TRPC5

TRPC5
Identifiers
Aliases	TRPC5, PPP1R159, TRP5, transient receptor potential cation channel subfamily C member 5
External IDs	OMIM: 300334; MGI: 109524; HomoloGene: 74915; GeneCards: TRPC5; OMA:TRPC5 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	112,082,776 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	143,471,176 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; prefrontal cortex; ; gastric mucosa; ; ganglionic eminence; ; liver; ; Brodmann area 9; ; primary visual cortex; ; hypothalamus; ; right lobe of liver;
	Top expressed in
	supraoptic nucleus; ; lumbar subsegment of spinal cord; ; dentate gyrus of hippocampal formation granule cell; ; zygote; ; lateral hypothalamus; ; primary visual cortex; ; ventromedial nucleus; ; superior frontal gyrus; ; secondary oocyte; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	inositol 1,4,5 trisphosphate binding; ion channel activity; store-operated calcium channel activity; protein binding; calcium channel activity; clathrin binding; actin binding; actinin binding; ATPase binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; calcium channel complex; membrane; cytoplasm; growth cone; soma; dendrite; membrane raft; cation channel complex;
Biological process	manganese ion transport; ion transport; regulation of cytosolic calcium ion concentration; calcium ion transmembrane transport; calcium ion transport; nervous system development; regulation of membrane hyperpolarization; positive regulation of peptidyl-threonine phosphorylation; positive regulation of axon extension; positive regulation of cell population proliferation; positive regulation of cytosolic calcium ion concentration; neuron differentiation; positive regulation of neuron differentiation; negative regulation of dendrite morphogenesis; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	7224
	22067
	ENSG00000072315
	ENSMUSG00000041710
	Q9UL62
	Q9QX29
	NM_012471
	NM_009428
	NP_036603
	NP_033454
	Wikidata
View/Edit Human	View/Edit Mouse

Short transient receptor potential channel 5 (TrpC5) also known as transient receptor protein 5 (TRP-5) is a protein that in humans is encoded by the TRPC5 gene.^[5]^[6]^[7] TrpC5 is subtype of the TRPC family of mammalian transient receptor potential ion channels.

Function

TrpC5 is one of the seven mammalian TRPC (transient receptor potential canonical) proteins. TrpC5 is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na⁺–H⁺ exchange regulatory factor (NHERF), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1).^[5]

TRPC4 and TRPC5 have been implicated in the mechanism of mercury toxicity^[8] and neurological behavior.^[9] It was established in 2021 that TRPC5 is a component of the dental cold sensing system.^[10]

Activation

Homomultimeric TRPC5 and heteromultimeric TRPC5-TRPC1 channels are activated by extracellular reduced thioredoxin.^[11] This channel has also been found to be involved in the action of anaesthetics such as chloroform, halothane and propofol.^[12]

Interactions

TRPC5 has been shown to interact with STMN3,^[13] TRPC1,^[14]^[15] and TRPC4.^[15]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000072315 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041710 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: transient receptor potential cation channel".
^ Sossey-Alaoui K, Lyon JA, Jones L, Abidi FE, Hartung AJ, Hane B, Schwartz CE, Stevenson RE, Srivastava AK (September 1999). "Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel". Genomics. 60 (3): 330–40. doi:10.1006/geno.1999.5924. PMID 10493832.
^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
^ Xu SZ, Zeng B, Daskoulidou N, Chen GL, Atkin SL, Lukhele B (January 2012). "Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure". Toxicol. Sci. 125 (1): 56–68. doi:10.1093/toxsci/kfr268. PMID 21984481.
^ Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE (May 15, 2009). "Essential role for TRPC5 in amygdala function and fear-related behavior". Cell. 137 (4): 761–72. doi:10.1016/j.cell.2009.03.039. PMC 2719954. PMID 19450521.
^ Bernal, Laura; Sotelo-Hitschfeld, Pamela; König, Christine; Sinica, Viktor; Wyatt, Amanda; Winter, Zoltan; Hein, Alexander; Touska, Filip; Reinhardt, Susanne; Tragl, Aaron; Kusuda, Ricardo; Wartenberg, Philipp; Sclaroff, Allen; Pfeifer, John D.; Ectors, Fabien; Dahl, Andreas; Freichel, Marc; Vlachova, Viktorie; Brauchi, Sebastian; Roza, Carolina; Boehm, Ulrich; Clapham, David E.; Lennerz, Jochen K.; Zimmermann, Katharina (2021). "Odontoblast TRPC5 channels signal cold pain in teeth". Science Advances. 7 (13): eabf5567. doi:10.1126/sciadv.abf5567. PMC 7997515. PMID 33771873.
^ Xu SZ, Sukumar P, Zeng F, Li J, Jairaman A, English A, Naylor J, Ciurtin C, Majeed Y, Milligan CJ, Bahnasi YM, Al-Shawaf E, Porter KE, Jiang LH, Emery P, Sivaprasadarao A, Beech DJ (January 2008). "TRPC channel activation by extracellular thioredoxin". Nature. 451 (7174): 69–72. doi:10.1038/nature06414. PMC 2645077. PMID 18172497.
^ Bahnasi YM, Wright HM, Milligan CJ, Dedman AM, Zeng F, Hopkins PM, Bateson AN, Beech DJ (April 2008). "Modulation of TRPC5 cation channels by halothane, chloroform and propofol". Br. J. Pharmacol. 153 (7): 1505–12. doi:10.1038/sj.bjp.0707689. PMC 2437913. PMID 18204473.
^ Greka A, Navarro B, Oancea E, Duggan A, Clapham DE (August 2003). "TRPC5 is a regulator of hippocampal neurite length and growth cone morphology". Nat. Neurosci. 6 (8): 837–45. doi:10.1038/nn1092. PMID 12858178. S2CID 7523946.
^ Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE (October 2003). "Formation of novel TRPC channels by complex subunit interactions in embryonic brain". J. Biol. Chem. 278 (40): 39014–9. doi:10.1074/jbc.M306705200. PMID 12857742.
^ ^a ^b Hofmann T, Schaefer M, Schultz G, Gudermann T (May 2002). "Subunit composition of mammalian transient receptor potential channels in living cells". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7461–6. doi:10.1073/pnas.102596199. PMC 124253. PMID 12032305.

