TLR10

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TLR10
PBB Protein TLR10 image.jpg
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases TLR10, CD290, toll like receptor 10
External IDs OMIM: 606270 HomoloGene: 12809 GeneCards: TLR10
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001017388
NM_001195106
NM_001195107
NM_001195108
NM_030956

n/a

RefSeq (protein)

NP_001017388
NP_001182035
NP_001182036
NP_001182037
NP_112218

n/a

Location (UCSC) Chr 4: 38.77 – 38.78 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Toll-like receptor 10 is a protein that in humans is encoded by the TLR10 gene.[2] TLR10 has also been designated as CD290 (cluster of differentiation 290).

Function[edit]

The protein encoded by this gene is a member of the toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Its exact function is not known. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Chuang T, Ulevitch RJ (Mar 2001). "Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells". Biochim Biophys Acta. 1518 (1-2): 157–61. doi:10.1016/s0167-4781(00)00289-x. PMID 11267672. 
  3. ^ "Entrez Gene: TLR10 toll-like receptor 10". 

Further reading[edit]

External links[edit]