Prolactin-releasing peptide receptor: Difference between revisions

PRLHR
Identifiers
Aliases	PRLHR, GPR10, GR3, PrRPR, prolactin releasing hormone receptor
External IDs	OMIM: 600895; MGI: 2135956; HomoloGene: 3134; GeneCards: PRLHR; OMA:PRLHR - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	118,595,648 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	60,456,742 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; anterior pituitary; ; islet of Langerhans; ; hypothalamus; ; substantia nigra; ; prefrontal cortex; ; vagina; ; myometrium; ; smooth muscle tissue; ; ganglionic eminence;
	Top expressed in
	hypothalamus; ; cerebellum; ; cerebellar cortex; ; mesencephalon;
	More reference expression data
	n/a
Gene ontology
Molecular function	neuropeptide Y receptor activity; G protein-coupled receptor activity; protein binding; signal transducer activity; neuropeptide receptor activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; cilium;
Biological process	female pregnancy; G protein-coupled receptor signaling pathway; hormone metabolic process; feeding behavior; signal transduction; neuropeptide signaling pathway; chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	2834
	226278
	ENSG00000119973
	ENSMUSG00000045052
	P49683
	Q6VMN6
	NM_004248
	NM_201615
	NP_004239
	NP_963909
	Wikidata
View/Edit Human	View/Edit Mouse

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The prolactin-releasing hormone receptor (PRLHR) is a G-protein coupled receptor^[5] that binds the prolactin releasing hormone.^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119973 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045052 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marchese A, Heiber M, Nguyen T, Heng HH, Saldivia VR, Cheng R, Murphy PM, Tsui LC, Shi X, Gregor P (1995). "Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors". Genomics. 29 (2): 335–44. PMID 8666380.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Hinuma S, Habata Y, Fujii R, Kawamata Y, Hosoya M, Fukusumi S, Kitada C, Masuo Y, Asano T, Matsumoto H, Sekiguchi M, Kurokawa T, Nishimura O, Onda H, Fujino M (1998). "A prolactin-releasing peptide in the brain". Nature. 393 (6682): 272–6. doi:10.1038/30515. PMID 9607765.{{cite journal}}: CS1 maint: multiple names: authors list (link)

