NCR3

NCR3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3NOI, 3PV6
Identifiers
Aliases	NCR3, 1C7, CD337, LY117, MALS, NKp30, natural cytotoxicity triggering receptor 3
External IDs	OMIM: 611550; HomoloGene: 51827; GeneCards: NCR3; OMA:NCR3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.33 Start 31,588,895 bp End 31,593,006 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood lymph node spleen appendix gonad bone marrow monocyte apex of heart mucosa of transverse colon n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding protein homodimerization activity cell adhesion molecule binding protein binding identical protein binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process susceptibility to T cell mediated cytotoxicity heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules inflammatory response cell recognition positive regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target immune response susceptibility to natural killer cell mediated cytotoxicity homophilic cell adhesion via plasma membrane adhesion molecules regulation of immune response immune response-activating cell surface receptor signaling pathway natural killer cell activation immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 259197 n/a Ensembl ENSG00000237103 ENSG00000236979 ENSG00000206430 ENSG00000237808 ENSG00000236315 ENSG00000223833 ENSG00000225211 ENSG00000204475 n/a UniProt O14931 n/a RefSeq (mRNA) NM_001145466 NM_001145467 NM_147130 n/a RefSeq (protein) NP_001138938 NP_001138939 NP_667341 n/a Location (UCSC) Chr 6: 31.59 – 31.59 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Natural cytotoxicity triggering receptor 3 is a protein that in humans is encoded by the NCR3 gene. NCR3 has also been designated as CD337 (cluster of differentiation 337) and as NKp30.

Further reading

• Djeu JY, Jiang K, Wei S (2002). "A view to a kill: signals triggering cytotoxicity". Clin. Cancer Res. 8 (3): 636–40. PMID 11895890.
• Holzinger I, de Baey A, Messer G, et al. (1995). "Cloning and genomic characterization of LST1: a new gene in the human TNF region". Immunogenetics. 42 (5): 315–22. doi:10.1007/BF00179392. PMID 7590964. S2CID 19916860.
• de Baey A, Fellerhoff B, Maier S, et al. (1998). "Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing". Genomics. 45 (3): 591–600. doi:10.1006/geno.1997.4963. PMID 9367684.
• Neville MJ, Campbell RD (1999). "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC". J. Immunol. 162 (8): 4745–54. PMID 10202016.
• Pende D, Parolini S, Pessino A, et al. (1999). "Identification and Molecular Characterization of Nkp30, a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells". J. Exp. Med. 190 (10): 1505–16. doi:10.1084/jem.190.10.1505. PMC 2195691. PMID 10562324.
• Sivakamasundari R, Raghunathan A, Zhang CY, et al. (2000). "Expression and cellular localization of the protein encoded by the 1C7 gene: a recently described component of the MHC". Immunogenetics. 51 (8–9): 723–32. doi:10.1007/s002510000192. PMID 10941844. S2CID 27714493.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Le Bouteiller P, Barakonyi A, Giustiniani J, et al. (2003). "Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16963–8. doi:10.1073/pnas.012681099. PMC 139252. PMID 12486241.
• Augugliaro R, Parolini S, Castriconi R, et al. (2003). "Selective cross-talk among natural cytotoxicity receptors in human natural killer cells". Eur. J. Immunol. 33 (5): 1235–41. doi:10.1002/eji.200323896. PMID 12731048. S2CID 10724743.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Marcenaro E, Augugliaro R, Falco M, et al. (2004). "CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity". Eur. J. Immunol. 33 (12): 3367–76. doi:10.1002/eji.200324425. PMID 14635045. S2CID 40345630.
• Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nowbakht P, Ionescu MC, Rohner A, et al. (2005). "Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias". Blood. 105 (9): 3615–22. doi:10.1182/blood-2004-07-2585. PMID 15657183.
• Poggi A, Massaro AM, Negrini S, et al. (2005). "Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors". J. Immunol. 174 (5): 2653–60. doi:10.4049/jimmunol.174.5.2653. PMID 15728472.
• Vitale M, Della Chiesa M, Carlomagno S, et al. (2005). "NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor". Blood. 106 (2): 566–71. doi:10.1182/blood-2004-10-4035. PMID 15784725.
• Warren HS, Jones AL, Freeman C, et al. (2005). "Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan". J. Immunol. 175 (1): 207–12. doi:10.4049/jimmunol.175.1.207. PMID 15972650.
• Joyce MG, Gordon M, Tran P, et al. (2011). "Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site". PNAS. 108 (15): 6223–6228. Bibcode:2011PNAS..108.6223J. doi:10.1073/pnas.1100622108. PMC 3076882. PMID 21444796.

External links

• NCR3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Natural cytotoxicity triggering receptor 3 (NCR3)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.