Decoy receptor 2

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TNFRSF10D
Identifiers
AliasesTNFRSF10D, CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD, tumor necrosis factor receptor superfamily member 10d, TNF receptor superfamily member 10d
External IDsHomoloGene: 136778 GeneCards: TNFRSF10D
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for TNFRSF10D
Genomic location for TNFRSF10D
Band8p21.3Start23,135,588 bp[1]
End23,164,027 bp[1]
RNA expression pattern
PBB GE TNFRSF10D 210654 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003840

n/a

RefSeq (protein)

NP_003831

n/a

Location (UCSC)Chr 8: 23.14 – 23.16 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Decoy receptor 2 (DCR2), also known as TRAIL receptor 4 (TRAILR4) and tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), is a human cell surface receptor of the TNF-receptor superfamily.[3][4][5]

Function[edit]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplasmic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173530 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:".
  3. ^ Marsters SA, Sheridan JP, Pitti RM, Huang A, Skubatch M, Baldwin D, Yuan J, Gurney A, Goddard AD, Godowski P, Ashkenazi A (Feb 1998). "A novel receptor for Apo2L/TRAIL contains a truncated death domain". Curr Biol. 7 (12): 1003–6. doi:10.1016/S0960-9822(06)00422-2. PMID 9382840.
  4. ^ Pan G, Ni J, Yu G, Wei YF, Dixit VM (Apr 1998). "TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling" (PDF). FEBS Lett. 424 (1–2): 41–5. doi:10.1016/S0014-5793(98)00135-5. PMID 9537512.
  5. ^ a b "Entrez Gene: TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain".

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.