CD86: Difference between revisions
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{{About|the molecule|the compilation album|CD86 (album)}} |
{{About|the molecule|the compilation album|CD86 (album)}} |
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{{PBB|geneid=942}} |
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'''Cluster of Differentiation 86''' (also known as '''CD86''' and '''B7-2''') is a [[protein]] expressed on [[antigen-presenting cells]] that provides costimulatory signals necessary for [[T cell]] activation and survival. It is the [[ligand (biochemistry)|ligand]] for two different proteins on the T cell surface: [[CD28]] (for autoregulation and intercellular association) and [[CTLA-4]] (for attenuation of regulation and cellular disassociation). CD86 works in tandem with [[CD80]] to prime T cells. |
'''Cluster of Differentiation 86''' (also known as '''CD86''' and '''B7-2''') is a [[protein]] expressed on [[antigen-presenting cells]] that provides [[co-stimulation|costimulatory signals]] necessary for [[T cell]] activation and survival. It is the [[ligand (biochemistry)|ligand]] for two different proteins on the T cell surface: [[CD28]] (for autoregulation and intercellular association) and [[CTLA-4]] (for attenuation of regulation and cellular disassociation). CD86 works in tandem with [[CD80]] to prime T cells. |
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The ''CD86'' [[gene]] encodes a type I membrane protein that is a member of the [[immunoglobulin]] superfamily.<ref name="pmid7513726">{{cite journal | author = Chen C, Gault A, Shen L, Nabavi N | title = Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule | journal = J. Immunol. | volume = 152 | issue = 10 | pages = 4929–36 | year = 1994 | month = May | pmid = 7513726 | doi = | url = | issn = }}</ref> [[Alternative splicing]] results in two transcript variants encoding different [[protein isoform|isoform]]s. Additional transcript variants have been described, but their full-length sequences have not been determined.<ref>{{cite web | title = Entrez Gene: CD86 CD86 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=942| accessdate = }}</ref> |
The ''CD86'' [[gene]] encodes a type I membrane protein that is a member of the [[immunoglobulin]] superfamily.<ref name="pmid7513726">{{cite journal | author = Chen C, Gault A, Shen L, Nabavi N | title = Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule | journal = J. Immunol. | volume = 152 | issue = 10 | pages = 4929–36 | year = 1994 | month = May | pmid = 7513726 | doi = | url = | issn = }}</ref> [[Alternative splicing]] results in two transcript variants encoding different [[protein isoform|isoform]]s. Additional transcript variants have been described, but their full-length sequences have not been determined.<ref>{{cite web | title = Entrez Gene: CD86 CD86 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=942| accessdate = }}</ref> |
Revision as of 23:25, 14 February 2012
Template:PBB Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells.
The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily.[1] Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.[2]
Clinical significance
CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy.[3]
See also
References
- ^ Chen C, Gault A, Shen L, Nabavi N (1994). "Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule". J. Immunol. 152 (10): 4929–36. PMID 7513726.
{{cite journal}}
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ignored (help)CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: CD86 CD86 molecule".
- ^ Steidl C, Lee T, Shah SP, Farinha P, Han G, Nayar T, Delaney A, Jones SJ, Iqbal J, Weisenburger DD, Bast MA, Rosenwald A, Muller-Hermelink HK, Rimsza LM, Campo E, Delabie J, Braziel RM, Cook JR, Tubbs RR, Jaffe ES, Lenz G, Connors JM, Staudt LM, Chan WC, Gascoyne RD (2010). "Tumor-associated macrophages and survival in classic Hodgkin's lymphoma". N. Engl. J. Med. 362 (10): 875–85. doi:10.1056/NEJMoa0905680. PMC 2897174. PMID 20220182.
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Further reading
- Davila S, Froeling FE, Tan A; et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
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(help)CS1 maint: multiple names: authors list (link) - Csillag A, Boldogh I, Pazmandi K; et al. (2010). "Pollen-induced oxidative stress influences both innate and adaptive immune responses via altering dendritic cell functions". J. Immunol. 184 (5): 2377–85. doi:10.4049/jimmunol.0803938. PMC 3028537. PMID 20118277.
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(help)CS1 maint: multiple names: authors list (link) - Bossé Y, Lemire M, Poon AH; et al. (2009). "Asthma and genes encoding components of the vitamin D pathway". Respir. Res. 10: 98. doi:10.1186/1465-9921-10-98. PMC 2779188. PMID 19852851.
