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Protein SIRPB1 PDB 2d9c.png
Available structures
PDBHuman UniProt search: PDBe RCSB
AliasesSIRPB1, CD172b, SIRP-BETA-1, signal regulatory protein beta 1
External IDsMGI: 3779828 HomoloGene: 82993 GeneCards: SIRPB1
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for SIRPB1
Genomic location for SIRPB1
Band20p13Start1,563,521 bp[1]
End1,620,061 bp[1]
RNA expression pattern
PBB GE SIRPB1 217240 at fs.png

PBB GE SIRPB1 206934 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)


Location (UCSC)Chr 20: 1.56 – 1.62 MbChr 3: 15.5 – 15.58 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene.[5][6][7] SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B).

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.[7]


SIRPB1 has been shown to interact with TYROBP.[8][9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101307 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000095028 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kharitonenkov A; Chen Z; Sures I; Wang H; Schilling J; Ullrich A (April 1997). "A family of proteins that inhibit signalling through tyrosine kinase receptors". Nature. 386 (6621): 181–6. Bibcode:1997Natur.386..181K. doi:10.1038/386181a0. PMID 9062191. 
  6. ^ van den Berg TK; van Beek EM; Buhring HJ; Colonna M; Hamaguchi M; Howard CJ; Kasuga M; Liu Y; Matozaki T; Neel BG; Parkos CA; Sano S; Vignery A; Vivier E; Wright M; Zawatzky R; Barclay AN (December 2005). "A nomenclature for signal regulatory protein family members". J Immunol. 175 (12): 7788–9. doi:10.4049/jimmunol.175.12.7788. PMID 16339511. 
  7. ^ a b "Entrez Gene: SIRPB1 signal-regulatory protein beta 1". 
  8. ^ Dietrich, J; Cella M; Seiffert M; Bühring H J; Colonna M (January 2000). "Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells". J. Immunol. UNITED STATES. 164 (1): 9–12. doi:10.4049/jimmunol.164.1.9. ISSN 0022-1767. PMID 10604985. 
  9. ^ Tomasello, E; Cant C; Bühring H J; Vély F; André P; Seiffert M; Ullrich A; Vivier E (August 2000). "Association of signal-regulatory proteins beta with KARAP/DAP-12". Eur. J. Immunol. GERMANY. 30 (8): 2147–56. doi:10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1. ISSN 0014-2980. PMID 10940905. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.