Oxytocin receptor: Difference between revisions

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Oxytocin receptors are expressed by the [[myoepithelial cell]]s of the [[mammary gland]], and in both the [[myometrium]] and [[endometrium]] of the [[uterus]] at the end of [[pregnancy]].
Oxytocin receptors are expressed by the [[myoepithelial cell]]s of the [[mammary gland]], and in both the [[myometrium]] and [[endometrium]] of the [[uterus]] at the end of [[pregnancy]].
The oxytocin-oxytocin receptor system plays an important role as an inducer of uterine contractions during [[parturition]] and of milk ejection.
The oxytocin-oxytocin receptor system plays an important role as an inducer of uterine contractions during [[parturition]] and of milk ejection.
>.


The gene is believed to play a major role in social, cognitive, and emotional behavior. <ref>Maud, C., Ryan, J., McIntosh, J., & Olsson, C. (2018, May 29). The role of oxytocin receptor gene (oxtr) dna methylation (dnam) in human social and emotional functioning: A systematic narrative review. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975530/<ref>. An increase in this gene expression is believed to be associated with unemotional traits, rigid thinking, and problems with facial and emotional recognition. A reduction in this gene is believed to lead to prenatal stress, postnatal depression, and social anxiety. <ref>Maud, C., Ryan, J., McIntosh, J., & Olsson, C. (2018, May 29). The role of oxytocin receptor gene (oxtr) dna methylation (dnam) in human social and emotional functioning: A systematic narrative review. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975530/<ref>. Further research must be gathered before concluding these findings, however strong evidence is pointing in this direction. OXTR is also strongly correlated with the amygadala and fear-related responses. Studies suggest that OXTR methylation, which downregulates oxytocin mechanisms, results in increased gray matter further associating to a decrease in parasympathetic tone. <ref>Lancaster K;Goldbeck L;Puglia MH;Morris JP;Connelly JJ;. (n.d.). DNA methylation OF Oxtr is associated with parasympathetic nervous system activity and amygdala morphology. https://pubmed.ncbi.nlm.nih.gov/30257007/ <ref>
Oxytocin receptors are also present in the [[central nervous system]]. These receptors modulate a variety of behaviors, including stress and anxiety, social memory and recognition, sexual and aggressive behaviors, bonding (affiliation) and maternal behavior.<ref name="isbn0-387-30348-0">{{cite book | vauthors = Caldwell HK, Young WS | veditors = Lajtha A, Ramon L | title = Handbook of Neurochemistry and Molecular Neurobiology | edition = 3rd | publisher = Springer | location = Berlin | year = 2006 | pages = 573–607 | chapter = Oxytocin and Vasopressin: Genetics and Behavioral Implications | isbn = 978-0-387-30348-2 }}</ref><ref name="pmid16468232">{{cite journal | vauthors = Kiss A, Mikkelsen JD | title = Oxytocin--anatomy and functional assignments: a minireview | journal = Endocrine Regulations | volume = 39 | issue = 3 | pages = 97–105 | date = September 2005 | pmid = 16468232 | url = http://www.aepress.sk/_downloads/dl.php?from=pubmed&journal=ER&file=2005_03_97.pdf }}</ref><ref name="pmid18655888">{{cite book | vauthors = Veenema AH, Neumann ID | chapter = Central vasopressin and oxytocin release: regulation of complex social behaviours | volume = 170 | pages = 261–76 | year = 2008 | pmid = 18655888 | doi = 10.1016/S0079-6123(08)00422-6 | isbn = 978-0-444-53201-5 | series = Progress in Brain Research | title = Advances in Vasopressin and Oxytocin — from Genes to Behaviour to Disease }}</ref> (See the [[oxytocin]] article for more details.)


In some mammals, oxytocin receptors are also found in the [[kidney]] and [[heart]].
In some mammals, oxytocin receptors are also found in the [[kidney]] and [[heart]].

Revision as of 05:43, 15 April 2021

OXTR
Identifiers
AliasesOXTR, OT-R, oxytocin receptor
External IDsOMIM: 167055; MGI: 109147; HomoloGene: 20255; GeneCards: OXTR; OMA:OXTR - orthologs
Orthologs
SpeciesHumanMouse
Entrez

5021

18430

Ensembl

ENSG00000180914

ENSMUSG00000049112

UniProt

P30559

P97926

RefSeq (mRNA)

NM_000916

NM_001081147

RefSeq (protein)

NP_000907
NP_001341582
NP_001341583
NP_001341584
NP_001341585

NP_001074616

Location (UCSC)n/aChr 6: 112.45 – 112.47 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The oxytocin receptor, also known as OXTR, is a protein which functions as receptor for the hormone and neurotransmitter oxytocin.[4][5] In humans, the oxytocin receptor is encoded by the OXTR gene[6][7] which has been localized to human chromosome 3p25.[8]

Evolutionary tree of the oxytocin, vasotocin, mesotocin and isotocin receptors and their ligands. From Koechbach et al.[9]

Function and location

The OXTR protein belongs to the G-protein coupled receptor family, specifically Gq,[4] and acts as a receptor for oxytocin. Its activity is mediated by G proteins that activate several different second messenger systems.[10][11]

Oxytocin receptors are expressed by the myoepithelial cells of the mammary gland, and in both the myometrium and endometrium of the uterus at the end of pregnancy. The oxytocin-oxytocin receptor system plays an important role as an inducer of uterine contractions during parturition and of milk ejection. >. 

