S1PR5

Sphingosine-1-phosphate receptor 5
Identifiers
Symbols	S1PR5; EDG8; Edg-8; S1P5; SPPR-1; SPPR-2
External IDs	OMIM: 605146 MGI: 2150641 HomoloGene: 11031 IUPHAR: S1P5 GeneCards: S1PR5 Gene
Gene Ontology Molecular function • lysosphingolipid and lysophosphatidic acid receptor activity • receptor activity • G-protein coupled receptor activity Cellular component • plasma membrane • plasma membrane • integral to membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	53637	94226
Ensembl	ENSG00000180739	ENSMUSG00000045087
UniProt	Q9H228	Q91X56
RefSeq (mRNA)	NM_001166215.1	NM_053190.2
RefSeq (protein)	NP_001159687.1	NP_444420.1
Location (UCSC)	Chr 19: 10.62 – 10.63 Mb	Chr 9: 21.05 – 21.05 Mb
PubMed search	[1]	[2]

Sphingosine-1-phosphate receptor 5 also known as S1PR5 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₅.

See also

• Lysophospholipid receptor

Further reading

• Im DS, Heise CE, Ancellin N, et al. (2000). "Characterization of a novel sphingosine 1-phosphate receptor, Edg-8.". J. Biol. Chem. 275 (19): 14281–6. doi:10.1074/jbc.275.19.14281. PMID 10799507. 
• Malek RL, Toman RE, Edsall LC, et al. (2001). "Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors.". J. Biol. Chem. 276 (8): 5692–9. doi:10.1074/jbc.M003964200. PMID 11069896. 
• Hla T. Sphingosine 1-phosphate receptors.. 64. pp. 135–142. PMID 11331101. 
• Im DS, Clemens J, Macdonald TL, Lynch KR (2001). "Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors.". Biochemistry 40 (46): 14053–60. doi:10.1021/bi011606i. PMID 11705398. 
• Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence.". FEBS Lett. 520 (1-3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. 
• Niedernberg A, Scherer CR, Busch AE, Kostenis E (2002). "Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists.". Biochem. Pharmacol. 64 (8): 1243–50. doi:10.1016/S0006-2952(02)01289-3. PMID 12234605. 
• Kothapalli R, Kusmartseva I, Loughran TP (2003). "Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia.". Biochim. Biophys. Acta 1579 (2-3): 117–23. PMID 12427546. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Vogler R, Sauer B, Kim DS, et al. (2003). "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing.". J. Invest. Dermatol. 120 (4): 693–700. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Ulfig N, Briese M (2005). "Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers.". Acta Histochem. 106 (5): 373–8. doi:10.1016/j.acthis.2004.08.002. PMID 15530552. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743. 

External links

• "Lysophospholipid Receptors: S₁P₅". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2997. 
• MeSH Lysophospholipid+receptors

This article incorporates text from the United States National Library of Medicine, which is in the public domain.