CD2
Template:PBB CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor.[1] Template:PBB Summary
Function
It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells.[2]
In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells.[3]
Classification
Due to its structural characteristics, CD2 is a member of the immunoglobulin superfamily; it possesses two immunoglobulin-like domains in its extracellular portion.[3]
References
- ^ Uniprot database entry for CD2 (accession number P06729)
- ^ Wilkins A, Yang W, Yang J (2003). "Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design". Curr Protein Pept Sci. 4 (5): 367–73. doi:10.2174/1389203033487063. PMID 14529530.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ a b Yang J, Ye Y, Carroll A, Yang W, Lee H (2001). "Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation". Curr Protein Pept Sci. 2 (1): 1–17. doi:10.2174/1389203013381251. PMID 12369898.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
Further reading
External links
- CD2+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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