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(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Mosbruger TL, Duggal P, Goedert JJ; et al. (2010). "Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus". J. Infect. Dis. 201 (9): 1371–80. doi:10.1086/651606. PMC 2853721. PMID 20331378.
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(help)CS1 maint: multiple names: authors list (link) - Bugeon L, Dallman MJ (2000). "Costimulation of T cells". Am. J. Respir. Crit. Care Med. 162 (4 Pt 2): S164–8. PMID 11029388.
- Pan XM, Gao LB, Liang WB; et al. (2010). "CD86 +1057 G/A polymorphism and the risk of colorectal cancer". DNA Cell Biol. 29 (7): 381–6. doi:10.1089/dna.2009.1003. PMID 20380573.
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(help)CS1 maint: multiple names: authors list (link) - Dalla-Costa R, Pincerati MR, Beltrame MH; et al. (2010). "Polymorphisms in the 2q33 and 3q21 chromosome regions including T-cell coreceptor and ligand genes may influence susceptibility to pemphigus foliaceus". Hum. Immunol. 71 (8): 809–17. doi:10.1016/j.humimm.2010.04.001. PMID 20433886.
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(help)CS1 maint: multiple names: authors list (link) - Talmud PJ, Drenos F, Shah S; et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
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(help)CS1 maint: multiple names: authors list (link) - Carreño LJ, Pacheco R, Gutierrez MA; et al. (2009). "Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fc gamma receptors and costimulatory molecules on dendritic cells". Immunology. 128 (3): 334–41. doi:10.1111/j.1365-2567.2009.03138.x. PMC 2770681. PMID 20067533.
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(help)CS1 maint: multiple names: authors list (link) - Koyasu S (2003). "The role of PI3K in immune cells". Nat. Immunol. 4 (4): 313–9. doi:10.1038/ni0403-313. PMID 12660731.
- Kim SH, Lee JE, Kim SH; et al. (2009). "Allelic variants of CD40 and CD40L genes interact to promote antibiotic-induced cutaneous allergic reactions". Clin. Exp. Allergy. 39 (12): 1852–6. doi:10.1111/j.1365-2222.2009.03336.x. PMID 19735272.
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(help)CS1 maint: multiple names: authors list (link) - Liu Y, Liang WB, Gao LB; et al. (2010). "CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease". Hum. Immunol. 71 (11): 1141–6. doi:10.1016/j.humimm.2010.08.007. PMID 20732370.
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(help)CS1 maint: multiple names: authors list (link) - Ma XN, Wang X, Yan YY; et al. (2010). "Absence of association between CD86 +1057G/A polymorphism and coronary artery disease". DNA Cell Biol. 29 (6): 325–8. doi:10.1089/dna.2009.0987. PMID 20230296.
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(help)CS1 maint: multiple names: authors list (link) - Ishizaki Y, Yukaya N, Kusuhara K; et al. (2010). "PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis". Human genetics. 127 (4): HASH(0x31b6c40). doi:10.1007/s00439-009-0781-z. PMID 20066438.
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(help)CS1 maint: multiple names: authors list (link) - Chang TT, Kuchroo VK, Sharpe AH (2002). "Role of the B7-CD28/CTLA-4 pathway in autoimmune disease". Curr. Dir. Autoimmun. 5: 113–30. doi:10.1159/000060550. PMID 11826754.
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: CS1 maint: multiple names: authors list (link) - Grujic M, Bartholdy C, Remy M; et al. (2010). "The role of CD80/CD86 in generation and maintenance of functional virus-specific CD8+ T cells in mice infected with lymphocytic choriomeningitis virus". J. Immunol. 185 (3): 1730–43. doi:10.4049/jimmunol.0903894. PMID 20601595.
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(help)CS1 maint: multiple names: authors list (link) - Quaranta MG, Mattioli B, Giordani L, Viora M (2006). "The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS". FASEB J. 20 (13): 2198–208. doi:10.1096/fj.06-6260rev. PMID 17077296.
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: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Schuurhof A, Bont L, Siezen CL; et al. (2010). "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls". Pediatr. Pulmonol. 45 (6): 608–13. doi:10.1002/ppul.21229. PMID 20503287.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.