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Protein CD8A PDB 1akj.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases CD8A, CD8, Leu2, MAL, p32, CD8a molecule
External IDs MGI: 88346 HomoloGene: 133777 GeneCards: 925
RNA expression pattern
PBB GE CD8A 205758 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 2: 86.78 – 86.81 Mb Chr 6: 71.37 – 71.38 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

CD8a (Cluster of Differentiation 8a), is a human gene.[3]


The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified.[3]


CD8A has been shown to interact with:

See also[edit]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: CD8A CD8a molecule". 
  4. ^ Doucey MA, Goffin L, Naeher D, Michielin O, Baumgärtner P, Guillaume P, Palmer E, Luescher IF (January 2003). "CD3 delta establishes a functional link between the T cell receptor and CD8". J. Biol. Chem. 278 (5): 3257–64. doi:10.1074/jbc.M208119200. PMID 12215456. 
  5. ^ a b Gao GF, Willcox BE, Wyer JR, Boulter JM, O'Callaghan CA, Maenaka K, Stuart DI, Jones EY, Van Der Merwe PA, Bell JI, Jakobsen BK (May 2000). "Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha". J. Biol. Chem. 275 (20): 15232–8. doi:10.1074/jbc.275.20.15232. PMID 10809759. 
  6. ^ Gao GF, Tormo J, Gerth UC, Wyer JR, McMichael AJ, Stuart DI, Bell JI, Jones EY, Jakobsen BK (June 1997). "Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2". Nature. 387 (6633): 630–4. doi:10.1038/42523. PMID 9177355. 
  7. ^ Sanders SK, Giblin PA, Kavathas P (September 1991). "Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class 1 molecule on cytotrophoblasts". J. Exp. Med. 174 (3): 737–40. doi:10.1084/jem.174.3.737. PMC 2118947free to read. PMID 1908512. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.