CD72: Difference between revisions
m Replace magic links with templates per local RfC and MediaWiki RfC |
Add info about CD72 being inhibitory co-receptor of BCR |
||
| Line 18: | Line 18: | ||
| LocusSupplementaryData = |
| LocusSupplementaryData = |
||
}} |
}} |
||
'''CD72''' ('''C'''luster of '''D'''ifferentiation '''72'''), also known in [[murine]] biology as '''Lyb-2''', is a protein active in the [[immune system]] of animals. It consists of two identical halves, each of about 39-43 [[Dalton (unit)|kD]], and is a C-type [[lectin]]. Its primarily locus of expression is [[B-cells]], where it appears to mediate aspects of B-cell - [[T-cell]] interaction. It is a ligand for [[CD5 (protein)|CD5]].<ref>Abbas, A.K. and Andrew Licktman, 2003, ''Cellular and Molecular Immunology'', p.512. {{ISBN|0-7216-0008-5}}.</ref> |
'''CD72''' ('''C'''luster of '''D'''ifferentiation '''72'''), also known in [[murine]] biology as '''Lyb-2''', is a protein active in the [[immune system]] of animals. It consists of two identical halves, each of about 39-43 [[Dalton (unit)|kD]], and is a C-type [[lectin]]. Its primarily locus of expression is [[B-cells]] (from the pro-B through the mature B-cell stage), where it appears to mediate aspects of B-cell - [[T-cell]] interaction. It is a ligand for [[CD5 (protein)|CD5]].<ref>Abbas, A.K. and Andrew Licktman, 2003, ''Cellular and Molecular Immunology'', p.512. {{ISBN|0-7216-0008-5}}.</ref> |
||
CD72 is a regulatory protein on B lymphocytes. The cytoplasmic tail of CD72 contains two potential immunoreceptor tyrosine-based inhibitory motifs, one of which has been shown to recruit the tyrosine phosphatase SHP- 1. These features suggest a negative regulatory role for CD72. CD72 is a nonredundant regulator of B-cell development and a negative regulator of B-cell responsiveness.<ref>{{Cite journal|date=2000-08|title=CD72, a negative regulator of B-cell responsiveness|url=http://dx.doi.org/10.1034/j.1600-065x.2000.00608.x|journal=Immunological Reviews|volume=176|issue=1|pages=75–85|doi=10.1034/j.1600-065x.2000.00608.x|issn=0105-2896}}</ref> |
|||
==See also== |
==See also== |
||
Revision as of 15:32, 7 November 2018
| CD72 molecule | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CD72 | ||||||
| NCBI gene | 971 | ||||||
| HGNC | 1696 | ||||||
| OMIM | 107272 | ||||||
| RefSeq | NM_001782 | ||||||
| UniProt | P21854 | ||||||
| Other data | |||||||
| Locus | Chr. 9 p | ||||||
| |||||||
CD72 (Cluster of Differentiation 72), also known in murine biology as Lyb-2, is a protein active in the immune system of animals. It consists of two identical halves, each of about 39-43 kD, and is a C-type lectin. Its primarily locus of expression is B-cells (from the pro-B through the mature B-cell stage), where it appears to mediate aspects of B-cell - T-cell interaction. It is a ligand for CD5.[1]
CD72 is a regulatory protein on B lymphocytes. The cytoplasmic tail of CD72 contains two potential immunoreceptor tyrosine-based inhibitory motifs, one of which has been shown to recruit the tyrosine phosphatase SHP- 1. These features suggest a negative regulatory role for CD72. CD72 is a nonredundant regulator of B-cell development and a negative regulator of B-cell responsiveness.[2]
See also
References
- ^ Abbas, A.K. and Andrew Licktman, 2003, Cellular and Molecular Immunology, p.512. ISBN 0-7216-0008-5.
- ^ "CD72, a negative regulator of B-cell responsiveness". Immunological Reviews. 176 (1): 75–85. 2000-08. doi:10.1034/j.1600-065x.2000.00608.x. ISSN 0105-2896.
{{cite journal}}: Check date values in:|date=(help)
External links
 | This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it. |