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Revision as of 20:32, 12 February 2010

Noxiptiline
File:Noxiptiline.png
Clinical data
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one O-[2-dimethylamino)ethyl]oxime
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H22N2O
Molar mass294.39 g/mol

Noxiptiline (Agedal, Elronon, Nogedal), also known as noxiptyline and dibenzoxine, is a tricyclic antidepressant (TCA) that was introduced in Europe in the 1970s for the treatment of depression.[1][2][3] It has imipramine-like effects,[4] acting as a serotonin and norepinephrine reuptake inhibitor, among other properties.[5][6] Of the TCAs, noxiptiline has been shown to be one of the most effective, rivaling amitriptyline in clinical efficacy.[7][8]

See also

References

  1. ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 753. ISBN 3-88763-075-0. {{cite book}}: More than one of |pages= and |page= specified (help)
  2. ^ Aronson, Jeffrey Kenneth (2008). Meyler's Side Effects of Psychiatric Drugs (Meylers Side Effects). Amsterdam: Elsevier Science. p. 34. ISBN 0-444-53266-8. {{cite book}}: More than one of |pages= and |page= specified (help)
  3. ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. p. 4868. ISBN 0-412-54090-8. {{cite book}}: More than one of |pages= and |page= specified (help)
  4. ^ Mutschler, Ernst (1995). Drug actions: basic principles and theraputic aspects. Stuttgart, German: Medpharm Scientific Pub. p. 127. ISBN 0-8493-7774-9. {{cite book}}: More than one of |pages= and |page= specified (help)
  5. ^ Ernst Jucker; S. Ren; Soudijn, W.; Wijngaarden, I. van; M. Kumari; D. Poyner; M. Bushfield; H. Horikoshi; Fujiwara, Tamenari (2000). Progress in Drug Research, Volume 54 (Progress in Drug Research). Boston: Birkhauser. p. 81. ISBN 3-7643-6113-1. {{cite book}}: More than one of |pages= and |page= specified (help)CS1 maint: multiple names: authors list (link)
  6. ^ Barth N, Manns M, Muscholl E (1975). "Arrhythmias and inhibition of noradrenaline uptake caused by tricyclic antidepressants and chlorpromazine on the isolated perfused rabbit heart". Naunyn-Schmiedeberg's Archives of Pharmacology. 288 (2–3): 215–31.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  7. ^ Beresewicz M, Bidzińska E, Koszewska I, Puzyński S (1991). "[Results of using tricyclic antidepressive drugs in the treatment of endogenous depression (comparative analysis of 7 drugs)]". Psychiatria Polska (in Polish). 25 (3–4): 13–8. PMID 1687987.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  8. ^ Lingjaerde O, Asker T, Bugge A; et al. (1975). "Noxiptilin (Agedal)--a new tricyclic antidepressant with a faster onset of action? A double-blind, multicentre comparison with amitriptyline". Pharmakopsychiatrie, Neuro-Psychopharmakologie. 8 (1): 26–35. PMID 788000. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)



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