CEACAM3

CEACAM3
Identifiers
Aliases	CEACAM3, CD66D, CEA, CGM1, W264, W282, carcinoembryonic antigen related cell adhesion molecule 3, CEA cell adhesion molecule 3
External IDs	OMIM: 609142; HomoloGene: 130497; GeneCards: CEACAM3; OMA:CEACAM3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	41,811,554 bp
RNA expression pattern
	Top expressed in
	blood; ; granulocyte; ; bone marrow; ; bone marrow cells; ; periodontal fiber; ; monocyte; ; spleen; ; mucosa of transverse colon; ; trabecular bone; ; cecum;
	n/a
	More reference expression data
	; ;
	More reference expression data
Orthologs
	1084
	n/a
	ENSG00000170956
	n/a
	P40198
	n/a
	NM_001277163; NM_001815
	n/a
	NP_001264092; NP_001806
	n/a
	Wikidata
View/Edit Human

Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) also known as CD66d (Cluster of Differentiation 66d), is a member of the carcinoembryonic antigen (CEA) gene family..^[3]

This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.^[3]

Use

CEACAM3 is expressed exclusively on granulocytes and used as granulocyte marker.^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170956 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3".
^ CEACAM3: an innate immune receptor directed against human-restricted bacterial pathogens. Pils S, Gerrard DT, Meyer A, Hauck CR. Int J Med Microbiol. 2008 Oct;298(7-8):553-60.

Khan WN, Frängsmyr L, Teglund S, et al. (1992). "Identification of three new genes and estimation of the size of the carcinoembryonic antigen family". Genomics. 14 (2): 384–90. doi:10.1016/S0888-7543(05)80230-7. PMID 1427854.
Kuroki M, Arakawa F, Matsuo Y, et al. (1991). "Molecular cloning of nonspecific cross-reacting antigens in human granulocytes". J. Biol. Chem. 266 (18): 11810–7. PMID 2050678.
Thompson JA, Mauch EM, Chen FS, et al. (1989). "Analysis of the size of the carcinoembryonic antigen (CEA) gene family: isolation and sequencing of N-terminal domain exons". Biochem. Biophys. Res. Commun. 158 (3): 996–1004. CiteSeerX 10.1.1.657.2780. doi:10.1016/0006-291X(89)92821-0. PMID 2537643.
Watt SM, Fawcett J, Murdoch SJ, et al. (1994). "CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant". Blood. 84 (1): 200–10. doi:10.1182/blood.V84.1.200.200. PMID 8018919.
Nagel G, Grunert F, Kuijpers TW, et al. (1993). "Genomic organization, splice variants and expression of CGM1, a CD66-related member of the carcinoembryonic antigen gene family". Eur. J. Biochem. 214 (1): 27–35. doi:10.1111/j.1432-1033.1993.tb17892.x. PMID 8508798.
Skubitz KM, Campbell KD, Skubitz AP (1996). "CD66a, CD66b, CD66c, and CD66d each independently stimulate neutrophils". J. Leukoc. Biol. 60 (1): 106–17. doi:10.1002/jlb.60.1.106. PMID 8699114. S2CID 46292936.
Streichert T, Ebrahimnejad A, Ganzer S, et al. (2001). "The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes". Biochem. Biophys. Res. Commun. 289 (1): 191–7. doi:10.1006/bbrc.2001.5955. PMID 11708798.
Skubitz KM, Campbell KD, Skubitz AP (2002). "Synthetic peptides from the N-domains of CEACAMs activate neutrophils". J. Pept. Res. 58 (6): 515–26. doi:10.1034/j.1399-3011.2001.00931.x. PMC 7162001. PMID 12005421.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Booth JW, Telio D, Liao EH, et al. (2003). "Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae". J. Biol. Chem. 278 (16): 14037–45. doi:10.1074/jbc.M211879200. PMID 12571236.
McCaw SE, Schneider J, Liao EH, et al. (2003). "Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor". Mol. Microbiol. 49 (3): 623–37. doi:10.1046/j.1365-2958.2003.03591.x. PMID 12864848. S2CID 12071872.
Schmitter T, Agerer F, Peterson L, et al. (2004). "Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens". J. Exp. Med. 199 (1): 35–46. doi:10.1084/jem.20030204. PMC 1887732. PMID 14707113.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gimbergues P, Dauplat MM, Cayre A, et al. (2007). "Correlation between molecular metastases in sentinel lymph nodes of breast cancer patients and St Gallen risk category". Eur J Surg Oncol. 33 (1): 16–22. doi:10.1016/j.ejso.2006.09.013. PMID 17071045.
Gasser M, Gerstlauer C, Grimm M, et al. (2007). "Comparative analysis of predictive biomarkers for therapeutical strategies in colorectal cancer". Ann. Surg. Oncol. 14 (4): 1272–84. doi:10.1245/s10434-006-9155-0. PMID 17211733. S2CID 19408520.
Howell NR, Zheng W, Cheng L, et al. (2007). "Carcinomas of ovary and lung with clear cell features: can immunohistochemistry help in differential diagnosis?". Int. J. Gynecol. Pathol. 26 (2): 134–40. doi:10.1097/01.pgp.0000233166.56385.d0. PMID 17413979. S2CID 534457.
Stern-Ginossar N, Nedvetzki S, Markel G, et al. (2007). "Intercellular transfer of carcinoembryonic antigen from tumor cells to NK cells". J. Immunol. 179 (7): 4424–34. doi:10.4049/jimmunol.179.7.4424. PMID 17878338.

External links

CEACAM3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CEACAM3 genome location and CEACAM3 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170956 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3".

[4] CEACAM3: an innate immune receptor directed against human-restricted bacterial pathogens. Pils S, Gerrard DT, Meyer A, Hauck CR. Int J Med Microbiol. 2008 Oct;298(7-8):553-60.

[1]

[2]

[3]

[4]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

CEACAM3

Use

See also

References

Further reading

External links