Dimenhydrinate: Difference between revisions
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Dimenhydrinate is used as a [[deliriant]] at doses of 1200 to 2000 mg, although body weight plays a significant part in dosing of this drug. Slang terms for Dramamine used this way include "dime," "dime tabs," "D-Q," "substance D," "d-house," and "drams." Tripping on Dramamine is sometimes referred to as Dramatizing or "going a dime a dozen," a reference to the amount of Dramamine tabs generally necessary for a trip. The {{LD50}} (the dose at which 50% of animals tested produced fatal symptoms) for dimenhydrinate is 500 mg/kg in lab rats, |
Dimenhydrinate is used as a [[deliriant]] at doses of 1200 to 2000 mg, although body weight plays a significant part in dosing of this drug. Slang terms for Dramamine used this way include "dime," "dime tabs," "D-Q," "substance D," "d-house," and "drams." Tripping on Dramamine is sometimes referred to as Dramatizing or "going a dime a dozen," a reference to the amount of Dramamine tabs generally necessary for a trip. The {{LD50}} (the dose at which 50% of animals tested produced fatal symptoms) for dimenhydrinate is 500 mg/kg in lab rats, though there is no laboratory evidence of weight correlation so the same dose may likewise be fatal in 50 percent of humans. |
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Many users report a side effect profile consistent with [[tropane]] glycoalkaloidal (e.g. [[atropine]]) poisoning as both show antagonism of [[muscarinic acetylcholine receptors]] in both the central and autonomic nervous system, which inhibits various signal transduction pathways. In the CNS, dimenhydrinate readily crosses the [[blood-brain barrier]], exerting effects within the visual and auditory cortex. |
Many users report a side effect profile consistent with [[tropane]] glycoalkaloidal (e.g. [[atropine]]) poisoning as both show antagonism of [[muscarinic acetylcholine receptors]] in both the central and autonomic nervous system, which inhibits various signal transduction pathways. In the CNS, dimenhydrinate readily crosses the [[blood-brain barrier]], exerting effects within the visual and auditory cortex. |
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Revision as of 20:29, 28 June 2014
 | This article needs additional citations for verification. (June 2012) |
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| Combination of | |
|---|---|
| diphenhydramine | antihistamine |
| 8-chlorotheophylline | stimulant |
| Clinical data | |
| Trade names | Dramamine |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a607046 |
| Pregnancy category |
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| Routes of administration | Oral, Rectal, I.V. |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
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| PubChem CID | |
| DrugBank | |
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| KEGG | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.007.593 |
| Chemical and physical data | |
| 3D model (JSmol) | |
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  (what is this?) (verify) | |
Dimenhydrinate is an over-the-counter drug used to prevent nausea and motion sickness. It is most commonly prepared as tablets, although it is also available in liquid form and in suppositories. Dimenhydrinate is a combination of two drugs: diphenhydramine and 8-chlorotheophylline, a chlorinated derivative of theophylline.
Medical uses
Dimenhydrinate is primarily used for nausea and vomiting.
Diphenhydramine is the primary constituent of dimenhydrinate and dictates the primary effect. The main difference relative to pure diphenhydramine is a lower potency due to being combined with 8-chlorotheophylline. 50 mg of dimenhydrinate contains 27.2 mg of diphenhydramine.
8-Chlorotheophylline was added in order to counteract drowsiness. Theophylline is very closely related to caffeine and theobromine, mild central nervous system stimulants. It was thought by scientists that by combining the antiemetic effects of diphenhydramine with a stimulant, the extreme drowsiness induced by the former could be mitigated somewhat by the latter. The sedation caused by diphenhydramine, however, is substantially stronger than the stimulation caused by 8-chlorotheophylline, so the overall effect is still mostly sedating.
Recreational use
 | This section possibly contains original research. (May 2013) |
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Dimenhydrinate is used as a deliriant at doses of 1200 to 2000 mg, although body weight plays a significant part in dosing of this drug. Slang terms for Dramamine used this way include "dime," "dime tabs," "D-Q," "substance D," "d-house," and "drams." Tripping on Dramamine is sometimes referred to as Dramatizing or "going a dime a dozen," a reference to the amount of Dramamine tabs generally necessary for a trip. The LD50 (the dose at which 50% of animals tested produced fatal symptoms) for dimenhydrinate is 500 mg/kg in lab rats, though there is no laboratory evidence of weight correlation so the same dose may likewise be fatal in 50 percent of humans.
Many users report a side effect profile consistent with tropane glycoalkaloidal (e.g. atropine) poisoning as both show antagonism of muscarinic acetylcholine receptors in both the central and autonomic nervous system, which inhibits various signal transduction pathways. In the CNS, dimenhydrinate readily crosses the blood-brain barrier, exerting effects within the visual and auditory cortex.
Other CNS effects occur within the limbic system and hippocampus, causing confusion and temporary amnesia due to decreased acetylcholine signaling. Toxicology also manifests in the autonomic nervous system, primarily at the neuromuscular junction, resulting in ataxia and extrapyramidal side-effects and the feeling of heaviness in the legs, and at sympathetic post-ganglionic junctions, causing urinary retention, pupil dilation, tachycardia, irregular urination, and dry red skin caused by decreased exocrine gland secretions, and mucous membranes. Considerable overdosage can lead to myocardial infarction (heart attack), serious ventricular dysrhythmias, coma and death. Such a side-effect profile is thought to give ethanolamine-class antihistamines a relatively low abuse liability. The specific antidote for dimenhydrinate poisoning is physostigmine, usually given by IV in a hospital.
Veterinary use
Dimenhydrinate has successfully been used as an antiemetic and sedative in housepets. It is commonly used to reduce the effects of idiopathic vestibular syndrome. The suggested dosage is 50 mg for dogs[1] and 10 mg for cats; duration of effect is 8 hours.
This dosage though is not a proper measure for all pets and should be adjusted by weight.
Brand names
In United States, it is marketed under brand names Dramamine, Driminate, Gravol, Gravamin, Vomex, and Vertirosan. It is marketed in Brazil as Dramin, in Canada as Gravol, in Ecuador as Anautin, in Hungary as Daedalon, in Sweden as Amosyt, in Indonesia as Antimo, in Italy as Xamamina, in Peru as Gravicoll, in Poland as Aviomarin,[2] in Portugal as Viabom, in Serbia as Dimigal, in Spain as Biodramina, and in Thailand as ไดเมนนีน (Daimenin).
References