The gene is believed to play a major role in social, cognitive, and emotional behavior. Cite error: A <ref> tag is missing the closing </ref> (see the help page). specifically, oxytocin exerts a prosexual and prosocial effect in this region.[12]

Polymorphism

The receptors for oxytocin (OXTR) have genetic differences with varied effects on individual behavior. The polymorphism (rs53576) occurs on the third intron of OXTR in three types: GG, AG, AA. The GG allele is connected with oxytocin levels in people [citation needed]. A-allele carrier individuals are associated with more sensitivity to stress, fewer social skills, and more mental health issues than the GG-carriers.[13][qualify evidence]

In a study looking at empathy and stress, individuals with the allele GG scored higher than A-carrier individuals in a "Reading the Mind in the Eyes" test. GG carriers, with their naturally higher levels of oxytocin , were better able to distinguish between emotions.[citation needed] A-allele carriers responded with more stress to stressful situations than GG-allele carriers.[14][further explanation needed] A-allele carriers had lower scores on psychological resources, like optimism, mastery, and self-esteem, than GG individuals when measured with factor analysis for depressive symptomology and psychological resources, along with the Beck Depression Inventory. A-allele carriers had higher depressive symptomology and lower psychological resources than GG individuals.[13][qualify evidence] A-allele individuals scored lower in human sociality than GG people on a Tridimensional Personality Questionnaire. AA individuals had the lowest amygdala activation while processing emotionally salient information and those with GG had the highest activity when tested using BOLD during an fMRI.[15]

Some evidence suggests an associated with OXTR gene polymorphism and Autism Spectrum Disorder (ASD). Studies have done research focusing on variants in the third intron of the gene, a region that is strongly correlated with personality traits and ASD. OXTR knockout mice have shown abnormal behaviors such as social impairments and aggressiveness. These abnormalities can be reduced with oxytocin or oxytocin agonist administration. Overall, the study suggests that rare variants are considerably more abundant in individuals with ASD compared to that of a normal individual, however further research with larger sample sizes must be completed before concluding any information.Cite error: A <ref> tag is missing the closing </ref> (see the help page).[quantify][additional citation(s) needed]

Ligands

Several selective ligands for the oxytocin receptor have recently been developed, but close similarity between the oxytocin and related vasopressin receptors make it difficult to achieve high selectivity with peptide derivatives.[16][17] However the search for a druggable, non-peptide template has led to several potent, highly selective, orally bioavailable oxytocin antagonists.[18]

