Methuselah-like proteins: Difference between revisions
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| ⚫ | The Methuselah-like proteins are [[G protein-coupled receptor]]s found in insects |
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| Symbol = Methuselah_N |
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| Name = Methuselah N-terminus |
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| Pfam = PF06652 |
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| InterPro = IPR010596 |
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| SMART = |
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| PROSITE = |
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| SCOP = 1fjr |
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| OPM family = |
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| OPM protein = |
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| PDB = {{PDB2|1fjr}} |
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| ⚫ | The Methuselah-like proteins are a family of [[G protein-coupled receptor]]s found in insects that play a role in aging and reproduction. [[Receptor antagonist|Antagonizing]] these receptors can extend the life span of the animal and make it more resistant to free radicals and starvation, but also reduce reproduction and increase cold sensitivity. The age dependent decline in olfaction and motor function is unaffected.<ref name="pmid17764591">{{cite journal | author = Alic N, Partridge L | title = Antagonizing Methuselah to extend life span | journal = Genome Biology | volume = 8 | issue = 8 | pages = 222 | year = 2007 | pmid = 17764591 | pmc = 2374980 | doi = 10.1186/gb-2007-8-8-222 | url = | issn = }}</ref> |
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Methuselah-like proteins are related to G protein-coupled receptors of the [[secretin receptor]] family.<ref name="pmid11274391">{{cite journal | author = West AP, Llamas LL, Snow PM, Benzer S, Bjorkman PJ | title = Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 7 | pages = 3744–9 | year = 2001 | month = March | pmid = 11274391 | pmc = 31123 | doi = 10.1073/pnas.051625298 | url = | issn = }}</ref> |
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== References == |
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{{Reflist}} |
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Nazif Alic and Linda Partridge: Antagonizing Methuselah to extend life span, Genome Biol. 2007; 8(8): 222.{{PMID|17764591}} |
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{{protein-stub}} |
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{{G protein-coupled receptors}} |
{{G protein-coupled receptors}} |
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[[Category:G protein coupled receptors]] |
[[Category:G protein coupled receptors]] |
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Revision as of 21:23, 5 May 2009
| Methuselah N-terminus | |||||||||||
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| Identifiers | |||||||||||
| Symbol | Methuselah_N | ||||||||||
| Pfam | PF06652 | ||||||||||
| InterPro | IPR010596 | ||||||||||
| SCOP2 | 1fjr / SCOPe / SUPFAM | ||||||||||
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The Methuselah-like proteins are a family of G protein-coupled receptors found in insects that play a role in aging and reproduction. Antagonizing these receptors can extend the life span of the animal and make it more resistant to free radicals and starvation, but also reduce reproduction and increase cold sensitivity. The age dependent decline in olfaction and motor function is unaffected.[1]
Methuselah-like proteins are related to G protein-coupled receptors of the secretin receptor family.[2]
References
- ^ Alic N, Partridge L (2007). "Antagonizing Methuselah to extend life span". Genome Biology. 8 (8): 222. doi:10.1186/gb-2007-8-8-222. PMC 2374980. PMID 17764591.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ West AP, Llamas LL, Snow PM, Benzer S, Bjorkman PJ (2001). "Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan". Proceedings of the National Academy of Sciences of the United States of America. 98 (7): 3744–9. doi:10.1073/pnas.051625298. PMC 31123. PMID 11274391.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)
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