External links

IUPHAR GPCR Database - Prolactin-releasing peptide receptor
PRLHR+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119973 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045052 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8666380-5] Marchese A, Heiber M, Nguyen T, Heng HH, Saldivia VR, Cheng R, Murphy PM, Tsui LC, Shi X, Gregor P (1995). "Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors". Genomics. 29 (2): 335–44. PMID 8666380.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid9607765-6] Hinuma S, Habata Y, Fujii R, Kawamata Y, Hosoya M, Fukusumi S, Kitada C, Masuo Y, Asano T, Matsumoto H, Sekiguchi M, Kurokawa T, Nishimura O, Onda H, Fujino M (1998). "A prolactin-releasing peptide in the brain". Nature. 393 (6682): 272–6. doi:10.1038/30515. PMID 9607765.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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@@ Line 1: / Line 1: @@
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
-{{protein
+{{PBB_Controls
-| Name = prolactin-releasing hormone receptor
-| caption =
+| update_page = yes
+| require_manual_inspection = no
-| image =
+| update_protein_box = yes
-| width =
-| HGNCid = 4464
+| update_summary = yes
+| update_citations = yes
-| Symbol = PRLHR
+}}
-| AltSymbols = GPR10
-| EntrezGene = 2834
+<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-| OMIM = 600895
+{{GNF_Protein_box
-| RefSeq = NM_004248
-| UniProt = P49683
+ | image =
-| PDB =
+ | image_source =
-| ECnumber =
+ | PDB =
+ | Name = Prolactin releasing hormone receptor
-| Chromosome = 10
-| Arm = q
+ | HGNCid = 4464
-| Band = 25.3
+ | Symbol = PRLHR
+ | AltSymbols =; GPR10; GR3; MGC126539; MGC126541; PrRPR
-| LocusSupplementaryData = -q26
+ | OMIM = 600895
+ | ECnumber =
+ | Homologene = 3134
+ | MGIid = 2135956
+ | Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004983 |text = neuropeptide Y receptor activity}}
+ | Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
+ | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0007631 |text = feeding behavior}} {{GNF_GO|id=GO:0042445 |text = hormone metabolic process}}
+ | Orthologs = {{GNF_Ortholog_box
+    | Hs_EntrezGene = 2834
+    | Hs_Ensembl = ENSG00000119973
+    | Hs_RefseqProtein = NP_004239
+    | Hs_RefseqmRNA = NM_004248
+    | Hs_GenLoc_db =
+    | Hs_GenLoc_chr = 10
+    | Hs_GenLoc_start = 120342951
+    | Hs_GenLoc_end = 120344746
+    | Hs_Uniprot = P49683
+    | Mm_EntrezGene = 226278
+    | Mm_Ensembl = ENSMUSG00000045052
+    | Mm_RefseqmRNA = NM_201615
+    | Mm_RefseqProtein = NP_963909
+    | Mm_GenLoc_db =
+    | Mm_GenLoc_chr = 19
+    | Mm_GenLoc_start = 60521677
+    | Mm_GenLoc_end = 60522789
+    | Mm_Uniprot = Q059H6
+  }}
 }}
 The '''prolactin-releasing hormone receptor''' ('''PRLHR''') is a [[G-protein coupled receptor]]<ref name="pmid8666380">{{cite journal | author = Marchese A, Heiber M, Nguyen T, Heng HH, Saldivia VR, Cheng R, Murphy PM, Tsui LC, Shi X, Gregor P | title = Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors | journal = Genomics | volume = 29 | issue = 2 | pages = 335–44 | year = 1995 | pmid = 8666380 | doi = | issn = }}</ref> that binds the [[prolactin]] [[releasing hormone]].<ref name="pmid9607765">{{cite journal | author = Hinuma S, Habata Y, Fujii R, Kawamata Y, Hosoya M, Fukusumi S, Kitada C, Masuo Y, Asano T, Matsumoto H, Sekiguchi M, Kurokawa T, Nishimura O, Onda H, Fujino M | title = A prolactin-releasing peptide in the brain | journal = Nature | volume = 393 | issue = 6682 | pages = 272-6 | year = 1998 | pmid = 9607765 | doi = 10.1038/30515 | issn = }}</ref>
+<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+{{PBB_Summary
+| section_title =
+| summary_text = PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PRLHR prolactin releasing hormone receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2834| accessdate = }}</ref>
+}}
 ==References==
 {{Reflist|2}}
+==Further reading==
+{{refbegin | 2}}
+{{PBB_Further_reading
+| citations =
+*{{cite journal  | author=Hinuma S, Onda H, Fujino M |title=The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors. |journal=J. Mol. Med. |volume=77 |issue= 6 |pages= 495-504 |year= 1999 |pmid= 10475064 |doi=  }}
+*{{cite journal  | author=Marchese A, Heiber M, Nguyen T, ''et al.'' |title=Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. |journal=Genomics |volume=29 |issue= 2 |pages= 335-44 |year= 1996 |pmid= 8666380 |doi=  }}
+*{{cite journal  | author=Hinuma S, Habata Y, Fujii R, ''et al.'' |title=A prolactin-releasing peptide in the brain. |journal=Nature |volume=393 |issue= 6682 |pages= 272-6 |year= 1998 |pmid= 9607765 |doi= 10.1038/30515 }}
+*{{cite journal  | author=Fujii R, Fukusumi S, Hosoya M, ''et al.'' |title=Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor. |journal=Regul. Pept. |volume=83 |issue= 1 |pages= 1-10 |year= 1999 |pmid= 10498338 |doi=  }}
+*{{cite journal  | author=Langmead CJ, Szekeres PG, Chambers JK, ''et al.'' |title=Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor. |journal=Br. J. Pharmacol. |volume=131 |issue= 4 |pages= 683-8 |year= 2000 |pmid= 11030716 |doi= 10.1038/sj.bjp.0703617 }}
+*{{cite journal  | author=Lin SH, Arai AC, Wang Z, ''et al.'' |title=The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering. |journal=Mol. Pharmacol. |volume=60 |issue= 5 |pages= 916-23 |year= 2001 |pmid= 11641419 |doi=  }}
+*{{cite journal  | author=Ozawa A, Yamada M, Satoh T, ''et al.'' |title=Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 Receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region. |journal=Mol. Endocrinol. |volume=16 |issue= 4 |pages= 785-98 |year= 2002 |pmid= 11923475 |doi=  }}
+*{{cite journal  | author=Takahashi K, Totsune K, Murakami O, ''et al.'' |title=Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas. |journal=Peptides |volume=23 |issue= 6 |pages= 1135-40 |year= 2003 |pmid= 12126742 |doi=  }}
+*{{cite journal  | author=Kemp DM, Lin JC, Ubeda M, Habener JF |title=NRSF/REST confers transcriptional repression of the GPR10 gene via a putative NRSE/RE-1 located in the 5' promoter region. |journal=FEBS Lett. |volume=531 |issue= 2 |pages= 193-8 |year= 2002 |pmid= 12417311 |doi=  }}
+*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | author=Bhattacharyya S, Luan J, Challis B, ''et al.'' |title=Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population. |journal=Diabetes |volume=52 |issue= 5 |pages= 1296-9 |year= 2003 |pmid= 12716769 |doi=  }}
+*{{cite journal  | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
+*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  | author=Ellacott KL, Donald EL, Clarkson P, ''et al.'' |title=Characterization of a naturally-occurring polymorphism in the UHR-1 gene encoding the putative rat prolactin-releasing peptide receptor. |journal=Peptides |volume=26 |issue= 4 |pages= 675-81 |year= 2005 |pmid= 15752583 |doi= 10.1016/j.peptides.2004.11.020 }}
+*{{cite journal  | author=Lagerström MC, Fredriksson R, Bjarnadóttir TK, ''et al.'' |title=Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution. |journal=Genomics |volume=85 |issue= 6 |pages= 688-703 |year= 2005 |pmid= 15885496 |doi= 10.1016/j.ygeno.2005.02.007 }}
+*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
+}}
+{{refend}}
 ==External links==
@@ Line 29: / Line 85: @@
 {{membrane-protein-stub}}
+{{NLM content}}
 {{G protein-coupled receptors}}
 [[Category:G protein coupled receptors]]