ICOSLG

ICOSLG
Identifiers
Aliases	ICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS, inducible T-cell co-stimulator ligand, inducible T-cell costimulator ligand, inducible T cell costimulator ligand, B7h
External IDs	OMIM: 605717; MGI: 1354701; HomoloGene: 49412; GeneCards: ICOSLG; OMA:ICOSLG - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	44,240,966 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	77,919,747 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; putamen; ; bone marrow cells; ; substantia nigra; ; skin of limb; ; skin of abdomen; ; prefrontal cortex; ; amygdala; ; lymph node; ; hippocampus proper;
	Top expressed in
	spleen; ; secondary oocyte; ; cumulus cell; ; blood; ; subcutaneous adipose tissue; ; submandibular gland; ; lip; ; aortic valve; ; pyloric antrum; ; gastric mucosa;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; protein binding; identical protein binding;
Cellular component	integral component of membrane; extracellular exosome; membrane; plasma membrane; external side of plasma membrane; cytoplasmic ribonucleoprotein granule;
Biological process	B cell activation; defense response; T cell costimulation; adaptive immune response; hyperosmotic response; T cell activation; signal transduction; positive regulation of activated T cell proliferation; immune system process; regulation of immune response; T cell receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23308
	50723
	ENSG00000160223
	ENSMUSG00000000732
	O75144
	Q9JHJ8
NM_001283050; NM_001283051; NM_001283052; NM_015259; NM_001365759;
	NM_001395918
	NM_015790
	NP_001269979; NP_001269980; NP_001269981; NP_056074; NP_001352688
	NP_056605
	Wikidata
View/Edit Human	View/Edit Mouse

ICOS ligand is a protein that in humans is encoded by the ICOSLG gene.^[5]^[6]^[7] ICOSLG has also been designated as CD275 (cluster of differentiation 275).

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160223 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000732 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
^ Yoshinaga SK, Zhang M, Pistillo J, Horan T, Khare SD, Miner K, Sonnenberg M, Boone T, Brankow D, Dai T, Delaney J, Han H, Hui A, Kohno T, Manoukian R, Whoriskey JS, Coccia MA (October 2000). "Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS". International Immunology. 12 (10): 1439–47. doi:10.1093/intimm/12.10.1439. PMID 11007762.
^ "Entrez Gene: ICOSLG inducible T-cell co-stimulator ligand".

Flesch IE (2003). "Inducible costimulator-ligand (ICOS-L)". Journal of Biological Regulators and Homeostatic Agents. 16 (3): 217–9. PMID 12456022.
Ling V, Wu PW, Finnerty HF, Bean KM, Spaulding V, Fouser LA, Leonard JP, Hunter SE, Zollner R, Thomas JL, Miyashiro JS, Jacobs KA, Collins M (February 2000). "Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor". Journal of Immunology. 164 (4): 1653–7. doi:10.4049/jimmunol.164.4.1653. PMID 10657606.
Aicher A, Hayden-Ledbetter M, Brady WA, Pezzutto A, Richter G, Magaletti D, Buckwalter S, Ledbetter JA, Clark EA (May 2000). "Characterization of human inducible costimulator ligand expression and function". Journal of Immunology. 164 (9): 4689–96. doi:10.4049/jimmunol.164.9.4689. PMID 10779774.
Wang S, Zhu G, Chapoval AI, Dong H, Tamada K, Ni J, Chen L (October 2000). "Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS". Blood. 96 (8): 2808–13. doi:10.1182/blood.V96.8.2808. PMID 11023515.
Ling V, Wu PW, Miyashiro JS, Marusic S, Finnerty HF, Collins M (June 2001). "Differential expression of inducible costimulator-ligand splice variants: lymphoid regulation of mouse GL50-B and human GL50 molecules". Journal of Immunology. 166 (12): 7300–8. doi:10.4049/jimmunol.166.12.7300. PMID 11390480.
Sperling AI, Bluestone JA (July 2001). "ICOS costimulation: It's not just for TH2 cells anymore". Nature Immunology. 2 (7): 573–4. doi:10.1038/89709. PMID 11429535. S2CID 31317654.
Wang S, Zhu G, Tamada K, Chen L, Bajorath J (April 2002). "Ligand binding sites of inducible costimulator and high avidity mutants with improved function". The Journal of Experimental Medicine. 195 (8): 1033–41. doi:10.1084/jem.20011607. PMC 2193694. PMID 11956294.
Khayyamian S, Hutloff A, Büchner K, Gräfe M, Henn V, Kroczek RA, Mages HW (April 2002). "ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cells". Proceedings of the National Academy of Sciences of the United States of America. 99 (9): 6198–203. Bibcode:2002PNAS...99.6198K. doi:10.1073/pnas.092576699. PMC 122926. PMID 11983910.
Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang TT, Sharpe AH, Berry G, DeKruyff RH, Umetsu DT (September 2002). "Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity". Nature Medicine. 8 (9): 1024–32. doi:10.1038/nm745. PMID 12145647. S2CID 30454021.
Kurosawa S, Myers AC, Chen L, Wang S, Ni J, Plitt JR, Heller NM, Bochner BS, Schleimer RP (May 2003). "Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells". American Journal of Respiratory Cell and Molecular Biology. 28 (5): 563–73. doi:10.1165/rcmb.2002-0199OC. PMID 12707012.
Chen XL, Cao XD, Kang AJ, Wang KM, Su BS, Wang YL (June 2003). "In situ expression and significance of B7 costimulatory molecules within tissues of human gastric carcinoma". World Journal of Gastroenterology. 9 (6): 1370–3. doi:10.3748/wjg.v9.i6.1370. PMC 4611819. PMID 12800259.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Iwai H, Abe M, Hirose S, Tsushima F, Tezuka K, Akiba H, Yagita H, Okumura K, Kohsaka H, Miyasaka N, Azuma M (September 2003). "Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis". Journal of Immunology. 171 (6): 2848–54. doi:10.4049/jimmunol.171.6.2848. PMID 12960306.
Schreiner B, Wischhusen J, Mitsdoerffer M, Schneider D, Bornemann A, Melms A, Tolosa E, Weller M, Wiendl H (December 2003). "expression of the B7-related molecule ICOSL by human glioma cells in vitro and in vivo". Glia. 44 (3): 296–301. doi:10.1002/glia.10291. PMID 14603470. S2CID 25318238.
Saatian B, Yu XY, Yu X, Lane AP, Doyle T, Casolaro V, Spannhake EW (July 2004). "Expression of genes for B7-H3 and other T cell ligands by nasal epithelial cells during differentiation and activation". American Journal of Physiology. Lung Cellular and Molecular Physiology. 287 (1): L217-25. doi:10.1152/ajplung.00132.2003. PMID 15047568.
Nakazawa A, Dotan I, Brimnes J, Allez M, Shao L, Tsushima F, Azuma M, Mayer L (May 2004). "The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells". Gastroenterology. 126 (5): 1347–57. doi:10.1053/j.gastro.2004.02.004. PMID 15131796.

External links

ICOSLG+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160223 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000732 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9734811-5] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.

[pmid11007762-6] Yoshinaga SK, Zhang M, Pistillo J, Horan T, Khare SD, Miner K, Sonnenberg M, Boone T, Brankow D, Dai T, Delaney J, Han H, Hui A, Kohno T, Manoukian R, Whoriskey JS, Coccia MA (October 2000). "Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS". International Immunology. 12 (10): 1439–47. doi:10.1093/intimm/12.10.1439. PMID 11007762.

[entrez-7] "Entrez Gene: ICOSLG inducible T-cell co-stimulator ligand".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

References

Further reading

External links