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Signal-regulatory protein beta 1
Protein SIRPB1 PDB 2d9c.png
PDB rendering based on 2d9c.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SIRPB1 ; CD172b; SIRP-BETA-1
External IDs OMIM603889 HomoloGene82993 GeneCards: SIRPB1 Gene
RNA expression pattern
PBB GE SIRPB1 206934 at tn.png
PBB GE SIRPB1 217240 at tn.png
More reference expression data
Species Human Mouse
Entrez 10326 320832
Ensembl ENSG00000101307 ENSMUSG00000095788
UniProt O00241 Q6F5F2
RefSeq (mRNA) NM_001083910 NM_001002898
RefSeq (protein) NP_001077379 NP_001002898
Location (UCSC) Chr 20:
1.56 – 1.62 Mb
Chr 3:
15.37 – 15.43 Mb
PubMed search [1] [2]

Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene.[1][2][3] SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B).

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.[3]


SIRPB1 has been shown to interact with TYROBP.[4][5]


  1. ^ Kharitonenkov A, Chen Z, Sures I, Wang H, Schilling J, Ullrich A (April 1997). "A family of proteins that inhibit signalling through tyrosine kinase receptors". Nature 386 (6621): 181–6. doi:10.1038/386181a0. PMID 9062191. 
  2. ^ van den Berg TK, van Beek EM, Buhring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano S, Vignery A, Vivier E, Wright M, Zawatzky R, Barclay AN (December 2005). "A nomenclature for signal regulatory protein family members". J Immunol 175 (12): 7788–9. doi:10.4049/jimmunol.175.12.7788. PMID 16339511. 
  3. ^ a b "Entrez Gene: SIRPB1 signal-regulatory protein beta 1". 
  4. ^ Dietrich, J; Cella M; Seiffert M; Bühring H J; Colonna M (January 2000). "Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells". J. Immunol. (UNITED STATES) 164 (1): 9–12. doi:10.4049/jimmunol.164.1.9. ISSN 0022-1767. PMID 10604985. 
  5. ^ Tomasello, E; Cant C; Bühring H J; Vély F; André P; Seiffert M; Ullrich A; Vivier E (August 2000). "Association of signal-regulatory proteins beta with KARAP/DAP-12". Eur. J. Immunol. (GERMANY) 30 (8): 2147–56. doi:10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1. ISSN 0014-2980. PMID 10940905. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.