = 12432946 | doi = 10.1016/S0090-6980(02)00058-8 | issn = }}</ref>
+<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+{{PBB_Summary
+| section_title =
+| summary_text = PTAFR shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PTAFR platelet-activating factor receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5724| accessdate = }}</ref>
+}}
 ==References==
 <references/>
+==Further reading==
+{{refbegin | 2}}
+{{PBB_Further_reading
+| citations =
+*{{cite journal  | author=Shukla SD |title=Platelet-activating factor receptor and signal transduction mechanisms. |journal=FASEB J. |volume=6 |issue= 6 |pages= 2296-301 |year= 1992 |pmid= 1312046 |doi=  }}
+*{{cite journal  | author=Sugimoto T, Tsuchimochi H, McGregor CG, ''et al.'' |title=Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart. |journal=Biochem. Biophys. Res. Commun. |volume=189 |issue= 2 |pages= 617-24 |year= 1993 |pmid= 1281995 |doi=  }}
+*{{cite journal  | author=Seyfried CE, Schweickart VL, Godiska R, Gray PW |title=The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1. |journal=Genomics |volume=13 |issue= 3 |pages= 832-4 |year= 1992 |pmid= 1322356 |doi=  }}
+*{{cite journal  | author=Kunz D, Gerard NP, Gerard C |title=The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog. |journal=J. Biol. Chem. |volume=267 |issue= 13 |pages= 9101-6 |year= 1992 |pmid= 1374385 |doi=  }}
+*{{cite journal  | author=Ye RD, Prossnitz ER, Zou AH, Cochrane CG |title=Characterization of a human cDNA that encodes a functional receptor for platelet activating factor. |journal=Biochem. Biophys. Res. Commun. |volume=180 |issue= 1 |pages= 105-11 |year= 1991 |pmid= 1656963 |doi=  }}
+*{{cite journal  | author=Nakamura M, Honda Z, Izumi T, ''et al.'' |title=Molecular cloning and expression of platelet-activating factor receptor from human leukocytes. |journal=J. Biol. Chem. |volume=266 |issue= 30 |pages= 20400-5 |year= 1991 |pmid= 1657923 |doi=  }}
+*{{cite journal  | author=Haslam RJ, Williams KA, Davidson MM |title=Receptor-effector coupling in platelets: roles of guanine nucleotides. |journal=Adv. Exp. Med. Biol. |volume=192 |issue=  |pages= 265-80 |year= 1986 |pmid= 3010668 |doi=  }}
+*{{cite journal  | author=Valone FH |title=Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine. |journal=Immunology |volume=52 |issue= 1 |pages= 169-74 |year= 1984 |pmid= 6325330 |doi=  }}
+*{{cite journal  | author=Cundell DR, Gerard NP, Gerard C, ''et al.'' |title=Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor. |journal=Nature |volume=377 |issue= 6548 |pages= 435-8 |year= 1995 |pmid= 7566121 |doi= 10.1038/377435a0 }}
+*{{cite journal  | author=Izumi T, Kishimoto S, Takano T, ''et al.'' |title=Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation. |journal=Biochem. J. |volume=305 ( Pt 3) |issue=  |pages= 829-35 |year= 1995 |pmid= 7848283 |doi=  }}
+*{{cite journal  | author=Bito H, Honda Z, Nakamura M, Shimizu T |title=Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA. |journal=Eur. J. Biochem. |volume=221 |issue= 1 |pages= 211-8 |year= 1994 |pmid= 8168510 |doi=  }}
+*{{cite journal  | author=Chase PB, Halonen M, Regan JW |title=Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region. |journal=Am. J. Respir. Cell Mol. Biol. |volume=8 |issue= 3 |pages= 240-4 |year= 1993 |pmid= 8383507 |doi=  }}
+*{{cite journal  | author=Mutoh H, Bito H, Minami M, ''et al.'' |title=Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor. |journal=FEBS Lett. |volume=322 |issue= 2 |pages= 129-34 |year= 1993 |pmid= 8387031 |doi=  }}
+*{{cite journal  | author=Nakamura M, Honda Z, Matsumoto T, ''et al.'' |title=Isolation and properties of platelet-activating factor receptor cDNAs. |journal=Journal of lipid mediators |volume=6 |issue= 1-3 |pages= 163-8 |year= 1993 |pmid= 8395240 |doi=  }}
+*{{cite journal  | author=Kishimoto S, Shimadzu W, Izumi T, ''et al.'' |title=Regulation by IL-5 of expression of functional platelet-activating factor receptors on human eosinophils. |journal=J. Immunol. |volume=157 |issue= 9 |pages= 4126-32 |year= 1996 |pmid= 8892648 |doi=  }}
+*{{cite journal  | author=Chase PB, Yang JM, Thompson FH, ''et al.'' |title=Regional mapping of the human platelet-activating factor receptor gene (PTAFR) to 1p35-->p34.3 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=72 |issue= 2-3 |pages= 205-7 |year= 1997 |pmid= 8978777 |doi=  }}
+*{{cite journal  | author=Le Gouill C, Parent JL, Rola-Pleszczynski M, Stanková J |title=Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor. |journal=FEBS Lett. |volume=402 |issue= 2-3 |pages= 203-8 |year= 1997 |pmid= 9037196 |doi=  }}
+*{{cite journal  | author=Ahmed A, Dearn S, Shams M, ''et al.'' |title=Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125. |journal=FASEB J. |volume=12 |issue= 10 |pages= 831-43 |year= 1998 |pmid= 9657523 |doi=  }}
+*{{cite journal  | author=Cargill M, Altshuler D, Ireland J, ''et al.'' |title=Characterization of single-nucleotide polymorphisms in coding regions of human genes. |journal=Nat. Genet. |volume=22 |issue= 3 |pages= 231-8 |year= 1999 |pmid= 10391209 |doi= 10.1038/10290 }}
+}}
+{{refend}}
 ==External links==
-*[http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1348 IUPHAR GPCR Database - Platelet-activating factor receptor]
+* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1348 IUPHAR GPCR Database - Platelet-activating factor receptor]
 * {{MeshName|platelet+activating+factor+receptor}}
 {{membrane-protein-stub}}
+{{NLM content}}
 {{G protein-coupled receptors}}
 [[Category:G protein coupled receptors]]