Decoy receptor 2

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Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
External IDs OMIM603614 HomoloGene136778 GeneCards: TNFRSF10D Gene
RNA expression pattern
PBB GE TNFRSF10D 210654 at tn.png
More reference expression data
Species Human Mouse
Entrez 8793 n/a
Ensembl ENSG00000173530 n/a
UniProt Q9UBN6 n/a
RefSeq (mRNA) NM_003840 n/a
RefSeq (protein) NP_003831 n/a
Location (UCSC) Chr 8:
23.14 – 23.16 Mb
PubMed search [1] n/a

Decoy receptor 2 (DCR2), also known as TRAIL receptor 4 (TRAILR4) and tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), is a human cell surface receptor of the TNF-receptor superfamily.[1][2][3]


The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplasmic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.[3]


  1. ^ Marsters SA, Sheridan JP, Pitti RM, Huang A, Skubatch M, Baldwin D, Yuan J, Gurney A, Goddard AD, Godowski P, Ashkenazi A (Feb 1998). "A novel receptor for Apo2L/TRAIL contains a truncated death domain". Curr Biol 7 (12): 1003–6. doi:10.1016/S0960-9822(06)00422-2. PMID 9382840. 
  2. ^ Pan G, Ni J, Yu G, Wei YF, Dixit VM (Apr 1998). "TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling". FEBS Lett 424 (1-2): 41–5. doi:10.1016/S0014-5793(98)00135-5. PMID 9537512. 
  3. ^ a b "Entrez Gene: TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.