Agonists

Peptide
Non-peptide

Antagonists

Peptide
Non-peptide

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049112 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ a b Gimpl G, Fahrenholz F (April 2001). "The oxytocin receptor system: structure, function, and regulation". Physiological Reviews. 81 (2): 629–83. doi:10.1152/physrev.2001.81.2.629. PMID 11274341. S2CID 13265083.
  5. ^ Zingg HH, Laporte SA (July 2003). "The oxytocin receptor". Trends in Endocrinology and Metabolism. 14 (5): 222–7. doi:10.1016/S1043-2760(03)00080-8. PMID 12826328. S2CID 21540056.
  6. ^ EntrezGene 5021
  7. ^ Kimura T, Tanizawa O, Mori K, Brownstein MJ, Okayama H (April 1992). "Structure and expression of a human oxytocin receptor". Nature. 356 (6369): 526–9. Bibcode:1992Natur.356..526K. doi:10.1038/356526a0. PMID 1313946. S2CID 4273722.
  8. ^ Simmons CF, Clancy TE, Quan R, Knoll JH (April 1995). "The oxytocin receptor gene (OXTR) localizes to human chromosome 3p25 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids". Genomics. 26 (3): 623–5. doi:10.1016/0888-7543(95)80188-R. PMID 7607693.
  9. ^ Koehbach J, Stockner T, Bergmayr C, Muttenthaler M, Gruber CW (February 2013). "Insights into the molecular evolution of oxytocin receptor ligand binding". Biochemical Society Transactions. 41 (1): 197–204. doi:10.1042/BST20120256. PMC 3634130. PMID 23356283.
  10. ^ Devost D, Wrzal P, Zingg HH (2008). "Oxytocin receptor signalling". Advances in Vasopressin and Oxytocin — from Genes to Behaviour to Disease. Progress in Brain Research. Vol. 170. pp. 167–76. doi:10.1016/S0079-6123(08)00415-9. ISBN 978-0-444-53201-5. PMID 18655881.
  11. ^ Gimpl G, Reitz J, Brauer S, Trossen C (2008). "Oxytocin receptors: ligand binding, signalling and cholesterol dependence". Advances in Vasopressin and Oxytocin — from Genes to Behaviour to Disease. Progress in Brain Research. Vol. 170. pp. 193–204. doi:10.1016/S0079-6123(08)00417-2. ISBN 978-0-444-53201-5. PMID 18655883.
  12. ^ Cite error: The named reference Oxytocinergic circuit was invoked but never defined (see the help page).
  13. ^ a b Saphire-Bernstein S, Way BM, Kim HS, Sherman DK, Taylor SE (September 2011). "Oxytocin receptor gene (OXTR) is related to psychological resources". Proceedings of the National Academy of Sciences of the United States of America. 108 (37): 15118–22. Bibcode:2011PNAS..10815118S. doi:10.1073/pnas.1113137108. PMC 3174632. PMID 21896752.
  14. ^ Rodrigues SM, Saslow LR, Garcia N, John OP, Keltner D (December 2009). "Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans". Proceedings of the National Academy of Sciences of the United States of America. 106 (50): 21437–41. Bibcode:2009PNAS..10621437R. doi:10.1073/pnas.0909579106. PMC 2795557. PMID 19934046.
  15. ^ Tost H, Kolachana B, Hakimi S, Lemaitre H, Verchinski BA, Mattay VS, Weinberger DR, Meyer-Lindenberg A (August 2010). "A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function". Proceedings of the National Academy of Sciences of the United States of America. 107 (31): 13936–41. Bibcode:2010PNAS..10713936T. doi:10.1073/pnas.1003296107. PMC 2922278. PMID 20647384.
  16. ^ Chini B, Manning M (August 2007). "Agonist selectivity in the oxytocin/vasopressin receptor family: new insights and challenges". Biochemical Society Transactions. 35 (Pt 4): 737–41. doi:10.1042/BST0350737. PMID 17635137.
  17. ^ a b Manning M, Stoev S, Chini B, Durroux T, Mouillac B, Guillon G (2008). "Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: Research tools and potential therapeutic agents☆". Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents. Progress in Brain Research. Vol. 170. pp. 473–512. doi:10.1016/S0079-6123(08)00437-8. ISBN 978-0-444-53201-5. PMID 18655903.
  18. ^ Borthwick AD (September 2010). "Oral oxytocin antagonists". Journal of Medicinal Chemistry. 53 (18): 6525–38. doi:10.1021/jm901812z. PMID 20550119.
  19. ^ Rahman Z, Resnick L, Rosenzweig-Lipson SJ, Ring RH,"Methods of treatment using oxytocin receptor agonists", US patent application 2007/0117794, published 2007-05-24 , assigned to Wyeth Corp 
  20. ^ Ring RH, Schechter LE, Leonard SK, Dwyer JM, Platt BJ, Graf R, Grauer S, Pulicicchio C, Resnick L, Rahman Z, Sukoff Rizzo SJ, Luo B, Beyer CE, Logue SF, Marquis KL, Hughes ZA, Rosenzweig-Lipson S (January 2010). "Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist". Neuropharmacology. 58 (1): 69–77. doi:10.1016/j.neuropharm.2009.07.016. PMID 19615387. S2CID 8592340.
  21. ^ a b Borthwick AD, Liddle J (January 2013). "Retosiban and Epelsiban: Potent and Selective Orally available Oxytocin Antagonists". In Domling A (ed.). Methods and Principles in Medicinal Chemistry: Protein-Protein Interactions in Drug Discovery. Weinheim: Wiley-VCH. pp. 225–256. doi:10.1002/9783527648207.ch10. ISBN 978-3-527-33107-9.
  22. ^ Williams PD, Anderson PS, Ball RG, Bock MG, Carroll L, Chiu SH, Clineschmidt BV, Culberson JC, Erb JM, Evans BE (March 1994). "1-((7,7-Dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo [2.2.1]-heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperaz ine (L-368,899): an orally bioavailable, non-peptide oxytocin antagonist with potential utility for managing preterm labor". Journal of Medicinal Chemistry. 37 (5): 565–71. doi:10.1021/jm00031a004. PMID 8126695.
  23. ^ Boccia ML, Goursaud AP, Bachevalier J, Anderson KD, Pedersen CA (September 2007). "Peripherally administered non-peptide oxytocin antagonist, L368,899, accumulates in limbic brain areas: a new pharmacological tool for the study of social motivation in non-human primates". Hormones and Behavior. 52 (3): 344–51. doi:10.1016/j.yhbeh.2007.05.009. PMC 2712625. PMID 17583705.
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  25. ^ Wyatt PG, Allen MJ, Chilcott J, Foster A, Livermore DG, Mordaunt JE, Scicinski J, Woollard PM (May 2002). "Identification of potent and selective oxytocin antagonists. Part 1: indole and benzofuran derivatives". Bioorganic & Medicinal Chemistry Letters. 12 (10): 1399–404. doi:10.1016/S0960-894X(02)00159-2. PMID 11992786.
  26. ^ Ring RH, Malberg JE, Potestio L, Ping J, Boikess S, Luo B, Schechter LE, Rizzo S, Rahman Z, Rosenzweig-Lipson S (April 2006). "Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications". Psychopharmacology. 185 (2): 218–25. doi:10.1007/s00213-005-0293-z. PMID 16418825. S2CID 13647805.

External links

Wikimedia Commons has media related to Oxytocin receptors.

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