GPR37

GPR37
Identifiers
Aliases	GPR37, EDNRBL, PAELR, hET(B)R-LP, G protein-coupled receptor 37
External IDs	OMIM: 602583 MGI: 1313297 HomoloGene: 3875 GeneCards: GPR37
Gene location (Human)
Chr.	Chromosome 7 (human)
End	124,765,792 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	25,690,728 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; inferior ganglion of vagus nerve; ; optic nerve; ; middle frontal gyrus; ; subthalamic nucleus; ; medulla oblongata; ; ventral tegmental area; ; superior vestibular nucleus; ; external globus pallidus; ; inferior olivary nucleus;
	Top expressed in
	globus pallidus; ; lateral geniculate nucleus; ; utricle; ; pontine nuclei; ; medial geniculate nucleus; ; anterior horn of spinal cord; ; ventral tegmental area; ; dorsal tegmental nucleus; ; medial vestibular nucleus; ; lateral hypothalamus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled peptide receptor activity; G protein-coupled receptor activity; heat shock protein binding; prosaposin receptor activity; peptide binding; signal transducer activity; Hsp70 protein binding; protein binding; ubiquitin protein ligase binding;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; ubiquitin ligase complex; receptor complex; plasma membrane; integral component of plasma membrane; endoplasmic reticulum;
Biological process	G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; dopamine biosynthetic process; negative regulation of hydrogen peroxide-induced cell death; locomotion involved in locomotory behavior; positive regulation of MAPK cascade; signal transduction; positive regulation of dopamine metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2861
	14763
	ENSG00000170775
	ENSMUSG00000039904
	O15354
	Q9QY42
	NM_005302
	NM_010338
	NP_005293
	NP_034468
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 37 is a protein that in humans is encoded by the GPR37 gene.^[5]^[6]

Interactions

GPR37 has been shown to interact with HSPA1A^[7] and Parkin (ligase).^[7]^[8] GPR37 is a receptor for prosaposin. It was previously thought to be a receptor for head activator, a neuropeptide found in the hydra, but early reports of head activator in mammals were never confirmed.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170775 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039904 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP (November 1997). "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library". Genomics. 45 (1): 68–77. doi:10.1006/geno.1997.4900. PMID 9339362.
^ "Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)".
^ ^a ^b Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R (July 2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Mol. Cell. 10 (1): 55–67. doi:10.1016/S1097-2765(02)00583-X. PMID 12150907.
^ Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R (June 2001). "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin". Cell. 105 (7): 891–902. doi:10.1016/S0092-8674(01)00407-X. PMID 11439185.
^ Meyer, Rebecca C.; Giddens, Michelle M.; Schaefer, Stacy A.; Hall, Randy A. (4 June 2013). "GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin". Proceedings of the National Academy of Sciences. 110 (23): 9529–34. doi:10.1073/pnas.1219004110. PMID 23690594.

Zeng Z, Su K, Kyaw H, Li Y (1997). "A novel endothelin receptor type-B-like gene enriched in the brain". Biochem. Biophys. Res. Commun. 233 (2): 559–67. doi:10.1006/bbrc.1997.6408. PMID 9144577.
Donohue PJ, Shapira H, Mantey SA, Hampton LL, Jensen RT, Battey JF (1998). "A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system". Brain Res. Mol. Brain Res. 54 (1): 152–60. doi:10.1016/S0169-328X(97)00336-7. PMID 9526070.
Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R (2001). "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin". Cell. 105 (7): 891–902. doi:10.1016/S0092-8674(01)00407-X. PMID 11439185.
Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R (2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Mol. Cell. 10 (1): 55–67. doi:10.1016/S1097-2765(02)00583-X. PMID 12150907.
Yang Y, Nishimura I, Imai Y, Takahashi R, Lu B (2003). "Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila". Neuron. 37 (6): 911–24. doi:10.1016/S0896-6273(03)00143-0. PMID 12670421.
Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R (2003). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". J. Biol. Chem. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Kubota K, Niinuma Y, Kaneko M, Okuma Y, Sugai M, Omura T, Uesugi M, Uehara T, Hosoi T, Nomura Y (2006). "Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress". J. Neurochem. 97 (5): 1259–68. doi:10.1111/j.1471-4159.2006.03782.x. PMID 16539653.
Omura T, Kaneko M, Okuma Y, Orba Y, Nagashima K, Takahashi R, Fujitani N, Matsumura S, Hata A, Kubota K, Murahashi K, Uehara T, Nomura Y (2006). "A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin". J. Neurochem. 99 (6): 1456–69. doi:10.1111/j.1471-4159.2006.04155.x. PMID 17059562.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170775 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039904 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9339362-5] Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP (November 1997). "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library". Genomics. 45 (1): 68–77. doi:10.1006/geno.1997.4900. PMID 9339362.

[entrez-6] "Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)".

[pmid12150907-7] Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R (July 2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Mol. Cell. 10 (1): 55–67. doi:10.1016/S1097-2765(02)00583-X. PMID 12150907.

[pmid11439185-8] Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R (June 2001). "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin". Cell. 105 (7): 891–902. doi:10.1016/S0092-8674(01)00407-X. PMID 11439185.

[9] Meyer, Rebecca C.; Giddens, Michelle M.; Schaefer, Stacy A.; Hall, Randy A. (4 June 2013). "GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin". Proceedings of the National Academy of Sciences. 110 (23): 9529–34. doi:10.1073/pnas.1219004110. PMID 23690594.

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Interactions

References

Further reading