CD248

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CD248
Identifiers
Aliases CD248, CD164L1, TEM1, CD248 molecule
External IDs MGI: 1917695 HomoloGene: 10699 GeneCards: 57124
RNA expression pattern
PBB GE CD248 219025 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020404

NM_054042

RefSeq (protein)

NP_065137.1

NP_473383.1

Location (UCSC) Chr 11: 66.31 – 66.32 Mb Chr 19: 5.07 – 5.07 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Endosialin is a protein that in humans is encoded by the CD248 gene.[3][4][5]

Endosialin is a member of the “Group XIV”, a novel family of C-type lectin transmembrane receptors which play a role not only in cell–cell adhesion processes but also in host defence. This family comprise two other members, CD93 and Thrombomodulin which are better characterized.

The function of endosialin remains elusive, but its expression has been associated with angiogenesis in the embryo, uterus and in tumor development and growth.[6]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science. 289 (5482): 1197–202. doi:10.1126/science.289.5482.1197. PMID 10947988. 
  4. ^ Christian S, Ahorn H, Koehler A, Eisenhaber F, Rodi HP, Garin-Chesa P, Park JE, Rettig WJ, Lenter MC (May 2001). "Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium". J Biol Chem. 276 (10): 7408–14. doi:10.1074/jbc.M009604200. PMID 11084048. 
  5. ^ "Entrez Gene: CD248 CD248 molecule, endosialin". 
  6. ^ Rupp C, Dolznig H, Puri C, Sommergruber W, Kerjaschki D, Rettig WJ, Garin-Chesa P (2006). "Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis.". Cancer Immun. 6: 10. PMID 16875435. 

Further reading[edit]

External links[edit]