From Wikipedia, the free encyclopedia
Jump to: navigation, search
Available structures
PDB Ortholog search: PDBe RCSB
Aliases FCGR1A, CD64, CD64A, FCRI, IGFR1, Fc fragment of IgG receptor Ia
External IDs MGI: 95498 HomoloGene: 475 GeneCards: FCGR1A
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for FCGR1A
Genomic location for FCGR1A
Band 1q21.2 Start 149,782,671 bp[1]
End 149,792,518 bp[1]
RNA expression pattern
PBB GE FCGR1A 216950 s at fs.png

PBB GE FCGR1A 214511 x at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 149.78 – 149.79 Mb Chr 1: 96.28 – 96.29 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene.[5][6][7]


FCGR1A has been shown to interact with FCAR.[8] The FcgRI binds the Fc portion of IgG and causes activation of the host cell via an intercellular ITAM motif. [9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000150337 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015947 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Maresco DL, Chang E, Theil KS, Francke U, Anderson CL (September 1996). "The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21". Cytogenetics and Cell Genetics. 73 (3): 157–63. doi:10.1159/000134330. PMID 8697799. 
  6. ^ Maresco DL, Blue LE, Culley LL, Kimberly RP, Anderson CL, Theil KS (November 1998). "Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1". Cytogenetics and Cell Genetics. 82 (1-2): 71–4. doi:10.1159/000015067. PMID 9763663. 
  7. ^ "Entrez Gene: FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)". 
  8. ^ Morton HC, van den Herik-Oudijk IE, Vossebeld P, Snijders A, Verhoeven AJ, Capel PJ, van de Winkel JG (Dec 1995). "Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association". The Journal of Biological Chemistry. 270 (50): 29781–7. doi:10.1074/jbc.270.50.29781. PMID 8530370. 
  9. ^ The function of Fcγ receptors in dendritic cells and macrophages Martin Guilliams Pierre Bruhns Yvan Saeys Hamida Hammad and Bart N. Lambrecht FEBRUARY 2014 | VOLUME 14 Nature Reviews Immunology

Further reading[edit]