External links

TRPC5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000072315 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041710 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: transient receptor potential cation channel".

[pmid10493832-6] Sossey-Alaoui K, Lyon JA, Jones L, Abidi FE, Hartung AJ, Hane B, Schwartz CE, Stevenson RE, Srivastava AK (September 1999). "Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel". Genomics. 60 (3): 330–40. doi:10.1006/geno.1999.5924. PMID 10493832.

[pmid16382100-7] Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

[8] Xu SZ, Zeng B, Daskoulidou N, Chen GL, Atkin SL, Lukhele B (January 2012). "Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure". Toxicol. Sci. 125 (1): 56–68. doi:10.1093/toxsci/kfr268. PMID 21984481.

[9] Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE (May 15, 2009). "Essential role for TRPC5 in amygdala function and fear-related behavior". Cell. 137 (4): 761–72. doi:10.1016/j.cell.2009.03.039. PMC 2719954. PMID 19450521.

[10] Bernal, Laura; Sotelo-Hitschfeld, Pamela; König, Christine; Sinica, Viktor; Wyatt, Amanda; Winter, Zoltan; Hein, Alexander; Touska, Filip; Reinhardt, Susanne; Tragl, Aaron; Kusuda, Ricardo; Wartenberg, Philipp; Sclaroff, Allen; Pfeifer, John D.; Ectors, Fabien; Dahl, Andreas; Freichel, Marc; Vlachova, Viktorie; Brauchi, Sebastian; Roza, Carolina; Boehm, Ulrich; Clapham, David E.; Lennerz, Jochen K.; Zimmermann, Katharina (2021). "Odontoblast TRPC5 channels signal cold pain in teeth". Science Advances. 7 (13): eabf5567. doi:10.1126/sciadv.abf5567. PMC 7997515. PMID 33771873.

[pmid18172497-11] Xu SZ, Sukumar P, Zeng F, Li J, Jairaman A, English A, Naylor J, Ciurtin C, Majeed Y, Milligan CJ, Bahnasi YM, Al-Shawaf E, Porter KE, Jiang LH, Emery P, Sivaprasadarao A, Beech DJ (January 2008). "TRPC channel activation by extracellular thioredoxin". Nature. 451 (7174): 69–72. doi:10.1038/nature06414. PMC 2645077. PMID 18172497.

[pmid18204473-12] Bahnasi YM, Wright HM, Milligan CJ, Dedman AM, Zeng F, Hopkins PM, Bateson AN, Beech DJ (April 2008). "Modulation of TRPC5 cation channels by halothane, chloroform and propofol". Br. J. Pharmacol. 153 (7): 1505–12. doi:10.1038/sj.bjp.0707689. PMC 2437913. PMID 18204473.

[pmid12858178-13] Greka A, Navarro B, Oancea E, Duggan A, Clapham DE (August 2003). "TRPC5 is a regulator of hippocampal neurite length and growth cone morphology". Nat. Neurosci. 6 (8): 837–45. doi:10.1038/nn1092. PMID 12858178. S2CID 7523946.

[pmid12857742-14] Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE (October 2003). "Formation of novel TRPC channels by complex subunit interactions in embryonic brain". J. Biol. Chem. 278 (40): 39014–9. doi:10.1074/jbc.M306705200. PMID 12857742.

[pmid12032305-15] Hofmann T, Schaefer M, Schultz G, Gudermann T (May 2002). "Subunit composition of mammalian transient receptor potential channels in living cells". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7461–6. doi:10.1073/pnas.102596199. PMC 124253. PMID 12032305.

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