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CD248 molecule, endosialin
Symbols CD248 ; CD164L1; TEM1
External IDs OMIM606064 MGI1917695 HomoloGene10699 GeneCards: CD248 Gene
RNA expression pattern
PBB GE CD248 219025 at tn.png
More reference expression data
Species Human Mouse
Entrez 57124 70445
Ensembl ENSG00000174807 ENSMUSG00000056481
UniProt Q9HCU0 Q91V98
RefSeq (mRNA) NM_020404 NM_054042
RefSeq (protein) NP_065137 NP_473383
Location (UCSC) Chr 11:
66.31 – 66.32 Mb
Chr 19:
5.07 – 5.07 Mb
PubMed search [1] [2]

Endosialin is a protein that in humans is encoded by the CD248 gene.[1][2][3]

Endosialin is a member of the “Group XIV”, a novel family of C-type lectin transmembrane receptors which play a role not only in cell-cell adhesion processes but also in host defence. This family comprise two other members, CD93 and Thrombomodulin which are better characterized.

The function of endosialin remains elusive, but its expression has been associated with angiogenesis in the embryo, uterus and in tumor development and growth.[4]

See also[edit]


  1. ^ St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science 289 (5482): 1197–202. doi:10.1126/science.289.5482.1197. PMID 10947988. 
  2. ^ Christian S, Ahorn H, Koehler A, Eisenhaber F, Rodi HP, Garin-Chesa P, Park JE, Rettig WJ, Lenter MC (May 2001). "Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium". J Biol Chem 276 (10): 7408–14. doi:10.1074/jbc.M009604200. PMID 11084048. 
  3. ^ "Entrez Gene: CD248 CD248 molecule, endosialin". 
  4. ^ Rupp C, Dolznig H, Puri C, Sommergruber W, Kerjaschki D, Rettig WJ, Garin-Chesa P (2006). "Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis.". Cancer Immun 6: 10. PMID 16875435. 

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