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Fc fragment of IgG, high affinity Ia, receptor (CD64)
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FCGR1A ; CD64; CD64A; FCRI; IGFR1
External IDs OMIM146760 MGI95498 HomoloGene475 ChEMBL: 5349 GeneCards: FCGR1A Gene
RNA expression pattern
PBB GE FCGR1A 216950 s at tn.png
PBB GE FCGR1A 214511 x at tn.png
More reference expression data
Species Human Mouse
Entrez 2209 14129
Ensembl ENSG00000150337 ENSMUSG00000015947
UniProt P12314 P26151
RefSeq (mRNA) NM_000566 NM_010186
RefSeq (protein) NP_000557 NP_034316
Location (UCSC) Chr 1:
149.78 – 149.79 Mb
Chr 3:
96.28 – 96.29 Mb
PubMed search [1] [2]

High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene.[1][2][3]


FCGR1A has been shown to interact with FCAR.[4] The FcgRI binds the Fc portion of IgG and causes activation of the host cell via an intercellular ITAM motif. [5]


  1. ^ Maresco DL, Chang E, Theil KS, Francke U, Anderson CL (September 1996). "The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21". Cytogenetics and Cell Genetics 73 (3): 157–63. doi:10.1159/000134330. PMID 8697799. 
  2. ^ Maresco DL, Blue LE, Culley LL, Kimberly RP, Anderson CL, Theil KS (November 1998). "Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1". Cytogenetics and Cell Genetics 82 (1-2): 71–4. doi:10.1159/000015067. PMID 9763663. 
  3. ^ "Entrez Gene: FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)". 
  4. ^ Morton HC, van den Herik-Oudijk IE, Vossebeld P, Snijders A, Verhoeven AJ, Capel PJ, van de Winkel JG (Dec 1995). "Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association". The Journal of Biological Chemistry 270 (50): 29781–7. doi:10.1074/jbc.270.50.29781. PMID 8530370. 
  5. ^ The function of Fcγ receptors in dendritic cells and macrophages Martin Guilliams Pierre Bruhns Yvan Saeys Hamida Hammad and Bart N. Lambrecht FEBRUARY 2014 | VOLUME 14 Nature Reviews Immunology

Further reading[edit]