Alpha-1B adrenergic receptor

ADRA1B
Identifiers
Aliases	ADRA1B, ADRA1, ALPHA1BAR, adrenoceptor alpha 1B
External IDs	OMIM: 104220 MGI: 104774 HomoloGene: 55477 GeneCards: ADRA1B
Gene location (Human) Chr. Chromosome 5 (human) Band 5q33.3 Start 159,865,080 bp End 159,973,012 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B1.1|11 25.81 cM Start 43,665,433 bp End 43,792,037 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver thoracic aorta ascending aorta popliteal artery prefrontal cortex cingulate gyrus right lung spleen Brodmann area 9 left uterine tube Top expressed in left lobe of liver superior frontal gyrus right ventricle lateral geniculate nucleus medial dorsal nucleus cardiac muscles cerebellar cortex calvaria neural tube primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity adrenergic receptor activity protein heterodimerization activity alpha1-adrenergic receptor activity protein binding Cellular component integral component of membrane membrane integral component of plasma membrane nucleus nuclear membrane plasma membrane cytoplasm caveola Biological process regulation of muscle contraction intracellular signal transduction norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure glucose homeostasis adenylate cyclase-modulating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling multicellular organism development adenylate cyclase-activating adrenergic receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway regulation of vasoconstriction positive regulation of vasoconstriction regulation of cardiac muscle contraction cell population proliferation positive regulation of smooth muscle contraction positive regulation of MAPK cascade signal transduction G protein-coupled receptor signaling pathway neuron-glial cell signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 147 11548 Ensembl ENSG00000170214 ENSMUSG00000050541 UniProt P35368 P97717 RefSeq (mRNA) NM_000679 NM_001284380 NM_001284381 NM_007416 RefSeq (protein) NP_000670 n/a Location (UCSC) Chr 5: 159.87 – 159.97 Mb Chr 11: 43.67 – 43.79 Mb PubMed search
Wikidata
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The alpha-1B adrenergic receptor (α_1B adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.

Receptor

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

Gene

This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.

Ligands

Antagonists

• L-765,314
• Risperidone

Interactions

Alpha-1B adrenergic receptor has been shown to interact with AP2M1. A role in regulation of dopaminergic neurotransmission has also been suggested.

See also

• Adrenergic receptor

Further reading

• Ramarao CS, Denker JM, Perez DM; et al. (1992). "Genomic organization and expression of the human alpha 1B-adrenergic receptor". J. Biol. Chem. 267 (30): 21936–45. PMID 1328250.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Allen LF, Lefkowitz RJ, Caron MG, Cotecchia S (1992). "G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11354–8. doi:10.1073/pnas.88.24.11354. PMC 53133. PMID 1662393.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Lomasney JW, Cotecchia S, Lorenz W; et al. (1991). "Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5". J. Biol. Chem. 266 (10): 6365–9. PMID 1706716.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Yang-Feng TL, Xue FY, Zhong WW; et al. (1990). "Chromosomal organization of adrenergic receptor genes". Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1516–20. doi:10.1073/pnas.87.4.1516. PMC 53506. PMID 2154750.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Schwinn DA, Johnston GI, Page SO; et al. (1995). "Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues". J. Pharmacol. Exp. Ther. 272 (1): 134–42. PMID 7815325.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Weinberg DH, Trivedi P, Tan CP; et al. (1994). "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c". Biochem. Biophys. Res. Commun. 201 (3): 1296–304. doi:10.1006/bbrc.1994.1845. PMID 8024574.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Forray C, Bard JA, Wetzel JM; et al. (1994). "The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype". Mol. Pharmacol. 45 (4): 703–8. PMID 8183249.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Diviani D, Lattion AL, Larbi N; et al. (1996). "Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor". J. Biol. Chem. 271 (9): 5049–58. doi:10.1074/jbc.271.9.5049. PMID 8617782.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
• Diviani D, Lattion AL, Cotecchia S (1997). "Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor". J. Biol. Chem. 272 (45): 28712–9. doi:10.1074/jbc.272.45.28712. PMID 9353340.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
• Qian A, Wang W, Sanborn BM (1998). "Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11)". Cell. Signal. 10 (2): 101–5. doi:10.1016/S0898-6568(97)00097-1. PMID 9481484.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Sasaguri T, Teruya H, Ishida A; et al. (2000). "Linkage between alpha(1) adrenergic receptor and the Jak/STAT signaling pathway in vascular smooth muscle cells". Biochem. Biophys. Res. Commun. 268 (1): 25–30. doi:10.1006/bbrc.1999.2066. PMID 10652206.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Minneman KP, Lee D, Zhong H; et al. (2000). "Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes". J. Neurochem. 74 (6): 2392–400. doi:10.1046/j.1471-4159.2000.0742392.x. PMID 10820200.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Shibata K, Katsuma S, Koshimizu T; et al. (2003). "alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1". J. Biol. Chem. 278 (1): 672–8. doi:10.1074/jbc.M201375200. PMID 12409310.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
• Diviani D, Lattion AL, Abuin L; et al. (2003). "The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis". J. Biol. Chem. 278 (21): 19331–40. doi:10.1074/jbc.M302110200. PMID 12644451.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
• Gonzalez-Cabrera PJ, Gaivin RJ, Yun J; et al. (2003). "Genetic profiling of alpha 1-adrenergic receptor subtypes by oligonucleotide microarrays: coupling to interleukin-6 secretion but differences in STAT3 phosphorylation and gp-130". Mol. Pharmacol. 63 (5): 1104–16. doi:10.1124/mol.63.5.1104. PMID 12695539.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Pupo AS, Minneman KP (2004). "Specific interactions between gC1qR and alpha1-adrenoceptor subtypes". J. Recept. Signal Transduct. Res. 23 (2–3): 185–95. doi:10.1081/RRS-120025200. PMID 14626446.
• Hague C, Uberti MA, Chen Z; et al. (2004). "Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors". J. Biol. Chem. 279 (15): 15541–9. doi:10.1074/jbc.M314014200. PMID 14736874.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
• Kang SK, Yi KS, Kwon NS; et al. (2004). "Alpha1B-adrenoceptor signaling and cell motility: GTPase function of Gh/transglutaminase 2 inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits". J. Biol. Chem. 279 (35): 36593–600. doi:10.1074/jbc.M402084200. PMID 15220331.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
• Gonzalez-Cabrera PJ, Shi T, Yun J; et al. (2004). "Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes". Endocrinology. 145 (11): 5157–67. doi:10.1210/en.2004-0728. PMID 15297446.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Zhang T, Xu Q, Chen FR; et al. (2005). "Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors". Acta Pharmacol. Sin. 25 (11): 1471–8. PMID 15525470.{{cite journal}}: CS1 maint: multiple names: authors list (link)