Latrophilin: Difference between revisions

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The '''latrophilin receptor'''s are a group of related [[G-protein coupled receptor]]s from the class B [[secretin receptor family| secretin family]]. These receptors were originally identified based on their ability to bind [[alpha-latrotoxin]].<ref name="pmid12196116">{{cite journal | author = Kreienkamp HJ, Soltau M, Richter D, Böckers T | title = Interaction of G-protein-coupled receptors with synaptic scaffolding proteins | journal = Biochem. Soc. Trans. | volume = 30 | issue = 4 | pages = 464–8 | year = 2002 | pmid = 12196116 | doi = 10.1042/BST0300464| url = http://www.biochemsoctrans.org/bst/030/bst0300464.htm}}</ref>
'''Latrophilins''' are a group of related [[G-protein coupled receptor]]s from the class B [[secretin receptor family| secretin family]]. These receptors were originally identified based on their ability to bind the spider venom [[alpha-latrotoxin]].<ref name="pmid12196116">{{cite journal | author = Kreienkamp HJ, Soltau M, Richter D, Böckers T | title = Interaction of G-protein-coupled receptors with synaptic scaffolding proteins | journal = Biochem. Soc. Trans. | volume = 30 | issue = 4 | pages = 464–8 | year = 2002 | pmid = 12196116 | doi = 10.1042/BST0300464| url = http://www.biochemsoctrans.org/bst/030/bst0300464.htm}}</ref> This conserved family of membrane proteins has up to three homologues in chordate species, including humans.<ref name="JPS">{{cite journal|last1=Silva|first1=JP|last2=Ushkaryov|first2=YA|title=The latrophilins, "split-personality" receptors.|journal=Advances in Experimental Medicine and biology|date=2010|volume=706|pages=59-75|pmid=21618826}}</ref>

The precise functions of latrophilins remain unknown.<ref name="JPS" />


==Human proteins containing this domain ==
==Human proteins containing this domain ==
*Latrophilin 1 ([[LPHN1]])
[[LPHN1]]; [[LPHN2]]; [[LPHN3]];
*Latrophilin 2 ([[LPHN2]])
*Latrophilin 3 ([[LPHN3]])


==References==
==References==

Revision as of 11:07, 22 February 2016

Latrophilin
Identifiers
SymbolLatrophilin
PfamPF02354
InterProIPR003334
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
EGF, latrophilin and seven transmembrane domain containing 1
Identifiers
SymbolELTD1
Alt. symbolsETL
NCBI gene64123
HGNC20822
RefSeqNM_022159
UniProtQ9HBW9
Other data
LocusChr. 1 p33-p32
Search for
StructuresSwiss-model
DomainsInterPro
latrophilin 1
Identifiers
SymbolLPHN1
Alt. symbolsKIAA0821, CIRL1, LEC2
NCBI gene22859
HGNC20973
RefSeqNM_014921
UniProtO94910
Other data
LocusChr. 19 p13.2
Search for
StructuresSwiss-model
DomainsInterPro
latrophilin 2
Identifiers
SymbolLPHN2
Alt. symbolsLPHH1, KIAA0786, LEC1
NCBI gene23266
HGNC18582
OMIM607018
RefSeqNM_012302
UniProtO95490
Other data
LocusChr. 1 p31.1
Search for
StructuresSwiss-model
DomainsInterPro
latrophilin 3
Identifiers
SymbolLPHN3
Alt. symbolsKIAA0768, LEC3
NCBI gene23284
HGNC20974
RefSeqNM_015236
UniProtQ9HAR2
Other data
LocusChr. 4 q13.1
Search for
StructuresSwiss-model
DomainsInterPro

Latrophilins are a group of related G-protein coupled receptors from the class B secretin family. These receptors were originally identified based on their ability to bind the spider venom alpha-latrotoxin.[1] This conserved family of membrane proteins has up to three homologues in chordate species, including humans.[2]

The precise functions of latrophilins remain unknown.[2]

Human proteins containing this domain

References

  1. ^ Kreienkamp HJ, Soltau M, Richter D, Böckers T (2002). "Interaction of G-protein-coupled receptors with synaptic scaffolding proteins". Biochem. Soc. Trans. 30 (4): 464–8. doi:10.1042/BST0300464. PMID 12196116.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ a b Silva, JP; Ushkaryov, YA (2010). "The latrophilins, "split-personality" receptors". Advances in Experimental Medicine and biology. 706: 59–75. PMID 21618826.
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