SIRPB1

SIRPB1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2D9C, 2JJU,%%s2JJV
Identifiers
Aliases	SIRPB1, CD172b, SIRP-BETA-1, signal regulatory protein beta 1
External IDs	OMIM: 603889; MGI: 3779828; HomoloGene: 82993; GeneCards: SIRPB1; OMA:SIRPB1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20p13 Start 1,561,385 bp End 1,620,061 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 A1|3 Start 15,560,811 bp End 15,640,125 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood right lung spleen bone marrow bone marrow cells appendix gallbladder lymph node Top expressed in granulocyte spermatid secondary oocyte primary oocyte bone marrow zygote spleen lung jejunum liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane secretory granule membrane cell surface Biological process cell surface receptor signaling pathway innate immune response signal transduction neutrophil degranulation positive regulation of cell-cell adhesion positive regulation of phagocytosis positive regulation of T cell activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10326 668101 Ensembl ENSG00000101307 ENSMUSG00000095028 UniProt O00241 Q5TFQ8 n/a RefSeq (mRNA) NM_001083910 NM_001135844 NM_006065 NM_001329157 NM_001330639 NM_001173460 RefSeq (protein) NP_001077379 NP_001129316 NP_001316086 NP_001317568 NP_006056 NP_001129316.1 n/a Location (UCSC) Chr 20: 1.56 – 1.62 Mb Chr 3: 15.56 – 15.64 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene. SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B).

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.

Interactions

SIRPB1 has been shown to interact with TYROBP.

Further reading

• Dietrich J, Cella M, Seiffert M, et al. (2000). "Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells". J. Immunol. 164 (1): 9–12. doi:10.4049/jimmunol.164.1.9. PMID 10604985.
• Tomasello E, Cant C, Bühring HJ, et al. (2000). "Association of signal-regulatory proteins beta with KARAP/DAP-12". Eur. J. Immunol. 30 (8): 2147–56. doi:10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1. PMID 10940905.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Cannon JP; Haire RN; Litman GW (2002). "Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate". Nat. Immunol. 3 (12): 1200–7. doi:10.1038/ni849. PMID 12415263. S2CID 19367972.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Liu Y, Soto I, Tong Q, et al. (2006). "SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration". J. Biol. Chem. 280 (43): 36132–40. doi:10.1074/jbc.M506419200. PMID 16081415.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Laplana M, Royo JL, Aluja A, López R, Heine-Sunyer H, Fibla J (September 2014). "SIRPB1 copy‐number polymorphism as candidate quantitative trait locus for impulsive‐disinhibited personality". Genes, Brains and Behavior. 13 (7): 653–62. doi:10.1111/gbb.12154. PMID 25039969.

External links

• SIRPB1 human gene location in the UCSC Genome Browser.
• SIRPB1 human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.