FCGR2B

FCGR2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FCB, 3WJJ,%%s3WJL
Identifiers
Aliases	FCGR2B, CD32, CD32B, FCG2, FCGR2, IGFR2, Fc fragment of IgG receptor IIb, FcRII-c, FCGR2C
External IDs	OMIM: 604590; MGI: 95499; HomoloGene: 2974; GeneCards: FCGR2B; OMA:FCGR2B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	161,678,654 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	170,804,116 bp
RNA expression pattern
	Top expressed in
	placenta; ; right coronary artery; ; blood; ; spleen; ; monocyte; ; lymph node; ; synovial membrane; ; synovial joint; ; granulocyte; ; appendix;
	Top expressed in
	stroma of bone marrow; ; tibiofemoral joint; ; calvaria; ; granulocyte; ; skin of abdomen; ; blood; ; spleen; ; right kidney; ; molar; ; motor neuron;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; IgG binding; amyloid-beta binding; low-affinity IgG receptor activity; protein-containing complex binding; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane; external side of plasma membrane; dendritic spine; cell body; cytoplasm;
Biological process	viral process; immune response; signal transduction; regulation of immune response; negative regulation of type I hypersensitivity; negative regulation of antibody-dependent cellular cytotoxicity; follicular dendritic cell activation; mature B cell differentiation involved in immune response; follicular B cell differentiation; immune complex clearance by monocytes and macrophages; negative regulation of dendritic cell antigen processing and presentation; regulation of B cell antigen processing and presentation; negative regulation of immunoglobulin production; regulation of adaptive immune response; negative regulation of acute inflammatory response to antigenic stimulus; positive regulation of humoral immune response; negative regulation of humoral immune response mediated by circulating immunoglobulin; receptor-mediated endocytosis; phagocytosis, engulfment; defense response; inflammatory response; response to bacterium; regulation of signaling receptor activity; immunoglobulin mediated immune response; antigen processing and presentation of exogenous peptide antigen via MHC class II; cerebellum development; negative regulation of B cell proliferation; negative regulation of interleukin-10 production; Fc-gamma receptor signaling pathway involved in phagocytosis; negative regulation of macrophage activation; negative regulation of cytotoxic T cell degranulation; regulation of innate immune response; mast cell activation; positive regulation of JNK cascade; negative regulation of phagocytosis; positive regulation of phagocytosis; negative regulation of immune response; negative regulation of B cell receptor signaling pathway; negative regulation of B cell activation; cellular response to molecule of bacterial origin; regulation of immune complex clearance by monocytes and macrophages; positive regulation of neuron death; negative regulation of neutrophil activation; regulation of dendritic spine maintenance; cellular response to amyloid-beta; positive regulation of response to endoplasmic reticulum stress; negative regulation of dendritic cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	2213
	14130
	ENSG00000072694
	ENSMUSG00000026656
	P31994; P31995
	P08101
	NM_001002273; NM_001002274; NM_001002275; NM_001190828; NM_004001
	NM_001077189; NM_010187
NP_001002273; NP_001002274; NP_001002275; NP_001177757; NP_003992;
	NP_963857
	NP_001070657; NP_034317
	Wikidata
View/Edit Human	View/Edit Mouse

Low affinity immunoglobulin gamma Fc region receptor II-b is a protein that, in humans, is encoded by the FCGR2B gene. FCGR2B (CD32B) is a "low affinity" receptor for Immunoglobulin G (IgG). Mutation in the gene in humans leads to a lupus phenotype.^[5]^[6] The cytoplasmic part of this receptor contains an immunoreceptor tyrosine-based inhibitory motif, in contrast to the activating isoform, FCGR2A (CD32A).

Template:PBB Summary

Function

The inhibitory CD32B is expressed on B cells and myeloid dendritic cells.^[7] Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000072694 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026656 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (Jun 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science. 248 (4956): 732–5. doi:10.1126/science.2139735. PMID 2139735.
^ "Entrez Gene: FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)".
^ Boruchov AM, Heller G, Veri MC, Bonvini E, Ravetch JV, Young JW (2005). "Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions". J Clin Invest. 115 (10): 2914–23. doi:10.1172/JCI24772. PMC 1201664. PMID 16167082. (Free full text)
^ Rankin CT, Veri MC, Gorlatov S, Tuaillon N, Burke S, Huang L, Inzunza HD, Li H, Thomas S, Johnson S, Stavenhagen J, Koenig S, Bonvini E (2006). "CD32B, the human inhibitory Fc-γ receptor IIB, as a target for monoclonal antibody therapy of B-cell lymphoma". Blood. 108 (7): 2384–91. doi:10.1182/blood-2006-05-020602. PMID 16757681. (Free full text)
^ Zhou P, Comenzo RL, Olshen AB, Bonvini E, Koenig S, Maslak PG, Fleisher M, Hoffman J, Jhanwar S, Young JW, Nimer SD, Boruchov AM (2008). "CD32B is highly expressed on clonal plasma cells from patients with systemic light-chain amyloidosis and provides a target for monoclonal antibody–based therapy". Blood. 111 (7): 3403–6. doi:10.1182/blood-2007-11-125526. PMC 2275009. PMID 18216299. (Free full text)

External links

FCGR2B+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Template:PBB Controls

This immunology article is a stub. You can help Wikipedia by expanding it.

This protein-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000072694 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026656 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2139735-5] Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (Jun 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science. 248 (4956): 732–5. doi:10.1126/science.2139735. PMID 2139735.

[entrez-6] "Entrez Gene: FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)".

[7] Boruchov AM, Heller G, Veri MC, Bonvini E, Ravetch JV, Young JW (2005). "Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions". J Clin Invest. 115 (10): 2914–23. doi:10.1172/JCI24772. PMC 1201664. PMID 16167082. (Free full text)

[8] Rankin CT, Veri MC, Gorlatov S, Tuaillon N, Burke S, Huang L, Inzunza HD, Li H, Thomas S, Johnson S, Stavenhagen J, Koenig S, Bonvini E (2006). "CD32B, the human inhibitory Fc-γ receptor IIB, as a target for monoclonal antibody therapy of B-cell lymphoma". Blood. 108 (7): 2384–91. doi:10.1182/blood-2006-05-020602. PMID 16757681. (Free full text)

[9] Zhou P, Comenzo RL, Olshen AB, Bonvini E, Koenig S, Maslak PG, Fleisher M, Hoffman J, Jhanwar S, Young JW, Nimer SD, Boruchov AM (2008). "CD32B is highly expressed on clonal plasma cells from patients with systemic light-chain amyloidosis and provides a target for monoclonal antibody–based therapy". Blood. 111 (7): 3403–6. doi:10.1182/blood-2007-11-125526. PMC 2275009. PMID 18216299. (Free full text)

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

FCGR2B

Function

See also

References

Further reading

External links